Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial) [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThere is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many
Umberto Benedetto +7 more
doaj +10 more sources
Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients. [PDF]
PLoS ONE, 2013 BackgroundTo compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.Methods and findingsWe ...
Patrick Meybohm +3 more
doaj +5 more sources
Inhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo
Scientific Reports, 2021 Influenza viruses cause significant morbidity and mortality worldwide. Long-term or frequent use of approved anti-influenza agents has resulted in drug-resistant strains, thereby necessitating the discovery of new drugs. In this study, we found aprotinin,
Eun-Jung Song +8 more
doaj +2 more sources
Aprotinin Inhibits SARS-CoV-2 Replication
Cells, 2020 Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S ...
Denisa Bojkova +13 more
doaj +2 more sources
Aprotinin in high-risk isolated coronary artery bypass graft patients: a 3-year propensity matched study [PDF]
Journal of Cardiothoracic SurgeryBackground Aprotinin, a serine protease inhibitor, has been used variably in cardiac surgery amidst ongoing debates about its safety following several previous studies.
Rishab Makam +5 more
doaj +2 more sources
Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpórea Assessment of aprotinin in the reduction of inflammatory systemic response in children undergoing surgery with cardiopulmonary bypass [PDF]
Brazilian Journal of Cardiovascular Surgery, 2010 OBJETIVO: Avaliar se a aprotinina em altas doses hemostáticas pode reduzir o processo inflamatório após circulação extracorpórea (CEC) em crianças. MÉTODOS: Estudo prospectivo randomizado em crianças de 30 dias a 4 anos de idade, submetidas à correção de
Cesar Augusto Ferreira +7 more
doaj +4 more sources
III. Aprotinin and cardiac surgery: a sorry tale of evidence misused. [PDF]
British Journal of Anaesthesia, 2013 V. McMullan, R. P. Alston
semanticscholar +2 more sources
A Comparison of Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery
New England Journal of Medicine, 2008 Dean A Fergusson +2 more
exaly +2 more sources
Replacement of aprotinin by ε-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome. [PDF]
British Journal of Anaesthesia, 2013 K. Martin +8 more
semanticscholar +2 more sources
The Risk Associated with Aprotinin in Cardiac Surgery
New England Journal of Medicine, 2006 D. Mangano, I. C. Tudor, Cynthia Dietzel
exaly +2 more sources