Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis. [PDF]
PLoS ONE, 2015 BackgroundRoutine use of antifibrinolytic agents in spine surgery is still an issue of debate.ObjectiveTo gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon ...
Meng Wang +2 more
doaj +4 more sources
Antifibrinolytic agents in traumatic haemorrhage. [PDF]
PLoS Medicine, 2005 Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. Could anti fibrinolytics reduce the death rate?
Tim Coats +3 more
doaj +10 more sources
Efficacy and safety of using antifibrinolytic agents in spine surgery: a meta-analysis. [PDF]
PLoS ONE, 2013 PURPOSE: Spine surgery, particularly reconstructive surgery, can be associated with significant blood loss, and blood transfusion. Antifibrinolytic agents are used routinely to reduce bleeding in cardiac, orthopaedic, and hepatic surgery.
Chaoqun Yuan, Hailong Zhang, Shisheng He
doaj +2 more sources
Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis [PDF]
Chinese Medical Journal, 2019 . Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan +7 more
doaj +2 more sources
Effectiveness and safety of antifibrinolytic agents in off-pump coronary artery bypass grafting: a systematic review and meta-analysis [PDF]
Brazilian Journal of AnesthesiologyBackground: Coronary Artery Bypass Grafting (CABG) is the most widely used cardiac intervention and can be accomplished without an extracorporeal circulation off-pump.
João Lucas W.C. Marchesani +5 more
doaj +2 more sources
Antifibrinolytic agents in current anaesthetic practice [PDF]
British Journal of Anaesthesia, 2013 Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury has been consistently shown to reduce postoperative or traumatic bleeding. There is also some evidence for a reduction of perioperative blood transfusion.
A A Klein
exaly +3 more sources
Antifibrinolytic agents for the prevention of postpartum hemorrhage
Thrombosis Update, 2021 Acute obstetric coagulopathy secondary to postpartum hemorrhage (PPH) is associated with poor outcome. There is evidence that Tranexamic Acid (TA), an antifibrinolytic drug, is an efficient tool of patient blood management in association with uterotonics
Anne-Sophie Bouthors +3 more
doaj +2 more sources
Subcutaneous Tranexamic Acid Achieves Comparable Serum Concentrations to Intramuscular Administration During Haemorrhagic Shock in a Swine Model. [PDF]
Acta Anaesthesiol ScandABSTRACT Background Tranexamic acid is an antifibrinolytic agent reducing mortality when administered to trauma patients with haemorrhagic shock. This mortality reduction is time sensitive. Increased intramuscular dose administration has proven an effective alternative to intravenous administration in several studies and is used by some emergency ...
Lynghaug T +6 more
europepmc +2 more sources
Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
Ilaria De Simone +9 more
doaj +2 more sources
Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children [PDF]
The Cochrane Library, 2016 Ewan D Mcnicol, Roman Schumann
exaly +2 more sources