Results 131 to 140 of about 2,758,793 (376)

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

Relationship of Serum Vitamin D Levels to the Severity of Migraine

Nigerian Journal of Medicine
Background Most studies done on Vitamin D deficiency in migraine focused more on headache frequency than intensity and severity of the condition. This study is aimed at determining the relationship between serum Vitamin D levels and severity of migraine ...
Simon Izuchukwu Ozomma, Sidney Kelechi Oparah, Mustapha Abudu Danesi, Francis Ibe Ojini, Roosevelt Amaobichukwu Anyanwu   +4 more
doaj   +1 more source

Vitamin D sensitivity to the immune responses and autoimmunity: A chemical network model study [PDF]

arXiv, 2013
Although Vitamin D is believed to be involved in a large number of immune responses our understanding of these processes at cellular level remained at infancy. We develop and solve a coarse grained kinetic network model to quantify the effects of variation of vitamin D on human immunity. The system of equations accounts for known inter-relation between
arxiv  

Vitamin D status in acute ischemic stroke: relation to initial severity and short-term outcome

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2019
BackgroundA growing body of evidence indicated that vitamin D has a potential protective role against neurovascular injury. Low serum vitamin D has been associated with increased risk for incident stroke and stroke fatality.ObjectiveThis study aimed to ...
E. Fahmy, S. Sharaf, H. Helmy, S. Sherif
semanticscholar   +1 more source

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study [PDF]

, 2014
Background: Friedreich's ataxia is a progressive degenerative disorder caused by deficiency of the frataxin protein. Expanded GAA repeats within intron 1 of the frataxin (FXN) gene lead to its heterochromatinisation and transcriptional silencing ...
Athanasopoulos, Stavros, Chan, Ping Kei, Festenstein, Richard, Giunti, Paola, Huson, Les, Law, Pui Pik, Leiper, James, Libri, Vincenzo, Loyse, Naomi, Mauri, Marta, Mohammad, Tariq, Natisvili, Theona, Parkinson, Michael H, Piper, Sophie, Ramesh, Aravind, Tam, Kin Tung, Yandim, Cihangir   +16 more
core   +1 more source

Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective The objective of this study was to evaluate the prognostic value of several muscle damage biomarkers. Methods Data from Piemonte and Valle d'Aosta Amyotrophic Lateral Sclerosis (PARALS) were considered for this study. Survival was defined as the time from diagnosis to death, tracheostomy, or the censoring date.
Rosario Vasta, Emanuele Koumantakis, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Filippo Vergnano, Jessica Mandrioli, Cecilia Simonini, Ilaria Martinelli, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Adriano Chiò   +18 more
wiley   +1 more source

Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2019
BackgroundMultiple epidemiological data showed a significant higher prevalence of hypovitaminosis D in patients with Parkinson’s disease (PD).ObjectivesTo assess the serum vitamin D level in patients with Parkinson’s disease and to investigate the ...
R. Soliman, M. Oraby, M. Hussein, Sanaa Abd El-Shafy, S. Mostafa   +4 more
semanticscholar   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Calculation of the Sun exposure time for the synthesis of vitamin D in Urcuquí, Ecuador [PDF]

Proceeding of Abstracts of IWBBIO, Francisco Ortu\~no Guzm\'an, Ignacio Rojas Ru\'iz (Comp.), ISBN: 978-84-16929-58-0 (2017), 27, 2017
The synthesis of vitamin D is strongly linked to the availability of solar energy. For a long time, it was clear that using the erythemal irradiances is a good choice to calculate the exposure time. Several authors argue that this method of minimum exposure time overestimates the calculation of the solar irradiance of vitamin D.
arxiv  

Serum vitamin D levels in acute stroke patients

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2019
BackgroundVitamin D deficiency has been proposed as a risk factors of cerebrovascular stroke.ObjectivesThe aim of this study was firstly, to assess the serum level of vitamin D in cerebral stroke patients and secondly, to examine if its deficiency was ...
F. Selim, Rasha M. Fahmi, Ayman E. Ali, Nermin Raafat, Ahmed F. Elsaid   +4 more
semanticscholar   +1 more source