Results 11 to 20 of about 75,167 (214)

Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients. [PDF]

PLoS ONE, 2013
BackgroundTo compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.Methods and findingsWe ...
Patrick Meybohm, Eva Herrmann, Julia Nierhoff, Kai Zacharowski   +3 more
doaj   +2 more sources

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. [PDF]

PLoS ONE, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Christoph A Reichel, Max Lerchenberger, Bernd Uhl, Markus Rehberg, Nina Berberich, Stefan Zahler, Matthias P Wymann, Fritz Krombach   +7 more
doaj   +3 more sources

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke. [PDF]

Ann Neurol
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Solo Nomenjanahary M, Desilles JP, Zemali F, Perrot A, Di Meglio L, Zalghout S, Fasille J, Neel J, Loyau S, Labreuche J, Bourrienne MC, Faille D, Delvoye F, Ollivier V, Dupont S, Rogozarski J, Brikci-Nigassa N, Medcalf RL, Ajzenberg N, Mazighi M, Ho-Tin-Noé B, compoCLOT Study Group.   +21 more
europepmc   +2 more sources

Proteomic insights into aprotinin’s immunomodulatory effects in attenuating renal fibrosis in a unilateral ureteral obstruction model [PDF]

Frontiers in Immunology
BackgroundChronic kidney disease involves progressive fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent renal effects, but its role in obstructive nephropathy is unclear.MethodsA unilateral
Xinyu Wang, Xinyu Wang, Ying Shen, Ying Shen, Danlei Chen, Danlei Chen, Lele Ding, Yuanlong Ding, Peilin Gan, Qian Long, Lu Song, Lu Song, Yaling Li, Xin Tian, Jun Zhang, Jian Xu, Jian Xu, Yutaka Kakizoe, Shu Yang, Fucheng Luo, Qinyuan Deng, Qinyuan Deng   +21 more
doaj   +2 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS

Zagazig Journal of Pharmaceutical Sciences, 1997
The effect of the Kallikrein inhibitor, aprotinin, on hydrochlorothiazide and furosemide inducing pancreatitis has been studied in male rats. Treatment of animals with hydrochlorothiazide and furosemide for two weeks significantly increased serum lipase,
Hoda Mohamed , Hazar Yacoub , Salwa El-Melegy , Nadia Gouda   +3 more
doaj   +1 more source

Intraoperative anaphylaxis due to aprotinin after local application of fibrin sealant diagnosed by skin tests and basophil activation tests: a case report

JA Clinical Reports, 2021
Background There are few cases of anaphylaxis after local application of fibrin sealant diagnosed by skin tests. Case presentation A 49-year-old woman underwent partial lung resection under general anesthesia. Anesthesia was induced uneventfully. Shortly
Masaki Orihara, Tomonori Takazawa, Tatsuo Horiuchi, Shinya Sakamoto, Mutsumi Uchiyama, Shigeru Saito   +5 more
doaj   +1 more source

Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in open-heart surgery [PDF]

, 1990
Intraoperative administration of the proteinase Inhibitor aprotinin causes reduction in blood loss and homologous blood requirement in patients undergoing cardiac surgery.
Dietrich, W., Sebening, F., Wendt, P., Spannagl, Michael, Baranky, A., Jochum, Marianne, Schramm, Wolfgang   +6 more
core   +1 more source

Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

BMC Cardiovascular Disorders, 2005
Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J, Moxey Annette J, Carless Paul A, Henry David A   +3 more
doaj   +1 more source

Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

Intensive Care Medicine Experimental, 2021
Background Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances.
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom   +11 more
doaj   +1 more source