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Vitamin K and Vitamin K Antagonists
2020Vitamin Κ was discovered by Henrik Dam in 1929 in studies of sterol metabolism in chicks fed fat-free diets (1). The antihemorrhagic fat-soluble agent was called vitamin Κ, Κ being short for "Koagulation" (the German word for coagulation). Since then there have been two major eras of extensive research on this vitamin.
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Scandinavian Journal of Clinical and Laboratory Investigation, 2017
Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions ...
Sofia, Dahlberg +2 more
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Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions ...
Sofia, Dahlberg +2 more
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Pediatrics, 1985
To the Editor.— The article by Payne and Hasegawa1 on vitamin K deficiency of the newborn correctly stresses the existence of differences between vitamin K deficiency and Coumadin effect. This has been somewhat forgotten in important studies on the mode of action of prothrombin.2-4 Modern techniques as the Echis time5 and certain ...
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To the Editor.— The article by Payne and Hasegawa1 on vitamin K deficiency of the newborn correctly stresses the existence of differences between vitamin K deficiency and Coumadin effect. This has been somewhat forgotten in important studies on the mode of action of prothrombin.2-4 Modern techniques as the Echis time5 and certain ...
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Current Opinion in Pediatrics, 1994
Discussion about the efficacy and safety of vitamin K prophylaxis has recently restarted. In this review, new developments in diagnosis of vitamin K deficiency (including vitamin K plasma levels and protein induced by vitamin K absence [PIVKA]-II detection) and therapy of early, classic, and late hemorrhagic disease of the newborn are highlighted ...
M W, Huysman, P J, Sauer
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Discussion about the efficacy and safety of vitamin K prophylaxis has recently restarted. In this review, new developments in diagnosis of vitamin K deficiency (including vitamin K plasma levels and protein induced by vitamin K absence [PIVKA]-II detection) and therapy of early, classic, and late hemorrhagic disease of the newborn are highlighted ...
M W, Huysman, P J, Sauer
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2008
Vitamin K is a collective term for lipid-like naphthoquinone derivatives synthesized only in eubacteria and plants and functioning as electron carriers in energy transduction pathways and as free radical scavengers maintaining intracellular redox homeostasis.
Johannes, Oldenburg +3 more
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Vitamin K is a collective term for lipid-like naphthoquinone derivatives synthesized only in eubacteria and plants and functioning as electron carriers in energy transduction pathways and as free radical scavengers maintaining intracellular redox homeostasis.
Johannes, Oldenburg +3 more
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The Journal of Pediatrics, 1985
THE TERM "hemorrhagic disease of the newborn" was first used in 1894 when Townsend ~ reported 50 infants with bleeding during the first two weeks of life. The hemorrhage usually began on the second o? third day of life and most commonly was from the gastrointestinal tract.
P A, Lane, W E, Hathaway
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THE TERM "hemorrhagic disease of the newborn" was first used in 1894 when Townsend ~ reported 50 infants with bleeding during the first two weeks of life. The hemorrhage usually began on the second o? third day of life and most commonly was from the gastrointestinal tract.
P A, Lane, W E, Hathaway
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1998
The discovery of vitamin K can be largely attributed to the Danish scientist Henrik Dam, whose work on sterol metabolism in chicks required the feeding of carefully controlled diets, some of which were depleted in lipids (Dam, 1929). This often caused internal hemorrhages and other symptoms similar to scurvy, but which Dam showed to be incurable by ...
P, Newman, M J, Shearer
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The discovery of vitamin K can be largely attributed to the Danish scientist Henrik Dam, whose work on sterol metabolism in chicks required the feeding of carefully controlled diets, some of which were depleted in lipids (Dam, 1929). This often caused internal hemorrhages and other symptoms similar to scurvy, but which Dam showed to be incurable by ...
P, Newman, M J, Shearer
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Blood, 2006
Abstract More than 21 million prescriptions for warfarin are written yearly in the US. Yet, in spite of its importance, vitamin K epoxide reductase (VKOR), the target of warfarin, has resisted purification since its identification in 1972.
Pei-hsuan Chu +3 more
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Abstract More than 21 million prescriptions for warfarin are written yearly in the US. Yet, in spite of its importance, vitamin K epoxide reductase (VKOR), the target of warfarin, has resisted purification since its identification in 1972.
Pei-hsuan Chu +3 more
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Clinics in Dermatology
Systemic vitamins K1 and K2 exhibit multifaceted functions beyond coagulation, particularly in pseudoxanthoma elasticum (PXE) and conditions resembling PXE. Disturbances in the vitamin K pathway contribute to elastic fiber fragmentation and tissue mineralization.
Monika, Bapna, Min, Deng
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Systemic vitamins K1 and K2 exhibit multifaceted functions beyond coagulation, particularly in pseudoxanthoma elasticum (PXE) and conditions resembling PXE. Disturbances in the vitamin K pathway contribute to elastic fiber fragmentation and tissue mineralization.
Monika, Bapna, Min, Deng
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Vitamin K Metabolism in a Patient Resistant to Vitamin K Antagonists
Haemostasis, 2009We investigated various pharmacokinetic and pharmacody-namic parameters in a 63-year-old man, resistant to warfarin, fluindione, acenocoumarol and phenprocoumon. Daily doses of up to 30 mg of the long-acting phenprocoumon yielded a drug concentration of 85 mg/1 (usual range 1-5 mg/1) but the international normalized ratio remained around 1.
A, Keréveur +8 more
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