Results 11 to 20 of about 72,103 (188)

Aprotinin revisited [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2012
In 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to decrease postoperative bleeding and complications.
DeAnda, Abe, Spiess, Bruce D.
openaire   +2 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Aprotinin

European Journal of Anaesthesiology, 2015
info:eu-repo/semantics ...
De Hert, Stefan, Van Der Linden, Philippe, Von Heymann, Christian, Gill, Ravi, Habre, Walid, Lancé, Marcus, Llau, Juan J.V., Meier, Jens, Pouard, Philippe, Samama, Charles Marc, Van Der Linden, Jan   +10 more
openaire   +6 more sources

Intraoperative anaphylaxis due to aprotinin after local application of fibrin sealant diagnosed by skin tests and basophil activation tests: a case report

JA Clinical Reports, 2021
Background There are few cases of anaphylaxis after local application of fibrin sealant diagnosed by skin tests. Case presentation A 49-year-old woman underwent partial lung resection under general anesthesia. Anesthesia was induced uneventfully. Shortly
Masaki Orihara, Tomonori Takazawa, Tatsuo Horiuchi, Shinya Sakamoto, Mutsumi Uchiyama, Shigeru Saito   +5 more
doaj   +1 more source

APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS

Zagazig Journal of Pharmaceutical Sciences, 1997
The effect of the Kallikrein inhibitor, aprotinin, on hydrochlorothiazide and furosemide inducing pancreatitis has been studied in male rats. Treatment of animals with hydrochlorothiazide and furosemide for two weeks significantly increased serum lipase,
Hoda Mohamed , Hazar Yacoub , Salwa El-Melegy , Nadia Gouda   +3 more
doaj   +1 more source

Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

BMC Cardiovascular Disorders, 2005
Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J, Moxey Annette J, Carless Paul A, Henry David A   +3 more
doaj   +1 more source

Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

Intensive Care Medicine Experimental, 2021
Background Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances.
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom   +11 more
doaj   +1 more source

Effect of Aprotinin and Avifavir^® Combination Therapy for Moderate COVID-19 Patients

Viruses, 2021
COVID-19 is a contagious multisystem inflammatory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We studied the efficacy of Aprotinin (nonspecific serine proteases inhibitor) in combination with Avifavir® or ...
Andrey A. Ivashchenko, Valeria N. Azarova, Alina N. Egorova, Ruben N. Karapetian, Dmitry V. Kravchenko, Natalia V. Krivonos, Vladimir G. Loginov, Stanislav V. Poyarkov, Elena A. Merkulova, Olga S. Rosinkova, Nikolay P. Savchuk, Mikhail A. Topr, Elena N. Simakina, Elena V. Yakubova, Alexandre V. Ivachtchenko   +14 more
doaj   +1 more source

Impact of aprotinin and renal function on mortality: a retrospective single center analysis

Journal of Cardiothoracic Surgery, 2011
Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing
Von Visger Jon, O'Brien William, Abdel-Rasoul Mahmoud, Yu Lianbo, Gulati Parul, Schloss Brian, Awad Hamdy   +6 more
doaj   +1 more source

Influence of ultra-low dose Aprotinin on thoracic surgical operations: a prospective randomized trial

Journal of Cardiothoracic Surgery, 2008
Background The blood saving effect of aprotinin has been well documented in cardiac surgery. In thoracic surgery, very few recent studies, using rather high doses of aprotinin, have shown a similar result.
Sourgiadaki Efrosini, Stamou-Kouki Helen, Crockett James, Koletsis Efstratios N, Panagopoulos Nikolaos, Apostolakis Efstratios, Filos Kriton, Dougenis Dimitrios   +7 more
doaj   +1 more source