Results 121 to 130 of about 15,055,784 (304)
Advanced Science, EarlyView.Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
wiley +1 more source
Vitamin D deficiency in patients with tuberculosis: prevalence, risk factors and treatment outcomes
Monaldi Archives for Chest DiseaseAlthough vitamin D deficiency is common in tuberculosis (TB) patients, several studies demonstrated that it may not influence treatment response. The aim of this study was to evaluate the prevalence and risk factors of vitamin D deficiency in a group of
Maiana Silva da Silva +7 more
doaj +1 more source
TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains
Advanced Science, EarlyView.Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang +14 more
wiley +1 more source
Vitamin D: no efficacy without deficiency. What?s new?
, 2019 Vitamin D: no efficacy without deficiency.
Gatti, D., Rossini, M., Fassio, A.
core +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations
, 2015 Catherine A Peterson Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, MO, USA Abstract: Vitamin D deficiency and childhood obesity have been classified as epidemics throughout the world, and both share some ...
Peterson CA
core
Towards a Compositional Framework for Describing Human Phenotypes
Advanced Science, EarlyView.The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu +11 more
wiley +1 more source
Advanced Science, EarlyView.The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng +10 more
wiley +1 more source
Human Nutrition & MetabolismA high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency.
Siew-Siew Lee +5 more
doaj +1 more source
Functional MXene Inks for Printed Electronics: Chemistry, Rheology, and Devices
Advanced Science, EarlyView.Functional MXene inks are emerging as building blocks for MXetronics, connecting MXene synthesis, surface functionalization, ink formulation, and advanced printing with device‐level applications. This review maps how composition, stability, rheology, and processability govern printed structures and enable high‐performance sensors, energy‐storage ...
Shahzaib Ali +6 more
wiley +1 more source