Results 1 to 10 of about 72,014 (117)

Aprotinin in high-risk isolated coronary artery bypass graft patients: a 3-year propensity matched study [PDF]

Journal of Cardiothoracic Surgery
Background Aprotinin, a serine protease inhibitor, has been used variably in cardiac surgery amidst ongoing debates about its safety following several previous studies.
Rishab Makam, Ayush Balaji, Marwan Al Munaer, Shantanu Bajaj, Nabil Hussein, Mahmoud Loubani   +5 more
doaj   +2 more sources

Proteomic insights into aprotinin’s immunomodulatory effects in attenuating renal fibrosis in a unilateral ureteral obstruction model [PDF]

Frontiers in Immunology
BackgroundChronic kidney disease involves progressive fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent renal effects, but its role in obstructive nephropathy is unclear.MethodsA unilateral
Xinyu Wang, Xinyu Wang, Ying Shen, Ying Shen, Danlei Chen, Danlei Chen, Lele Ding, Yuanlong Ding, Peilin Gan, Qian Long, Lu Song, Lu Song, Yaling Li, Xin Tian, Jun Zhang, Jian Xu, Jian Xu, Yutaka Kakizoe, Shu Yang, Fucheng Luo, Qinyuan Deng, Qinyuan Deng   +21 more
doaj   +2 more sources

Aprotinin Inhibits Thrombin Generation by Inhibition of the Intrinsic Pathway, but is not a Direct Thrombin Inhibitor

TH Open, 2021
Background Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation.
Ton Lisman, Jelle Adelmeijer, Dana Huskens, Joost C. M. Meijers   +3 more
doaj   +1 more source

Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

npj Regenerative Medicine, 2022
The biomaterial fibrin is widely used as a clinical tissue sealant in surgery. In preclinical research, fibrin is also extensively studied as a carrier material for growth factor delivery.
Jialu Liu, Ani Solanki, Michael J. V. White, Jeffrey A. Hubbell, Priscilla S. Briquez   +4 more
doaj   +1 more source

Inhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo

Scientific Reports, 2021
Influenza viruses cause significant morbidity and mortality worldwide. Long-term or frequent use of approved anti-influenza agents has resulted in drug-resistant strains, thereby necessitating the discovery of new drugs. In this study, we found aprotinin,
Eun-Jung Song, Erica Españo, Sang-Mu Shim, Jeong-Hyun Nam, Jiyeon Kim, Kiho Lee, Song-Kyu Park, Chong-Kil Lee, Jeong-Ki Kim   +8 more
doaj   +1 more source

Aprotinin Inhibits SARS-CoV-2 Replication

Cells, 2020
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S ...
Denisa Bojkova, Marco Bechtel, Katie-May McLaughlin, Jake E. McGreig, Kevin Klann, Carla Bellinghausen, Gernot Rohde, Danny Jonigk, Peter Braubach, Sandra Ciesek, Christian Münch, Mark N. Wass, Martin Michaelis, Jindrich Cinatl   +13 more
doaj   +1 more source

The degradation of gelatin/alginate/fibrin hydrogels is cell type dependent and can be modulated by targeting fibrinolysis

Frontiers in Bioengineering and Biotechnology, 2022
In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated.
Elea Boucard, Luciano Vidal, Flora Coulon, Carlos Mota, Jean-Yves Hascoët, Franck Halary   +5 more
doaj   +1 more source

The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. [PDF]

PLoS ONE, 2015
Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is ...
Chih-Yuan Lin, Jeffery H Shuhaiber, Hugo Loyola, Hua Liu, Pedro Del Nido, James A DiNardo, Frank A Pigula   +6 more
doaj   +1 more source

Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThere is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many
Umberto Benedetto, Douglas G. Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Gianni D. Angelini, Marcus Flather, David P. Taggart   +7 more
doaj   +1 more source

Role of Aprotinin in Moderate and Severe Burns

Indian Journal of Plastic Surgery, 1987
The role of Aprotinin (Antagosan) in moderate and severe thermal burns has been studied. Patients were randomized in two groups; both receiving same treatment with the exception that patients in trial group received Aprotinin in addition. 2000,000 K.I.U.
Prateek Bhatnagar, A. K. Singh, Tarachand Tarachand   +2 more
doaj   +1 more source