Arthritis &Rheumatology, EarlyView.Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley +1 more source
Vitamin B12 deficiency is endemic in Indian population: A perspective from North India
Indian Journal of Endocrinology and Metabolism, 2019 Background: Vitamin B12 deficiency is believed to be widespread in Indian population. However, more data is needed to fuel a meaningful debate on preventive and therapeutic strategies.
Rajiv Singla +5 more
doaj +1 more source
Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease. [PDF]
, 2019 ObjectiveIn Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability.
Christine, Chadwick W +3 more
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Asymmetric Dialysis: Truly Unified and Simultaneous Single‐Pass Concentration and Buffer Exchange
Biotechnology and Bioengineering, EarlyView.Asymmetric dialysis, a novel one‐step continuous process combining ultrafiltration and diafiltration, achieves high product concentrations (up to 200 g/L) with low pressures and reduces buffer consumption by 75% compared to conventional methods. This sustainable, low‐cost technology demonstrates significant potential for integration into continuous ...
Ujwal Patil +3 more
wiley +1 more source
Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]
, 2011 : Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE +4 more
core +4 more sources
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition [PDF]
, 2015 Although the prevalence of malnutrition in the old age is increasing worldwide a synthetic understanding of the impact of aging on the intake, digestion, and absorption of nutrients is still lacking.
Bordoni, Alessandra +11 more
core +4 more sources
Bioenhancer‐Driven Modulation of Membrane Dynamics Improves B‐Vitamin Uptake in Caco‐2 Cells
ChemFoodChem, EarlyView.Natural bioenhancers such as extracts from ginger, turmeric, black pepper, and spearmint increase the uptake of vitamins B1, B5, B6, and B7 in Caco‐2 cells. Micellized formulations further increase efficacy. These findings indicate that altered membrane fluidity contributes to enhanced cellular absorption, providing a new route to improve vitamin B ...
Verena Preinfalk +9 more
wiley +1 more source
Oxidative stress and DNA damage profile in cord blood of vitamin B12-deficient newborns [PDF]
Journal of Medical BiochemistryBackground: Vitamin B12 is an essential biomolecule involved in DNA synthesis, epigenetic regulation, and energy metabolism. Maternal vitamin B12 deficiency during pregnancy has been linked to oxidative stress and impaired DNA integrity. This study aimed
Kose Dogan, Demir Mahmut, Kirmit Adnan
doaj +1 more source
Vitamin B12 Intake To Megaloblastic Anemia On Vegetarian In Vihara Meitriya Khirti Palembang [PDF]
, 2018 Nowadays more and more people are consciously diverting their eating habits from main foods consisting of meat into meatless foods consisting of various types of vegetables, nuts, seeds, grains and fruits that do not contain vitamin B12.
Nugroho, M. R. (Muhammad) +1 more
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