Results 21 to 30 of about 74,076 (196)

Influence of ultra-low dose Aprotinin on thoracic surgical operations: a prospective randomized trial

Journal of Cardiothoracic Surgery, 2008
Background The blood saving effect of aprotinin has been well documented in cardiac surgery. In thoracic surgery, very few recent studies, using rather high doses of aprotinin, have shown a similar result.
Sourgiadaki Efrosini, Stamou-Kouki Helen, Crockett James, Koletsis Efstratios N, Panagopoulos Nikolaos, Apostolakis Efstratios, Filos Kriton, Dougenis Dimitrios   +7 more
doaj   +1 more source

The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2

Molecules, 2022
The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19.
Andrey A. Ivashchenko, Bogdan A. Zagribelnyy, Yan A. Ivanenkov, Ilya A. Ivashchenko, Ruben N. Karapetian, Dmitry V. Kravchenko, Nikolay P. Savchuk, Elena V. Yakubova, Alexandre V. Ivachtchenko   +8 more
doaj   +1 more source

The possibilities of using the inhibitors of matrix metalloproteinases for keratoplasty

Трансплантология (Москва), 2023
Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using ...
K. V. Sirotkina, E. V. Chentsova
doaj   +1 more source

Aprotinin and classic wound drainage are unnecessary in total hip replacement a prospective randomized trial

European Journal of Medical Research, 2011
Background Classic wound drainage is still common in hip replacement but its benefit is doubtful. The role of systemic administration of proteinase inhibitors like aprotinin to avoid perioperative blood loss is still unclear.
Fleischmann F, Matuschek C, Orth K, Gerber PA, Mota R, Knoefel WT, Peiper M, Schick M, van Griensven M, Bdlke E, Fleischmann W   +10 more
doaj   +1 more source

Antifibrinolytics and cardiac surgery: The past, the present, and the future

Annals of Cardiac Anaesthesia, 2020
Cardiac surgery is usually associated with significant blood loss, which often necessitates blood transfusion. In order to decrease the risks associated with the latter, pharmacological as well as nonpharmacological strategies have been used to reduce ...
Naresh K Aggarwal, Arun Subramanian
doaj   +1 more source

Antifibrinolytics in cardiac surgery

Annals of Cardiac Anaesthesia, 2013
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Achal Dhir
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Different aprotinin applications influencing hemostatic chances in orthotopic liver transplantation [PDF]

, 1992
The effect of different aprotinin applications on hemmtatic changes and blood product requirements in orthotopic liver transplantation was investigated in a prospective, open, and randomized study.
Bechstein, W. O., Muser, M., Neuhaus, P., Himmelreich, G., Jochum, Marianne, Riess, H., Slama, K.-J.   +6 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in open-heart surgery [PDF]

, 1990
Intraoperative administration of the proteinase Inhibitor aprotinin causes reduction in blood loss and homologous blood requirement in patients undergoing cardiac surgery.
Dietrich, W., Sebening, F., Wendt, P., Spannagl, Michael, Baranky, A., Jochum, Marianne, Schramm, Wolfgang   +6 more
core