Results 111 to 120 of about 75,687 (308)

Vitamin D and immunity [PDF]

, 2014
Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed,
Geldenhuys, Sian, Gorman, Shelley, Hart, Prue, Lucas, Robyn   +3 more
core   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Vitamin D3 concentration correlates with the severity of multiple sclerosis

International Journal of Preventive Medicine, 2013
Background: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This
Saeed Shahbeigi, Hossein Pakdaman, Seyed-Mohammad Fereshtehnejad, Elham Nikravesh, Nazanin Mirabi, Ghazal Jalilzadeh   +5 more
doaj  

Wellness and Multiple Sclerosis: The National MS Society Establishes a Wellness Research Working Group and Research Priorities [PDF]

, 2017
Background: People with multiple sclerosis (MS) have identified “wellness” and associated behaviors as a high priority based on “social media listening” undertaken by the National MS Society (i.e. the Society). Objective: The Society recently convened a
Bishop, Malachy, Casaccia, Patrizia, Chiaravalloti, Nancy D., Costello, Kathleen, Ehde, Dawn M., Fernhall, Bo, Geisser, Barbara, LaRocca, Nicholas G., McCully, Kevin K., Motl, Robert W., Mowry, Ellen M., Ng, Alex V., Plow, Matthew, Shinto, Lynne, Smith, Kathy E., Sullivan, Amy B.   +15 more
core   +3 more sources

Editorial: Vitamin D in Neurological Diseases: From Pathophysiology to Therapy [PDF]

, 2021
Joost Smolders, Amie Hiller, William Camu   +2 more
openalex   +1 more source

Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen, Aleksandr Barulin, Won Jong Yu, Jong‐Chan Park, Inki Kim   +4 more
wiley   +1 more source

Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

Clinical Interventions in Aging, 2018
Huijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School ...
Chen H, Liu Y, Huang G, Zhu J, Feng W, He J   +5 more
doaj  

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. [PDF]

, 2016
ObjectiveWe sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality.MethodsWe conducted mendelian randomization (MR ...
Alfredsson, Lars, Barcellos, Lisa F, Bäärnhielm, Maria, Gianfrancesco, Milena, Glymour, M Maria, Gyllenberg, Alexandra, Hedström, Anna Karin, Hillert, Jan, Kockum, Ingrid, Link, Jenny, Mok, Amanda, Olsson, Tomas, Quach, Hong, Rhead, Brooke, Schaefer, Catherine, Shao, Xiaorong, Shen, Ling   +16 more
core   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Mandibular Osteitis Revealing Calcium-Phosphate Imbalance in a Severely Disabled Child: A Case Report [PDF]

Batna Journal of Medical Sciences
Calcium-phosphate metabolism disturbances are common yet often under- recognized in children with severe disabilities. These imbalances can lead to serious bone disorders, including rickets, osteomalacia, and osteomyelitis.
Fouzia BOUNOUA, Djamila Djahida BATOUCHE, Djilali BATOUCHE, Karim HIRECHE   +3 more
doaj   +1 more source