Results 261 to 270 of about 184,846 (305)

Vitamin D receptor and analogs

Seminars in Nephrology, 2004
In chronic kidney disease (CKD), high circulating levels of parathyroid hormone (PTH) cause osteitis fibrosa, bone loss, and cardiovascular complications that increase morbidity and mortality. Impaired production of 1,25-dihydroxyvitamin D (calcitriol), the hormonal form of vitamin D, is a major contributor to the generation and maintenance of ...
Adriana S, Dusso, Ravi, Thadhani, Eduardo, Slatopolsky   +2 more
openaire   +2 more sources

Vitamin D Receptor Activators

The International Journal of Artificial Organs, 2009
The fields for clinical employment of vitamin D analogs are growing and under active evaluation in different medical specialties, ranging from dermatology to immunology and oncology. In this review we provide a brief description of the drugs that have been developed more specifically for the treatment of secondary hyperparathyroidism (SH) associated ...
MAZZAFERRO, SANDRO, PASQUALI M, CONTE, CARMINA, MANDANICI G, MUCI M, LAVINI R.   +5 more
openaire   +3 more sources

Vitamin D Analogs as Modulators of Vitamin D Receptor Action

Current Topics in Medicinal Chemistry, 2003
The natural calcium-regulating hormone 1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) is a secosteroid that offers organic chemists many sites for modifying structural and/or functional groups. Such modifications alter the chemistry, stereochemistry, and biological properties of the natural hormone.
Sara, Peleg, Gary H, Posner
openaire   +2 more sources

The Function of Vitamin D Receptor in Vitamin D Action

Journal of Biochemistry, 2000
Vitamin D has roles in a variety of biological actions such as calcium homeostasis, cell proliferation and cell differentiation to many target tissues. Most of these biological actions of vitamin D are now considered to be exerted through the nuclear vitamin D receptor (VDR)-mediated control of target genes.
openaire   +2 more sources

Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis

2011
Vitamin D plays a major role in bone mineral density and calcium homeostasis. Apart from its classical action, the active form of vitamin D [1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))] influences the innate and adaptive immune functions through vitamin D receptor (VDR) that are present in various cells of the immune system.
openaire   +3 more sources

Vitamin D/vitamin D receptor, autophagy, and infection.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022
Vitamin D plays an important role in mineral and bone homeostasis, immune responses, cardiovascular function and keratinocyte proliferation and differentiation. Vitamin D performs most of its functions by binding to vitamin D receptors (VDR), which interact with other intracellular signaling pathways to regulate bone metabolism, inflammation, immunity,
Yu, Hou, Jinghui, Li, Chao, Deng
openaire   +1 more source

Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation

Journal of Endocrinological Investigation, 2010
Chronic inflammation is now considered a determinant of benign prostatic hyperplasia (BPH), promoting, together with the hormonal milieu, prostate overgrowth and lower urinary tract symptoms (LUTS). Prostatic urethra actively participates in determining progression of LUTS associated with BPH.To investigate the expression of the vitamin D receptor (VDR)
COMEGLIO, PAOLO, A. K. Chavalmane, FIBBI, BENEDETTA, FILIPPI, SANDRA, M. Marchetta, MARINI, MIRCA, MORELLI, ANNAMARIA, G. Penna, VIGNOZZI, LINDA, VANNELLI, GABRIELLA, L. Adorini, MAGGI, MARIO   +11 more
openaire   +2 more sources

Ligand recognition by the vitamin D receptor

Bioorganic & Medicinal Chemistry, 2001
Three-dimensional structure of the ligand binding domain (LBD) of the vitamin D receptor (VDR) docked with the natural ligand 1 alpha,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] has been mostly solved by the X-ray crystallographic analysis of the deletion mutant (VDR-LBD Delta 165-215).
M, Choi, K, Yamamoto, H, Masuno, K, Nakashima, T, Taga, S, Yamada   +5 more
openaire   +2 more sources

Vitamin D Receptor Polymorphisms and Cancer

2020
Increasing scientific evidence supports the link between vitamin D and cancer risk. The active metabolite 1,25(OH)2D exerts its activity by binding to the vitamin D receptor (VDR), an intracellular receptor that mediates transcriptional activation and repression of target genes. The binding of 1,25(OH)2D to VDR is able to regulate hundreds of different
Patrizia, Gnagnarella, Sara, Raimondi, Valentina, Aristarco, Harriet Ann, Johansson, Federica, Bellerba, Federica, Corso, Sara, Gandini   +6 more
openaire   +2 more sources

Vitamin D Receptor–DNA Interactions

2004
The vitamin D receptor (VDR) is a member of the steroid and nuclear hormone receptor superfamily of eukaryotic transcription factors and binds target DNA, or response elements, as a homodimer or heterodimer with the 9-cis retinoid X receptor (RXR).
Paul L, Shaffer, Daniel T, Gewirth
openaire   +2 more sources