Results 311 to 320 of about 813,774 (373)

Beyond Iron Deficiency: Unveiling the Prevalence of Folate and Vitamin B12 Deficiencies in Major Surgical Patients. [PDF]

Transfus Med Hemother
Kotlyar MJ, Meybohm P, Hof L, Koch M, Blum LV, Kloka JA, Mehic D, Neef V, Zacharowski K, Choorapoikayil S.   +9 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Extracellular vesicle-linked vitamin B12 acquisition via novel binding proteins in Bacteroides thetaiotaomicron. [PDF]

Biochem J
Juodeikis R, Ulrich R, Clarke C, Banasik M, Deery E, Saalbach G, Kräutler B, Carding SR, Geeves MA, Pickersgill RW, Warren MJ.   +10 more
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Multifaceted Clinical Spectrum of Vitamin B12 Deficiency - a Case Report and Literature Review. [PDF]

J Blood Med
Pustelnik E, Pikora K, Hartman MZ, Kurzeja M, Czuwara J, Łaguna P.   +5 more
europepmc   +1 more source

Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF‐21), and insulin‐like growth factor binding protein 2 (IGFBP‐2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Metabolic disorders are risk factors for Alzheimer's disease (AD), although underlying mechanisms remain unclear. We investigated the relationship between peripheral metabolic markers – adiponectin, fibroblast growth factor 21 (FGF‐21), and insulin‐like growth factor binding protein 2 (IGFBP‐2) – and AD.
Caroline Dallaire‐Théroux, Helena L. Denis, Rosalie Cottez, Cyntia Tremblay, Amélie Provencher, Josue Valentin‐Escalera, Manon Leclerc, Andreanne Loiselle, Marine Tournissac, Olivier Potvin, Sylvie Belleville, Anne Gangloff, Frederic Picard, Henrik Zetterberg, Consortium for the Early Identification of Alzheimer's Disease – Quebec (CIMA‐Q), Frédéric Calon   +15 more
wiley   +1 more source

Masked vitamin B12 deficiency in pernicious anaemia: A diagnostic trap due to assay interference-Case report. [PDF]

SAGE Open Med Case Rep
Abdulgayoom M, Abdelmahmuod E, Al-Mashdali AF, Abuazab YR, Amer A, Ganwo I, Mohamed S.   +6 more
europepmc   +1 more source

Overview: Existing Context and the Need to Generate Evidence of the Impact of Large‐Scale Food Fortification on the Prevalence of Anemia

Maternal &Child Nutrition, Volume 22, Issue 1, March 2026.
Manpreet Chadha, Daniel Lopez de Romana, Helena Pachón, Mandana Arabi   +3 more
wiley   +1 more source