Results 31 to 40 of about 5,590 (131)

Tranexamic acid dosing strategies and blood loss reduction in multilevel spine surgery: A systematic review and network meta-analysis

North American Spine Society Journal, 2021
Background: For adults undergoing complex, multilevel spinal surgery, tranexamic acid (TXA) is an antifibrinolytic agent used to reduce blood loss. The optimal dosing of intravenous TXA remains unclear.
Roman Rahmani, Amy Singleton, Zachary Fulton, John M. Pederson, Thomas Andreshak   +4 more
doaj   +1 more source

Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review

Haemophilia, EarlyView.
ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson, Roy Khalife, Kelsey Uminski   +2 more
wiley   +1 more source

Efficacy and Safety of Combined Carbazochrome Sodium Sulfonate and Tranexamic Acid for Blood Loss Control in Patients Undergoing Total Hip Arthroplasty: A Systematic Review and Meta-Analysis [PDF]

Iranian Journal of Medical Sciences
Background: Total hip arthroplasty (THA) relieves pain and restores function in severe hip arthritis and other painful hip disorders. THA is successful; however, it involves significant perioperative blood loss, which can lead to complications and ...
Mohamed Wahb, Mohamed Elghouneimy, Miqdad Qandeel, Abdullah Elrefae, Mohamed H. Khater, Mirna Morad Mashhour, Ali Mohamed Seif, Mohammad Amgad Seddek, Omar Ahmed Abdelwahab   +8 more
doaj   +1 more source

Oral Soft Tissue Biopsy in Patients Receiving Direct Oral Anticoagulants: A Prospective Cohort Study on Bleeding Outcomes

Oral Diseases, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are the first‐line therapy for stroke prevention in non‐valvular atrial fibrillation and venous thromboembolism. While evidence supports their continuation during routine dental procedures such as tooth extractions, data on oral soft tissue biopsies remain limited.
Rossana Izzetti, Chiara Cinquini, Antonio Barone, Marco Nisi   +3 more
wiley   +1 more source

Antifibrinolytics in cardiac surgery

Annals of Cardiac Anaesthesia, 2013
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Achal Dhir
doaj   +1 more source

Salts of S-(+)-Ibuprofen Formed via Its Reaction with the Antifibrinolytic Agents Aminocaproic Acid and Tranexamic Acid: Synthesis and Characterization

Crystals, 2023
The paucity of multi-component compounds containing the non-steroidal anti-inflammatory drug (NSAID) S-(+)-ibuprofen (S-IBU) in combination with other drugs prompted the present study, which describes 1:1 salts of this active pharmaceutical ingredient ...
Hannah M. Frösler, Humbelani S. Ramulumo, Cesarina Edmonds-Smith, Mino R. Caira   +3 more
doaj   +1 more source

Prioritising parameters to minimise blood transfusions for postpartum haemorrhage: A machine learning study using national population data

Transfusion Medicine, EarlyView.
Abstract Background Postpartum haemorrhage (PPH) accounts for approximately 27% of maternal deaths worldwide and often requires blood transfusion, along with its associated risks. In resource‐rich settings like South Korea, transfusion disparities persist, highlighting the need for predictive tools to optimise patient blood management (PBM).
Ki Hoon Ahn, Yu‐Min Choi, Kwang‐Sig Lee   +2 more
wiley   +1 more source

Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma

Research and Practice in Thrombosis and Haemostasis
Background: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
Ilaria De Simone, Kieran Pocknell, Samia Tufaha, Joke Konings, Mark Roest, Alisa S. Wolberg, Claire S. Whyte, Nicola J. Mutch, Bas de Laat, Dana Huskens   +9 more
doaj   +1 more source

Just one thing to reduce bleeding: Put tranexamic acid on the safe surgical checklist at your hospital

Transfusion Medicine, EarlyView.
Abstract Objectives To highlight tranexamic acid (TXA) as ‘just one thing’ that every hospital could implement to reduce surgical bleeding and blood transfusions. Background TXA is a low‐cost antifibrinolytic agent that inhibits the breakdown of fibrin blood clots. Developed in Japan in the 1960s, it has been shown to reduce surgical bleeding.
Ian Roberts, Katharine Ker
wiley   +1 more source

Antifibrinolytic agents in traumatic haemorrhage. [PDF]

PLoS Medicine, 2005
Tim Coats, Beverly Hunt, Ian Roberts, Haleema Shakur   +3 more
doaj   +2 more sources