Results 131 to 140 of about 77,458 (359)

Diabetic peripheral neuropathy: the potential role of vitamin D deficiency

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2019
BackgroundVitamin D is well known for its role in promoting calcium and phosphorus absorption and is recently associated with various neurological disorders.ObjectiveTo study the possible relation between vitamin D deficiency and diabetic peripheral ...
M. Oraby, Mona Abu Srie, S. Abdelshafy, E. Elfar   +3 more
semanticscholar   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

Angewandte Chemie, EarlyView.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, EarlyView.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

Vitamin D and immunity [PDF]

, 2014
Vitamin D deficiency has been linked to an increased risk of a wide range of adverse health outcomes. The active form of vitamin D has an important role in calcium metabolism and in bone mineralisation, but the evidence for other health outcomes is mixed,
Geldenhuys, Sian, Gorman, Shelley, Hart, Prue, Lucas, Robyn   +3 more
core   +1 more source

Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2019
BackgroundMultiple epidemiological data showed a significant higher prevalence of hypovitaminosis D in patients with Parkinson’s disease (PD).ObjectivesTo assess the serum vitamin D level in patients with Parkinson’s disease and to investigate the ...
R. Soliman, M. Oraby, M. Hussein, Sanaa Abd El-Shafy, S. Mostafa   +4 more
semanticscholar   +1 more source

Wellness and Multiple Sclerosis: The National MS Society Establishes a Wellness Research Working Group and Research Priorities [PDF]

, 2017
Background: People with multiple sclerosis (MS) have identified “wellness” and associated behaviors as a high priority based on “social media listening” undertaken by the National MS Society (i.e. the Society). Objective: The Society recently convened a
Bishop, Malachy, Casaccia, Patrizia, Chiaravalloti, Nancy D., Costello, Kathleen, Ehde, Dawn M., Fernhall, Bo, Geisser, Barbara, LaRocca, Nicholas G., McCully, Kevin K., Motl, Robert W., Mowry, Ellen M., Ng, Alex V., Plow, Matthew, Shinto, Lynne, Smith, Kathy E., Sullivan, Amy B.   +15 more
core   +3 more sources