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Advances in Nutrition, 2022 Vitamin K is a fat-soluble vitamin and a significant hydrophobic signaling molecule, like vitamins A and D. Besides its classical functions as a cofactor of γ-glutamyl carboxylase, which catalyzes the γ-carboxylation of vitamin K-dependent proteins ...
M Kyla Shea, Sarah L Booth
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Vitamin K and Osteoporosis [PDF]
Nutrients, 2020 Vitamin K acts as a coenzyme of carboxylase, catalyzing the carboxylation of several vitamin K dependent proteins. Beyond its well-known effects on blood coagulation, it also exerts relevant effects on bone and the vascular system. In this review, we point out the relevance of an adequate vitamin K intake to obtain sufficient levels of carboxylated ...
Fusaro, Maria +16 more
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Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH 2 [PDF]
Proceedings of the National Academy of Sciences, 2006 More than 21 million prescriptions for warfarin are written yearly in the U.S. Despite its importance, warfarin's target, vitamin K epoxide reductase (VKOR), has resisted purification since its identification in 1972. Here, we report its purification and reconstitution.
Pei-Hsuan, Chu +3 more
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BMJ, 1994 EDITOR, - Jim Slattery commits a serious error in suggesting that breastfeeding mothers who experience major difficulties during the early weeks should give their babies supplementary formula milk.1 This is bad advice and contrary to the results of research on establishing breast feeding.
M, Newburn, R, Dodds
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Archives of Disease in Childhood, 1999 Editor,—I would like to raise two points about the editorial by Tripp and McNinch.1 First, they quote the incidence of vitamin K deficiency bleeding among babies given no prophylaxis as 10/1000 live births, citing the findings of the 1991 British Paediatric Surveillance Unit study.2 Table III of that paper quoted …
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Journal of Thrombosis and Haemostasis, 2005 Post-translational modification of glutamate to gamma carboxyl glutamate is required for the activity of vitamin K-dependent proteins. Carboxylation is accomplished by the enzyme gamma glutamyl carboxylase (GGCX) which requires the propeptide-containing substrate and three co-substrates: reduced vitamin K, CO2, and O2.
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Clinical Cases in Mineral and Bone Metabolism, 2017 Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification.
Fusaro Maria +4 more
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Prophylactic Vitamin K for Vitamin K Deficiency Bleeding of the Newborn
Farmacia Hospitalaria (English Edition), 2011 The administration of vitamin K immediately after birth has shown a significant decrease in the incidence of newborn bleeding, but there is not enough evidence to determine the most appropriate method of administration. The objective of this review is to determine the effectiveness of orally administered vitamin K compared to the intramuscular route in
J E, Martín-López +5 more
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