Results 21 to 30 of about 5,378 (170)

COMPARISON OF HEMOSTASIS WITH TRANEXAMIC ACID IN TOTAL KNEE ARTHROPLASTY

Acta Ortopédica Brasileira, 2021
Objective: To compare the use of intravenous and topical tranexamic acid (TXA) in unilateral primary total knee arthroplasty (TKA) in relation to blood loss and complications inherent to the medication.
OTÁVIO MONTOVANELLI MONTEIRO, RODRIGO TURRA PERRONE, FABRÍCIO NASCIMENTO ALMEIDA, CID PEREIRA DE MOURA JUNIOR, SAULO GOMES DE OLIVEIRA, GUSTAVO DALLA BERNARDINA DE ALMEIDA   +5 more
doaj   +1 more source

Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT

Health Technology Assessment, 2021
Background: Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death.
Ian Roberts, Haleema Shakur-Still, Amy Aeron-Thomas, Danielle Beaumont, Antonio Belli, Amy Brenner, Madeleine Cargill, Rizwana Chaudhri, Nicolas Douglas, Lauren Frimley, Catherine Gilliam, Amber Geer, Zahra Jamal, Rashid Jooma, Raoul Mansukhani, Alec Miners, Jason Pott, Danielle Prowse, Temitayo Shokunbi, Jack Williams   +19 more
doaj   +1 more source

Plasmin Inhibitor in Health and Diabetes: Role of the Protein as a Therapeutic Target

TH Open, 2022
The vascular obstructive thrombus is composed of a mesh of fibrin fibers with blood cells trapped in these networks. Enhanced fibrin clot formation and/or suppression of fibrinolysis are associated with an increased risk of vascular occlusive events ...
Basmah Alsayejh, Noppadol Kietsiriroje, Mansour Almutairi, Katie Simmons, Nikoletta Pechlivani, Sreenivasan Ponnambalam, Ramzi A. Ajjan   +6 more
doaj   +1 more source

Minimal Dose of Tranexamic Acid Is Effective in Reducing Blood Loss in Complex Spine Surgeries: A Randomized Double-Blind Placebo Controlled Study [PDF]

Asian Spine Journal, 2018
Study Design A randomized double-blind placebo controlled study. Purpose In the present study, we aimed to assess the efficacy of tranexamic acid (TXA) in reducing blood loss after laminectomy and posterolateral fusion of the spine.
Moslem Shakeri, Firooz Salehpour, Ghaffar Shokouhi, Kamkar Aeinfar, Javad Aghazadeh, Farhad Mirzaei, Seyed Ahmad Naseri Alavi   +6 more
doaj   +1 more source

Coagulation and Bleeding Management in Pediatric Extracorporeal Membrane Oxygenation: Clinical Scenarios and Review

Frontiers in Medicine, 2019
Extracorporeal membrane oxygenation (ECMO) is a life-saving procedure that requires careful coagulation management. Indications for ECMO continue to expand, leading to more complicated patients treated by ECMO teams.
Lisa A. Hensch, Lisa A. Hensch, Shiu-Ki Rocky Hui, Shiu-Ki Rocky Hui, Jun Teruya, Jun Teruya   +5 more
doaj   +1 more source

Evolving perspectives on blood transfusion in obstetric hemorrhage: a narrative review [PDF]

Korean Journal of Anesthesiology
Globally, postpartum hemorrhage is still among the most significant factors in preventable maternal morbidity and mortality. Although early recognition and intervention have improved with advances in obstetric care, transfusion practices are often based ...
Yoon Ji Choi, Sang Hun Kim
doaj   +1 more source

Assessing policy and operational barriers to tranexamic acid utilization in treating postpartum hemorrhage in Kano, Lagos, and Niger states

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study explores the barriers to the use of tranexamic acid (TXA) for the management of postpartum hemorrhage (PPH) and provides recommendations to improve its use. Methods We conducted a mixed‐methods assessment involving 229 healthcare professionals in Kano, Lagos, and Niger States of Nigeria.
Chukwunonso Nwaokorie, Aisha Abdullahi, Naanma Kangkum, Valentine Amasiatu, Eric Aigbogun, Uchenna Igbokwe   +5 more
wiley   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, EarlyView.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

The use of fibrinolysis inhibitors in cardiac surgery with cardiopulmonary bypass (literature review)

Вестник анестезиологии и реаниматологии
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva, K. N. Khrapov, A. A. Khryapa, K. Yu. Kankova   +3 more
doaj   +1 more source