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Vitamin B-12 and Perinatal Health. [PDF]
Adv Nutr, 2015 Vitamin B-12 deficiency (
Finkelstein JL, Layden AJ, Stover PJ.
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Vitamin B-12 and Cognition in Children. [PDF]
Adv Nutr, 2016 Vitamin B-12 is essential for brain development, neural myelination, and cognitive function. Inadequate vitamin B-12 status during pregnancy and early childhood has been associated with adverse child health outcomes, including impaired cognitive development. However, the underlying mechanisms have not been elucidated.
Venkatramanan S +3 more
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Vitamin B-12 and cognition in the elderly [PDF]
The American Journal of Clinical Nutrition, 2009 Vitamin B-12 deficiency is often associated with cognitive deficits. Here we review evidence that cognition in the elderly may also be adversely affected at concentrations of vitamin B-12 above the traditional cutoffs for deficiency. By using markers such as holotranscobalamin and methylmalonic acid, it has been found that cognition is associated with ...
Smith, A, Refsum, H
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Advances in Nutrition, 2010 Vitamin B-12 is a cofactor for 2 enzymes. In the cytoplasm, methionine synthase requires vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine to methionine by transfer of a methyl group from methyltetrahydrofolate. This enzyme links the methylation pathway through synthesis of the methyl donor S-adenosyl methionine ...
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Oral vitamin B12versus intramuscular vitamin B12for vitamin B12deficiency [PDF]
Cochrane Database of Systematic Reviews, 2018 Vitamin B12 deficiency is common, and the incidence increases with age. Most people with vitamin B12 deficiency are treated in primary care with intramuscular (IM) vitamin B12. Doctors may not be prescribing oral vitamin B12 formulations because they may be unaware of this option or have concerns regarding its effectiveness.To assess the effects of ...
Ling Ling Qin +5 more
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Cellular Import of Cobalamin (Vitamin B-12) [PDF]
The Journal of Nutrition, 1999 Recent studies have isolated and characterized human gastric intrinsic factor (IF) and transcobalamin II (TC II) genes, whose products mediate the import of cobalamin (Cbl; Vitamin B-12) across cellular plasma membranes. Analyses of cDNA and genomic clones of IF and TC II have provided some important insights into their sites of expression, structure ...
Bellur Seetharam, Ning Li, Santanu Bose
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The Journal of nutrition, health and aging, 2012 Vegetarians are more vascular-healthy but those with subnormal vitamin B-12 status have impaired arterial endothelial function and increased intima-media thickness. We aimed to study the impact of vitamin B-12 supplementation on these markers, in the vegetarians.Double-blind, placebo controlled, randomised crossover study.Community dwelling vegetarians.
Y. K. P. Poon +8 more
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Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status [PDF]
The American Journal of Clinical Nutrition, 2007 It has been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be used to assess absorption. To develop a reliable clinical absorption test that uses holo-TC, it is necessary to determine the optimal timeline for vitamin B-12 administration and postdose assessment.The objective of this study was to assess the ...
Gail P. A. Kauwell +8 more
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VITAMIN B 12 CAUSES AND TREATMENTS
, 2019 Introduction: In this article, seven questions answered about vitamin B12 deficiency. We will discusses the absorption of vitamin B12, the physiology, the importance and prevalence of the deficit, the way to recognize it early, and then we will talk about the several laboratory biomarkers to detect vitamin B12 deficiency, and the treatment.Dorothy ...
Nashmi Saloum Al ETesh +12 more
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