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2022
Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
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Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
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2022
Photoreceptor proteins enable living organisms to sense light and transduce this signal into biochemical outputs to elicit appropriate cellular responses. Their light sensing is typically mediated by covalently or noncovalently bound molecules called chromophores, which absorb light of specific wavelengths and modulate protein structure and biological ...
S, Padmanabhan +4 more
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Photoreceptor proteins enable living organisms to sense light and transduce this signal into biochemical outputs to elicit appropriate cellular responses. Their light sensing is typically mediated by covalently or noncovalently bound molecules called chromophores, which absorb light of specific wavelengths and modulate protein structure and biological ...
S, Padmanabhan +4 more
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BMJ, 2014
#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes ...
Alesia, Hunt +2 more
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#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes ...
Alesia, Hunt +2 more
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Child and Adolescent Mental Health, 2020
BACKGROUND Depression is a heterogeneous disorder and is thought to develop as a result of complex interactions between genetic and environmental factors. One-carbon metabolism that includes vitamin B12, folic acid, and homocysteine has been investigated
E. Esnafoglu, Deniz Deniz Ozturan
semanticscholar +1 more source
BACKGROUND Depression is a heterogeneous disorder and is thought to develop as a result of complex interactions between genetic and environmental factors. One-carbon metabolism that includes vitamin B12, folic acid, and homocysteine has been investigated
E. Esnafoglu, Deniz Deniz Ozturan
semanticscholar +1 more source
2005
The uptake of vitamin B12 from the intestine into the circulation is perhaps the most complex uptake mechanism of all the vitamins, involving no less than five separate VB12-binding molecules, receptors and transporters. Each molecule involved in uptake has a separate affinity and specificity for VB12 as well as a separate cell receptor.
G J, Russell-Jones, D H, Alpers
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The uptake of vitamin B12 from the intestine into the circulation is perhaps the most complex uptake mechanism of all the vitamins, involving no less than five separate VB12-binding molecules, receptors and transporters. Each molecule involved in uptake has a separate affinity and specificity for VB12 as well as a separate cell receptor.
G J, Russell-Jones, D H, Alpers
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Journal of Diabetes, 2019
Metformin is first‐line therapy for patients with diabetes. However, it may lower vitamin B12 concentrations, which could have hematological or neurological implications. This meta‐analyses reviewed all available studies on associations between metformin
Wenjia Yang, X. Cai, Hai–ya Wu, L. Ji
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Metformin is first‐line therapy for patients with diabetes. However, it may lower vitamin B12 concentrations, which could have hematological or neurological implications. This meta‐analyses reviewed all available studies on associations between metformin
Wenjia Yang, X. Cai, Hai–ya Wu, L. Ji
semanticscholar +1 more source
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1993
Chemicals/CAS: cyanocobalamin, 53570-76-6, 68-19-9, 8064-09-3; methylmalonic acid, 516-05-2; Methylmalonic Acid, 516-05-2; Vitamin B 12, 68-19 ...
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Chemicals/CAS: cyanocobalamin, 53570-76-6, 68-19-9, 8064-09-3; methylmalonic acid, 516-05-2; Methylmalonic Acid, 516-05-2; Vitamin B 12, 68-19 ...
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Vitamin B12 and the B12 Coenzymes
1995Publisher Summary Scientific investigations of the biochemistry of the structure and the mode of action of vitamin B12 have cleared up many of the puzzles regarding its medical relevance to pernicious anemia. Structural studies have revealed a complicated molecule with many sterically constrained areas, honed for efficient use by an enzyme that needs
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Vitamin B12 absorption and malabsorption.
Vitamins and hormones, 2022J. Guéant +2 more
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1975
Vitamin B12 is the term applied to a group of chemically related metabolically equiactive compounds with a central ‘corrin’ ring system (porphyrin-like) surrounding a cobalt atom. The structure of the principle compounds with mammalian activity is shown in Figure 33. In natural form, vitamin B12 is probably bound to protein.
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Vitamin B12 is the term applied to a group of chemically related metabolically equiactive compounds with a central ‘corrin’ ring system (porphyrin-like) surrounding a cobalt atom. The structure of the principle compounds with mammalian activity is shown in Figure 33. In natural form, vitamin B12 is probably bound to protein.
openaire +1 more source