Tranexamic Acid; A Glittering Player in the Field of Trauma [PDF]
Bulletin of Emergency and Trauma, 2020 Trauma is still the leading cause of mortality and morbidity worldwide with an estimated 5.8 million mortalities every year [1] and approximately 60 million traumatic brain injuries (TBI) annually [2]. Hemorrhage remains the most common preventable cause
Fariborz Ghaffarpasand +4 more
doaj +1 more source
Postoperative Low-Dose Tranexamic Acid After Major Spine Surgery: A Matched Cohort Analysis [PDF]
Neurospine, 2020 Objective This was a retrospective, cohort study investigating the efficacy and safety of continuous low-dose postoperative tranexamic acid (PTXA) on drain output and transfusion requirements following adult spinal deformity surgery.
Lauren K. Dunn +13 more
doaj +1 more source
Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal
Periodontology 2000, EarlyView., 2023 Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra +3 more
wiley +1 more source
The Effect of Tranexamic Acid (Cyclokapron) on Post–Surgical Bleeding Following the Removal of Impacted Lower Wisdom Teeth in Healthy Individuals [PDF]
Al-Rafidain Dental Journal, 2008 Aims: To evaluate the effect of local irrigation with tranexamic acid in minimizing post–operative bleeding following the removal of impacted lower wisdom teeth.
Rayan S. Hamid +2 more
doaj +1 more source
Tranexamic acid evidence and controversies: An illustrated review
Research and Practice in Thrombosis and Haemostasis, 2021 Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding, trauma, postpartum hemorrhage, traumatic brain injury, and surgical site ...
Nicole Relke +2 more
doaj +1 more source
Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study [PDF]
, 2007 Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Barić, Davor +7 more
core +1 more source
Efficacy and safety of antifibrinolytics in oncological surgery: a systematic review and meta-analysis [PDF]
Revista Brasileira de Anestesiologia, 2019 Background and objectives: The administration of antifibrinolytics has been shown to be effective in reducing blood loss and the need for transfusions in surgeries. However, few studies have evaluated these drugs in cancer surgery.
Aline Menezes Sampaio +7 more
doaj +3 more sources
Synthesis and Hemostatic Activity of New Amide Derivatives
Molecules, 2022 Eight dipeptides containing antifibrinolytic agents (tranexamic acid, aminocaproic acid, 4-(aminomethyl)benzoic acid, and glycine—natural amino acids) were synthesized in a three-step process with good or very good yields.
Lukasz Banach +9 more
doaj +1 more source
Preventing perioperative bleeding in patients with inherited bleeding disorders [PDF]
, 2017 Data sources: Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, a regularly updated database informed by trials identified within electronic databases including MEDLINE.
Beacher, Nicholas, Watterson, Colin
core +1 more source
Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor. [PDF]
PLoS ONE, 2012 Bee venom is a rich source of pharmacologically active substances. In this study, we identified a bumblebee (Bombus ignitus) venom Kunitz-type serine protease inhibitor (Bi-KTI) that acts as a plasmin inhibitor.
Young Moo Choo +7 more
doaj +1 more source