Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients [PDF]
, 2013 Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Herrmann, Eva +3 more
core +3 more sources
Disseminated intravascular and intracardiac thrombosis after cardiopulmonary bypass
Journal of Anaesthesiology Clinical Pharmacology, 2017 Massive intracardiac and intravascular thrombosis is a rare complication following cardiopulmonary bypass (CPB). Most of the cases of the disseminated thrombosis have been reported in patients undergoing complex cardiac surgeries and those receiving ...
Deepak K Tempe +4 more
doaj +1 more source
Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects. [PDF]
, 2017 Intracerebral hemorrhages (ICH) represent about 10-15% of all strokes per year in the United States alone. Key variables influencing the long-term outcome after ICH are hematoma size and growth.
Lim-Hing, Krista, Rincon, Fred
core +2 more sources
Anti-fibrinolytic agents in post partum haemorrhage: a systematic review
BMC Pregnancy and Childbirth, 2009 Background Post partum haemorrhage is a leading cause of maternal death worldwide. It also contributes to maternal morbidity as women may require a hysterectomy to control bleeding, or may require a blood transfusion, which can transmit viral infections.
Blackhall Karen +4 more
doaj +1 more source
Perioperative hyperfibrinolysis – physiology and pathophysiology
Brazilian Journal of Anesthesiology, 2021 Introduction and objectives: The role of the anesthesiologist in the perioperative management of hemostasis has attracted increasing attention. The fibrinolytic system participates in hemostasis, removing clots after repair of the vascular injury.
David Silveira Marinho
doaj +1 more source
COMPARISON OF HEMOSTASIS WITH TRANEXAMIC ACID IN TOTAL KNEE ARTHROPLASTY
Acta Ortopédica Brasileira, 2021 Objective: To compare the use of intravenous and topical tranexamic acid (TXA) in unilateral primary total knee arthroplasty (TKA) in relation to blood loss and complications inherent to the medication.
OTÁVIO MONTOVANELLI MONTEIRO +5 more
doaj +1 more source
Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions [PDF]
, 2014 Objectives: Patients with inherited bleeding disorders are at high risk of bleeding following oral surgery and present challenges to the oral surgeons. Aim of this study was to report our experience in dental extraction in patients exhibiting Haemophilia
Peisker, Andre +2 more
core +1 more source
Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]
, 2008 Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C. +9 more
core +2 more sources
Effect of oral tranexamic acid on macular edema associated with retinal vein occlusion or diabetes [PDF]
, 2017 Purpose: Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can also cause a decrease in vascular permeability. We hypothesized that TXA could improve macular edema (ME) that is caused by an increase in retinal vascular permeability.
Gosho Masahiko +7 more
core +3 more sources
Health Technology Assessment, 2021 Background: Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death.
Ian Roberts +19 more
doaj +1 more source