Results 21 to 30 of about 114,163 (306)

Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin. [PDF]

Journal of Thoracic and Cardiovascular Surgery, 2013
N. Howell, E. Senanayake, N. Freemantle, D. Pagano   +3 more
semanticscholar   +2 more sources

Aprotinin during Coronary-Artery Bypass Grafting and Risk of Death

New England Journal of Medicine, 2008
Sebastian Schneeweiss, Alexander Muir Walker   +1 more
exaly   +2 more sources

Aprotinin Inhibits Thrombin Generation by Inhibition of the Intrinsic Pathway, but is not a Direct Thrombin Inhibitor

TH Open, 2021
Background Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation.
Ton Lisman, Jelle Adelmeijer, Dana Huskens, Joost C. M. Meijers   +3 more
doaj   +1 more source

Aprotinin treatment against SARS‐CoV‐2: A randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19

European Journal of Clinical Investigation, 2022
SARS‐CoV‐2 virus requires host proteases to cleave its spike protein to bind to its ACE2 target through a two‐step furin‐mediated entry mechanism. Aprotinin is a broad‐spectrum protease inhibitor that has been employed as antiviral drug for other human ...
F. J. Redondo‐Calvo, J. Padín, J. Muñoz‐Rodríguez, Leticia Serrano‐Oviedo, Pilar López‐Juárez, M. P. Porras Leal, F. G. González Gasca, M. Rodriguez Martínez, Raúl Pérez Serrano, Abraham Sánchez Cadena, Natalia Bejarano‐Ramírez, Constanza Muñoz Hornero, J. B. Barberá Farré, I. Domínguez-Quesada, M. A. Sepúlveda Berrocal, María Dolores Villegas Fernández‐Infantes, María Isabel Manrique Romo, Ángel Parra Comino, J. M. Pérez‐Ortiz, F. J. Gómez‐Romero, AM T I P A R A C I N N A V R J P R G MS J García Pérez Palomino Muñoz Espinosa Justo Ventura, A. García Pérez, T. Palomino Muñoz, I. Espinosa Justo, P. Ventura López, A. Cosmen‐Sánchez, R. Martínez Manzanal, A. Asenjo Villamayor, C. Loras Gallego, I. Alcañiz Octavio, N. Palma Bermejo, N. Andrés Navarro, A. Lizcaino Lizcanino, V. Cano Llorente, R. De Prado Narciso, J. Hoyos Mohedano, P. Moya Gómez, R. Bodoque-Villar, G. Pulido‐Sánchez, M. I. Illescas Fernández‐Bermejo, J. Martínez Alarcón   +40 more
semanticscholar   +1 more source

Aprotinin revisited [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2012
In 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to decrease postoperative bleeding and complications.
DeAnda, Abe, Spiess, Bruce D.
openaire   +2 more sources

Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

npj Regenerative Medicine, 2022
The biomaterial fibrin is widely used as a clinical tissue sealant in surgery. In preclinical research, fibrin is also extensively studied as a carrier material for growth factor delivery.
Jialu Liu, Ani Solanki, Michael J. V. White, Jeffrey A. Hubbell, Priscilla S. Briquez   +4 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

The degradation of gelatin/alginate/fibrin hydrogels is cell type dependent and can be modulated by targeting fibrinolysis

Frontiers in Bioengineering and Biotechnology, 2022
In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated.
Elea Boucard, Luciano Vidal, Flora Coulon, Carlos Mota, Jean-Yves Hascoët, Franck Halary   +5 more
doaj   +1 more source

The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. [PDF]

PLoS ONE, 2015
Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is ...
Chih-Yuan Lin, Jeffery H Shuhaiber, Hugo Loyola, Hua Liu, Pedro Del Nido, James A DiNardo, Frank A Pigula   +6 more
doaj   +1 more source

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources