Results 11 to 20 of about 74,076 (196)

The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. [PDF]

PLoS ONE, 2015
Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is ...
Chih-Yuan Lin, Jeffery H Shuhaiber, Hugo Loyola, Hua Liu, Pedro Del Nido, James A DiNardo, Frank A Pigula   +6 more
doaj   +1 more source

Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThere is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many
Umberto Benedetto, Douglas G. Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Gianni D. Angelini, Marcus Flather, David P. Taggart   +7 more
doaj   +1 more source

Intraoperative anaphylaxis due to aprotinin after local application of fibrin sealant diagnosed by skin tests and basophil activation tests: a case report

JA Clinical Reports, 2021
Background There are few cases of anaphylaxis after local application of fibrin sealant diagnosed by skin tests. Case presentation A 49-year-old woman underwent partial lung resection under general anesthesia. Anesthesia was induced uneventfully. Shortly
Masaki Orihara, Tomonori Takazawa, Tatsuo Horiuchi, Shinya Sakamoto, Mutsumi Uchiyama, Shigeru Saito   +5 more
doaj   +1 more source

Role of Aprotinin in Moderate and Severe Burns

Indian Journal of Plastic Surgery, 1987
The role of Aprotinin (Antagosan) in moderate and severe thermal burns has been studied. Patients were randomized in two groups; both receiving same treatment with the exception that patients in trial group received Aprotinin in addition. 2000,000 K.I.U.
Prateek Bhatnagar, A. K. Singh, Tarachand Tarachand   +2 more
doaj   +1 more source

Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

Intensive Care Medicine Experimental, 2021
Background Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances.
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom   +11 more
doaj   +1 more source

Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

BMC Cardiovascular Disorders, 2005
Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J, Moxey Annette J, Carless Paul A, Henry David A   +3 more
doaj   +1 more source

Effect of Aprotinin and Avifavir^® Combination Therapy for Moderate COVID-19 Patients

Viruses, 2021
COVID-19 is a contagious multisystem inflammatory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We studied the efficacy of Aprotinin (nonspecific serine proteases inhibitor) in combination with Avifavir® or ...
Andrey A. Ivashchenko, Valeria N. Azarova, Alina N. Egorova, Ruben N. Karapetian, Dmitry V. Kravchenko, Natalia V. Krivonos, Vladimir G. Loginov, Stanislav V. Poyarkov, Elena A. Merkulova, Olga S. Rosinkova, Nikolay P. Savchuk, Mikhail A. Topr, Elena N. Simakina, Elena V. Yakubova, Alexandre V. Ivachtchenko   +14 more
doaj   +1 more source

Impact of aprotinin and renal function on mortality: a retrospective single center analysis

Journal of Cardiothoracic Surgery, 2011
Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing
Von Visger Jon, O'Brien William, Abdel-Rasoul Mahmoud, Yu Lianbo, Gulati Parul, Schloss Brian, Awad Hamdy   +6 more
doaj   +1 more source

Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, J. C., Kohl, Jacek, M. Jochum, E. Fink, B. Spies, M. Siebeck, M. Spannagl, Siebeck, Matthias, J. C. Cheronis, Cheronis, John C., J. Kohl, H. Fritz, Spannagl, Michael, Jochum, Marianne, Spies, Bernd, Fritz, Hans, Fink, Edwin   +16 more
core   +1 more source

Modulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study

Research and Practice in Thrombosis and Haemostasis, 2022
Background Thromboinflammation plays a central role in severe COVID‐19. The kallikrein pathway activates both inflammatory pathways and contact‐mediated coagulation.
Matthias M. Engelen, Quentin Van Thillo, Albrecht Betrains, Iwein Gyselinck, Caroline P. Martens, Valérie Spalart, Anna Ockerman, Caroline Devooght, Joost Wauters, Jan Gunst, Carine Wouters, Christophe Vandenbriele, Steffen Rex, Laurens Liesenborghs, Alexander Wilmer, Philippe Meersseman, Greet Van den Berghe, Dieter Dauwe, Ann Belmans, Michiel Thomeer, Tom Fivez, Dieter Mesotten, David Ruttens, Luc Heytens, Ilse Dapper, Sebastiaan Tuyls, Brecht De Tavernier, Peter Verhamme, Thomas Vanassche, DAWn Consortium Members   +29 more
doaj   +1 more source