Results 161 to 170 of about 310,175 (350)

Vitamin B₁₂ deficiency in captive monkeys and its effect on the nervous system and the blood [PDF]

, 1970
Charles Oxnard, William Smith, Ildemaro Torres   +2 more
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Dietary Vitamin B₁₂ Deficiency [PDF]

British Journal of Psychiatry, 1984
F, Rawlinson, J M, Eagles
openaire   +2 more sources

High frequency of vitamin B₁₂ deficiency in a Brazilian population [PDF]

, 2010
JM Xavier, FF Costa, JM Annichino-Bizzacchi, STO Saad   +3 more
openalex   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

The transcobalamin receptor knockout mouse: a model for vitamin B ₁₂ deficiency in the central nervous system

, 2013
Shao‐Chiang Lai, Yasumi Nakayama, Jeffrey M. Sequeira, Bogdan J. Wlodarczyk, Robert M. Cabrera, Richard H. Finnell, Teodoro Bottiglieri, Edward V. Quadros   +7 more
openalex   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Comparison Of Vitamin B12 Level Among Vegetarian And Non Vegetarian Apparently Healthy Individuals In District Tharparkar

Journal of Bahria University Medical and Dental College, 2012
Objective: Subjects adopting a vegetarian diet are liable to vitamin B12 deficiency. The current work was undertaken to investigate vitamin B12 status in apparently healthy vegetarians in Mithi, district Tharparkar, Sindh.
Aneel Kapoor, Nudrat Anwar Zuberi, Muktiar Baig   +2 more
doaj  

Prevalence of iron and Vitamin B ₁₂ deficiencies and inflammatory anemia in treatment-naive patients with cancer: A cross-sectional study

, 2020
Avinash Pandey, Raj Aryan, Krishna Murari, Shivkant Singh, Piyush Pankaj   +4 more
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source