Results 1 to 10 of about 75,167 (214)
TH Open, 2021 Background Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation.
Ton Lisman +3 more
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The Journal of Thoracic and Cardiovascular Surgery, 2012 In 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to decrease postoperative bleeding and complications.
DeAnda, Abe, Spiess, Bruce D.
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npj Regenerative Medicine, 2022 The biomaterial fibrin is widely used as a clinical tissue sealant in surgery. In preclinical research, fibrin is also extensively studied as a carrier material for growth factor delivery.
Jialu Liu +4 more
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Inhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo
Scientific Reports, 2021 Influenza viruses cause significant morbidity and mortality worldwide. Long-term or frequent use of approved anti-influenza agents has resulted in drug-resistant strains, thereby necessitating the discovery of new drugs. In this study, we found aprotinin,
Eun-Jung Song +8 more
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Aprotinin Inhibits SARS-CoV-2 Replication
Cells, 2020 Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S ...
Denisa Bojkova +13 more
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Frontiers in Bioengineering and Biotechnology, 2022 In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated.
Elea Boucard +5 more
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European Journal of Anaesthesiology, 2015 info:eu-repo/semantics ...
De Hert, Stefan +10 more
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The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. [PDF]
PLoS ONE, 2015 Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is ...
Chih-Yuan Lin +6 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThere is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many
Umberto Benedetto +7 more
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Role of Aprotinin in Moderate and Severe Burns
Indian Journal of Plastic Surgery, 1987 The role of Aprotinin (Antagosan) in moderate and severe thermal burns has been studied. Patients were randomized in two groups; both receiving same treatment with the exception that patients in trial group received Aprotinin in addition. 2000,000 K.I.U.
Prateek Bhatnagar +2 more
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