Results 31 to 40 of about 7,770 (215)

Plasmin Inhibitor in Health and Diabetes: Role of the Protein as a Therapeutic Target

TH Open, 2022
The vascular obstructive thrombus is composed of a mesh of fibrin fibers with blood cells trapped in these networks. Enhanced fibrin clot formation and/or suppression of fibrinolysis are associated with an increased risk of vascular occlusive events ...
Basmah Alsayejh, Noppadol Kietsiriroje, Mansour Almutairi, Katie Simmons, Nikoletta Pechlivani, Sreenivasan Ponnambalam, Ramzi A. Ajjan   +6 more
doaj   +1 more source

Safety and Efficacy of Hospital Utilization of Tranexamic Acid in Civilian Adult Trauma Resuscitation [PDF]

, 2020
Introduction: Patients with trauma-induced coagulopathies may benefit from the use of antifibrinolytic agents, such as tranexamic acid (TXA). This study evaluated the safety and efficacy of TXA in civilian adults hospitalized with traumatic hemorrhagic ...
Borger, Rodney, Chandwani, Deepak, Comunale, Mark E., Dong, Fanglong, Inaba, Kenji, Lowe, Andrew, Neeki, Michael, Powell, Joe, Quispe, Juan, Rabiei, Massoud, Salameh, Joseph, Toy, Jake, Vara, Richard, Wong, David   +13 more
core  

The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial [PDF]

, 2010
Background Each year, worldwide about 530,000 women die from causes related to pregnancy and childbirth. Of the deaths 99% are in low and middle income countries.
Haleema Shakur, Diana Elbourne, Metin Gülmezoglu, Zarko Alfirevic, Carine Ronsmans, Elizabeth Allen, Ian Roberts, World Health Organization, C AbouZahr, A Lalonde, C Ronsmans, EJ Kongnyuy, KS Khan, AJ Ekeroma, World Health Organisation, C Taylor, C AbouZahr, World Health Organization, CJ Dunn, National Collaborating Centre for Womens and Childrens Health, PR Ferrer, D Ketley, CR Prentice, M Hellgren, J Bonnar, AC Bolte, RB Gherman, P Lindqvist, MR Toglia, JA Heit, R Peto, JC Horrow, DAMOCLES Study Group, JL Haybittle, R Peto, D Moher   +35 more
core   +3 more sources

Dental extraction in patients rece iving dual antiplatelet therapy [PDF]

, 2015
Background: Dual antiplatelet therapy consists of administering antiplatelet (antiaggregant) drugs (clopidogrel and aspirin) to prevent thrombotic processes, as a preventative measure in patients with acute coronary disease, or in patients ...
Calvo Guirado, José Luis, González Jaranay, Maximino, Gómez Moreno, Gerardo, Moreu Burgos, Gerardo, Peñarrocha Diago, Miguel, Rodriguez Archilla, Alberto, Sánchez Cobo, Paulino, Sánchez Palomino, Paulino   +7 more
core   +2 more sources

Coagulation and Bleeding Management in Pediatric Extracorporeal Membrane Oxygenation: Clinical Scenarios and Review

Frontiers in Medicine, 2019
Extracorporeal membrane oxygenation (ECMO) is a life-saving procedure that requires careful coagulation management. Indications for ECMO continue to expand, leading to more complicated patients treated by ECMO teams.
Lisa A. Hensch, Lisa A. Hensch, Shiu-Ki Rocky Hui, Shiu-Ki Rocky Hui, Jun Teruya, Jun Teruya   +5 more
doaj   +1 more source

Minimal Dose of Tranexamic Acid Is Effective in Reducing Blood Loss in Complex Spine Surgeries: A Randomized Double-Blind Placebo Controlled Study [PDF]

Asian Spine Journal, 2018
Study Design A randomized double-blind placebo controlled study. Purpose In the present study, we aimed to assess the efficacy of tranexamic acid (TXA) in reducing blood loss after laminectomy and posterolateral fusion of the spine.
Moslem Shakeri, Firooz Salehpour, Ghaffar Shokouhi, Kamkar Aeinfar, Javad Aghazadeh, Farhad Mirzaei, Seyed Ahmad Naseri Alavi   +6 more
doaj   +1 more source

Evolving perspectives on blood transfusion in obstetric hemorrhage: a narrative review [PDF]

Korean Journal of Anesthesiology
Globally, postpartum hemorrhage is still among the most significant factors in preventable maternal morbidity and mortality. Although early recognition and intervention have improved with advances in obstetric care, transfusion practices are often based ...
Yoon Ji Choi, Sang Hun Kim
doaj   +1 more source

Tranexamic acid therapy in pediatric cardiac surgery:a single center study [PDF]

, 2012
Background: We conducted a retrospective study of cyanotic and acyanotic patients undergoing cardiopulmonary bypass to determine the effect of tranexamic acid on blood loss and blood products administered during the operation in pediatric cardiac surgery.
Cioffi S, Giordano R, MANNACIO, VITO ANTONIO, Mucerino M, PALMA, GAETANO, Palumbo S, Poli V, Russolillo V, VOSA, CARLO   +8 more
core   +1 more source

On‐demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII [PDF]

, 2011
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90042/1/j.1365-2516.2011.02612.x ...
Abshire, Abshire, Abshire, Astermark, Berntorp, Beyer, Beyer, Croom, DiMichele, Escobar, Gringeri, Hay, Hay, Hedner, Kavakli, Key, Levi, Lindley, Lusher, Lusher, Lusher, Mathew, Monroe, Nair, Ovanesov, Paisley, Perez Bianco, Pruthi, Salaj, Santagostino, Santagostino, Shapiro, Soucie, Teitel, Tengborn, Valentino, Villar, Young, Young   +38 more
core   +1 more source

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]

, 2013
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila, Kolev, K., Komorowicz, E., Longstaff, C., Machovich, R., Rottenberger, Z., Szabó, László, Varga, Zoltán   +7 more
core   +5 more sources