Results 1 to 10 of about 277,482 (119)

VKORC1L1–mediated vitamin K recycling counters ferroptosis to promote endothelial repair [PDF]

Scientific Reports
Vitamin K is classically known for hepatic γ-carboxylation via VKORC1, yet accumulating evidence suggests broader redox-regulatory roles. Here, we characterize the VKORC1 paralogue VKORC1L1 as an anti-oxidative enzyme that couples the vitamin K cycle to ...
Elena Repges, Adem Aksoy, Katrin J. Czogalla-Nitsche, Andreas Zietzer, Cornelius Müller, Johannes Oldenburg, Sebastian Zimmer, Georg Nickenig, Vedat Tiyerili, Muntadher Al Zaidi   +9 more
doaj   +2 more sources

Effect of Vitamin K on Mothers and Neonates [PDF]

Minia Journal of Medical Research, 2022
Vitamin K was first discovered in the early 1930s by the Danish biochemist Henrik Dam who observed while studying cholesterol metabolism in chickens that chicks fed with a diet free of sterols and low in fat tended to develop subcutaneous and ...
Beshoy Asaad, Reem Abdel Aziz, Heba Hassan, Essa Mahmoud   +3 more
doaj   +1 more source

Prevalence of subclinical Vitamin K deficiency in early infancy in exclusively breast-fed term infants

Journal of Marine Medical Society, 2023
Background: Late Vitamin K deficiency bleeding, is a disease of exclusively breast-fed infants attributable to poor content of Vitamin K in breast milk.
Gitanjali Jain, K M Adhikari, Gautam Kumar Vasnik, Daljit Singh, Venkatesan Somasundaram, Rakesh Gupta, Puja Dudeja, Subhash Chandra Shaw   +7 more
doaj   +1 more source

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

Nature Communications, 2023
The authors develop a Vitamin K-dependent apoptotic reporter cell line for large-scale screening of enzymes associated with Vitamin K-dependent carboxylation and identify ferroptosis suppressor protein 1 (FSP1) as responsible for warfarin-resistant ...
Da-Yun Jin, Xuejie Chen, Yizhou Liu, Craig M. Williams, Lars C. Pedersen, Darrel W. Stafford, Jian-Ke Tie   +6 more
doaj   +1 more source

Prevalence and treatment of vitamin K deficiency in paediatric patients with recessive dystrophic epidermolysis bullosa‐severe subtype

Skin Health and Disease, 2021
Introduction Patients with recessive dystrophic epidermolysis bullosa‐severe subtype (RDEB‐S) are at risk of vitamin K deficiency, potentially causing abnormal clotting, excessive bleeding, poor bone metabolism and abnormal vascular calcification.
N. Yerlett, G. Petrof, K. Holsgrove, A. Martinez   +3 more
doaj   +1 more source

Efficacy and safety of sorafenib plus vitamin K treatment for hepatocellular carcinoma: A phase II, randomized study

Cancer Medicine, 2021
The previous retrospective study suggested that dosing vitamin K may enhance the anticancer action of sorafenib against hepatocellular carcinoma. To confirm it, we performed a phase II, randomized, open‐label study. Patients with hepatocellular carcinoma
Yoshimichi Haruna, Takayuki Yakushijin, Seiichi Kawamoto   +2 more
doaj   +1 more source

Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study

Applied Sciences, 2023
(1) Background: Vitamin K deficiency is a common feature of chronic kidney disease (CKD), leading to impaired bone quality and an increased risk of vascular calcifications.
Marcel Palamar, Iulia Grosu, Adalbert Schiller, Ligia Petrica, Madalina Bodea, Alexandru Sircuta, Cornel Rusan, Daniela Maria Tanasescu, Flaviu Bob   +8 more
doaj   +1 more source

Extraction and Determination of Vitamin K₁ in Foods by Ultrasound-Assisted Extraction, SPE, and LC-MS/MS

Molecules, 2020
Vitamin K1 is one of the important hydrophobic vitamins in fat-containing foods. Traditionally, lipase is employed in the determination of vitamin K1 to remove the lipids, which makes the detection complex, time-consuming, and insensitive. In this study,
Yueqing Xu, Liangxiao Zhang, Ruinan Yang, Xu Yu, Li Yu, Fei Ma, Hui Li, Xiupin Wang, Peiwu Li   +8 more
doaj   +1 more source

Vitamin K enhances the production of brain sulfatides during remyelination. [PDF]

PLoS ONE, 2018
Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system.
Daniela C Popescu, He Huang, Naveen K Singhal, Leah Shriver, Jennifer McDonough, Robert J Clements, Ernest J Freeman   +6 more
doaj   +1 more source

Biofortification of Chicken Eggs with Vitamin K—Nutritional and Quality Improvements

Foods, 2020
National nutrition surveys have shown that over half of all adults in Ireland, the United Kingdom (UK), and the United States of America (USA) have low vitamin K intakes.
Siobhan M. O’Sullivan, M. Elizabeth E. Ball, Emma McDonald, George L. J. Hull, Martin Danaher, Kevin D. Cashman   +5 more
doaj   +1 more source