Results 341 to 350 of about 797,518 (380)
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BMJ, 2014
#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes ...
Susan Robinson +2 more
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#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes ...
Susan Robinson +2 more
openaire +3 more sources
2017
Vitamin B12 is the generic descriptor for all corrinoids (compounds containing the cobalt-centered corrin nucleus) exhibiting the biological activity of cyanocobalamin. Vitamin B12 is not found in fruits or vegetables; meat and fish are the best sources.
Gerald F. Combs, Jr., James P. McClung
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Vitamin B12 is the generic descriptor for all corrinoids (compounds containing the cobalt-centered corrin nucleus) exhibiting the biological activity of cyanocobalamin. Vitamin B12 is not found in fruits or vegetables; meat and fish are the best sources.
Gerald F. Combs, Jr., James P. McClung
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Journal of the American Pharmaceutical Association (Scientific ed.), 1956
Abstract The rate of destruction of crystalline vitamin Bu in neutral aqueous solutions, when exposed to direct sunlight, indirect sunlight, dim daylight, artificial light, ultraviolet light, and various monochromatic light sources has been determined.
Catherine Wilson, Leon J. Demerre
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Abstract The rate of destruction of crystalline vitamin Bu in neutral aqueous solutions, when exposed to direct sunlight, indirect sunlight, dim daylight, artificial light, ultraviolet light, and various monochromatic light sources has been determined.
Catherine Wilson, Leon J. Demerre
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Journal of Diabetes, 2019
Metformin is first‐line therapy for patients with diabetes. However, it may lower vitamin B12 concentrations, which could have hematological or neurological implications. This meta‐analyses reviewed all available studies on associations between metformin
Wenjia Yang, X. Cai, Hai–ya Wu, L. Ji
semanticscholar +1 more source
Metformin is first‐line therapy for patients with diabetes. However, it may lower vitamin B12 concentrations, which could have hematological or neurological implications. This meta‐analyses reviewed all available studies on associations between metformin
Wenjia Yang, X. Cai, Hai–ya Wu, L. Ji
semanticscholar +1 more source
Vitamin B12 and the B12 Coenzymes
1995Publisher Summary Scientific investigations of the biochemistry of the structure and the mode of action of vitamin B12 have cleared up many of the puzzles regarding its medical relevance to pernicious anemia. Structural studies have revealed a complicated molecule with many sterically constrained areas, honed for efficient use by an enzyme that needs
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1957
Publisher Summary Since the chemistry of the antipernicious anemia factor, vitamin B 12 , was last reviewed in “Vitamins and Hormones” by Folkers and Wolf, outstanding progress has been made, resulting in the complete structural elucidation of the vitamin.
Todd A, Johnson Aw
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Publisher Summary Since the chemistry of the antipernicious anemia factor, vitamin B 12 , was last reviewed in “Vitamins and Hormones” by Folkers and Wolf, outstanding progress has been made, resulting in the complete structural elucidation of the vitamin.
Todd A, Johnson Aw
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1954
Publisher Summary Soon after the epoch-making recognition of the effectiveness of whole liver therapy for the control of pernicious anemia, various groups of investigators carried out programs on the fractionation of liver extracts for the purification of the active principle.
Donald E. Wolf, Karl Folkers
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Publisher Summary Soon after the epoch-making recognition of the effectiveness of whole liver therapy for the control of pernicious anemia, various groups of investigators carried out programs on the fractionation of liver extracts for the purification of the active principle.
Donald E. Wolf, Karl Folkers
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2022
Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
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Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
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2005
The uptake of vitamin B12 from the intestine into the circulation is perhaps the most complex uptake mechanism of all the vitamins, involving no less than five separate VB12-binding molecules, receptors and transporters. Each molecule involved in uptake has a separate affinity and specificity for VB12 as well as a separate cell receptor.
Gregory J. Russell-Jones +1 more
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The uptake of vitamin B12 from the intestine into the circulation is perhaps the most complex uptake mechanism of all the vitamins, involving no less than five separate VB12-binding molecules, receptors and transporters. Each molecule involved in uptake has a separate affinity and specificity for VB12 as well as a separate cell receptor.
Gregory J. Russell-Jones +1 more
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Vitamin B12 absorption and malabsorption.
Vitamins and hormones, 2022J. Guéant +2 more
semanticscholar +1 more source