Results 51 to 60 of about 14,153,510 (299)
Non-classical effects of vitamin D
Остеопороз и остеопатии, 2018 Since the discovery of vitamin D, interest in role of vitamin D in human body is consistently growing, and there is increasing evidence that vitamin D is not only essential to bone health but may also be involved in physiology of many other tissues. Thus
Ekaterina A. Pigarova +1 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Mìžnarodnij Endokrinologìčnij Žurnal, 2021 Despite its historical name, vitamin D is not a vitamin at all but a hormone that, when activated, is a metabolically active steroid fat-soluble hormone that acts on cellular receptors.
O.V. Kaminsky
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Vitamin D and cardiovascular diseases
, 2019 Vitamin D is a hormone with pleiotropic effects; it controls calcium homeostasis, immune response, hemodynamic wall stress (by inhibiting Renin Angiotensin Aldosterone System, RAAS, and modulating the endothelial function) and inflammation.
Grilli G. +6 more
core +1 more source
Vitamin D: The "sunshine" vitamin.
Journal of pharmacology & pharmacotherapeutics, 2012 Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency (VDD). This pandemic of hypovitaminosis D can mainly be attributed to lifestyle (for example, reduced outdoor activities) and environmental (for example, air pollution ...
Nair, Rathish, Maseeh, Arun
openaire +2 more sources
Bone Reports, 2018 Vitamin D is increasingly recognised to play an important role in normal muscle function. Low vitamin D status is associated with an increased risk of falls and proximal weakness. Since vitamin D deficiency is very common, and the signs are non-specific, it is important to maintain a high index of suspicion of vitamin D deficiency in patients with ...
Jenny E. Gunton, Christian M. Girgis
openaire +3 more sources
Vitamin D, vitamin D receptor and tissue barriers [PDF]
Tissue Barriers, 2013 Tissue barriers are critical in the pathogenesis of human diseases, such as atopic dermatitis, inflammatory bowel diseases, and various cancers. Preserving or restoring barrier functions of the epithelia cells is a therapeutic strategy to prevent and treat the illness. Mounting evidence indicates that vitamin D and the vitamin D receptor (VDR) play key
Zhang, Yong-guo, Wu, Shaoping, Sun, Jun
openaire +2 more sources
Effect of vitamin D supplementation on blood pressure:a systematic review and meta-analysis incorporating individual patient data [PDF]
, 2015 Importance Low levels of vitamin D are associated with elevated blood pressure (BP) and future cardiovascular events. Whether vitamin D supplementation reduces BP and which patient characteristics predict a response remain unclear.Objective To ...
Gepner, Adam D. +31 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source