Results 91 to 100 of about 275,782 (257)

25-Hydroxyvitamin D Threshold for the Effects of Vitamin D Supplements on Bone Density:Secondary Analysis of a Randomized Controlled Trial [PDF]

, 2018
Most trials of vitamin D supplementation have shown no benefits on bone density (BMD), though severe vitamin D deficiency causes osteomalacia which is associated with profound BMD deficits.
Abrahamsen, Andersen, Avenell, Bacon, Bailey, Bolland, Bolland, de la Hunty, El-Desouki, Islam, Lieben, Lips, Lucas, Macdonald, Malabanan, Reid, Reid, Tang   +17 more
core   +2 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

The role of vitamin D in the development and prevention of migraine: a review

Quality in Sport
Introduction and Purpose  Migraine is a widespread neurological disorder characterized by severe, pulsating headaches often accompanied by nausea, vomiting, and hypersensitivity to light and sound.
Joanna Olszak, Karolina Zalewa, Wojciech Kapłan, Dominika Orłowska, Lidia Bartoszek   +4 more
doaj   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Vitamin D supplementation after the menopause

Therapeutic Advances in Endocrinology and Metabolism, 2020
The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions
Faustino R. Pérez-López, Peter Chedraui, Stefan Pilz   +2 more
doaj   +1 more source

Lipid-soluble Vitamins A, D, and E in HIV-Infected Pregnant women in Tanzania. [PDF]

, 2010
There is limited published research examining lipid-soluble vitamins in human immunodeficiency virus (HIV)-infected pregnant women, particularly in resource-limited settings.
A Coutsoudis, A Prentice, AJ Roodenburg, B Specker, CM Veldman, D J Hunter, D Spiegelman, D Spiegelman, D Suharno, E Hertzmark, E L Giovannucci, E Villamor, EM Knight, F Ahmed, F M Mugusi, G Antelman, G I Msamanga, G Mulokozi, GA Keverenge-Ettyang, GC Di Renzo, GT Bondevik, H Babbe, H Friis, J Reichrath, JM Baeten, KN Evans, KP West Jr, LC Chappell, LC Stene, LH Allen, LM Bodnar, MF Holick, MF Picciano, MK Horwitt, MR Loeken, O Miettinen, P Christian, P Haga, P Zvandasara, PT Liu, R Kupka, RD Semba, RJ Stoltzfus, S Aboud, S de Pee, S Durrleman, S Mehta, S Yang, SG Hinderaker, SN Meydani, TO Scholl, US Govindarajulu, W Fawzi, W Urassa, W W Fawzi, WHO, WW Fawzi, WW Fawzi, Y Wang, Y Wondmikun, Z Bar-Shavit, Z Zaman   +61 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

The road not so travelled : Should measurement of vitamin D epimers during pregnancy affect our clinical decisions? [PDF]

, 2017
Observational studies suggest an adverse effect of maternal hypovitaminosis D during pregnancy. However, intervention studies failed to show convincing benefit from vitamin D supplementation during pregnancy.
Declan Naughton, Elena Angeloudi, Kalliopi Kotsa, Kovacs, Pantelis Zebekakis, Spyridon Karras   +5 more
core   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source