Results 171 to 180 of about 340,270 (377)

Cellular folate vitamer distribution during and after correction of vitamin B₁₂ deficiency: a case for the methylfolate trap [PDF]

, 2005
Yvo M. Smulders, Desirée E.C. Smith, Rob Kok, Tom Teerlink, Dorine W. Swinkels, Coen D.A. Stehouwer, C. Jakobs   +6 more
openalex   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, EarlyView.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

Evaluation of reticulocyte parameters in iron deficiency, vitamin B₁₂ deficiency and β‐thalassemia minor patients [PDF]

, 2007
Cengiz Ceylan, Mine Miskioğlu, Hülya Çolak, Bülent Kiliççioğlu, Emre Özdemir   +4 more
openalex   +1 more source

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

Advanced Science, EarlyView.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin, Yulong Hong, Yongqi Zhao, Wensheng Shi, Ruilin Liu, Xinyu You, Chong Yang, Yu Zhang   +7 more
wiley   +1 more source

Rumen Succinate Production May Ameliorate the Effects of Cobalt-Vitamin B-12 Deficiency on Methylmalonyl CoA Mutase in Sheep

, 1991
D. G. Kennedy, P. B. Young, W.J. McCaughey, S. Kennedy, W. John Blanchflower   +4 more
openalex   +1 more source

In vitamin B ₁₂ deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations [PDF]

, 2007
Jacob Selhub, Martha Savaria Morris, Paul F. Jacques   +2 more
openalex   +1 more source

The Iowa Perinatal Letter, January-February-March 2009, Vol. 30, no. 1 [PDF]

, 2009
This newsletter from The Department of Public Health about perinatal health care and ...

core  

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities

Advanced Science, EarlyView.
The tongue's anterior epithelium is maintained by region‐specific stem/progenitor cells, yet in vitro models are limited. Long‐term expanding organoids are developed from adult mouse anterior tongue that retain region‐specific identity, cellular diversity, and gene regulatory features. These organoids differentiate into keratinocytes, Merkel‐like cells,
Seok‐Young Kim, Laurens H. G. Verweij, Lin Lin, Johan H. van Es, Jay Slack, Chris Winkel, Tito Candelli, Philip Lijnzaad, Thanasis Margaritis, Gerben E. Breimer, Karin Sanders, Marc van de Wetering, Hans Clevers   +12 more
wiley   +1 more source

Vitamin B₁₂deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver [PDF]

, 2007
Shuhei Ebara, Motoyuki Nakao, Mayuko Tomoda, Ryoichi Yamaji, Fumio Watanabe, Hiroshi Inui, Yoshihisa Nakano   +6 more
openalex   +1 more source