Results 41 to 50 of about 5,590 (131)
Glanzmann thrombasthenia: genetic basis and clinical correlates
Haematologica, 2020
Glanzmann thrombasthenia (GT) is an autosomal recessive disorder of platelet aggregation caused by quantitative or qualitative defects in integrins αIIb and β3. These integrins are encoded by the ITGA2B and ITGB3 genes and form platelet glycoprotein (GP)Juliana Perez Botero, Kristy Lee, Brian R Branchford, Paul F Bray, Kathleen Freson, Michele P. Lambert, Minjie Luo, Shruthi Mohan, Justyne E. Ross, Wolfgang Bergmeier, Jorge Di Paola +10 moredoaj +1 more sourceInter‐institutional perspectives on usage of fibrinogen replacement therapies in North America
Vox Sanguinis, EarlyView.Abstract Background and Objectives
Cryoprecipitated antihemophilic factor (cryoprecipitate), fibrinogen concentrate (FC), and pathogen‐reduced cryoprecipitated fibrinogen complex (PR cryoprecipitate) are sources of fibrinogen replacement, and each has advantages and disadvantages in terms of cost, efficacy, safety, and logistics of administration. This Cindy Tay, Laura K. Dilly, Wen Lu, Kerry O'Brien, Hlaing Tint, Quentin Eichbaum +5 morewiley +1 more sourceSystemic Bevacizumab for Severe Bleeding From Acquired Gastrointestinal Vascular Malformations
American Journal of Hematology, Volume 101, Issue 10, Page 2605-2615, October 2026.Targeted antiangiogenic therapy with systemic bevacizumab for bleeding from acquired GI VMs was found to be safe and effective for chronic and severe bleeding from acquired vascular malformations due to idiopathic angiodysplasia, chronic liver disease, and deficiencies of von Willebrand factor, in a patient population comprised mostly of heavily ...Nardeen E. Ayad, Jacob R. Anderson, Bimalangshu Dey, Rebecca Karp Leaf, Andrew B. Song, Hanny Al‐Samkari +5 morewiley +1 more sourceAcute Hemorrhagic Manifestations in a Pregnant Patient With Type 1 von Willebrand Disease: Challenges in Management of Bleeding Disorders During Gestation
Clinical Case Reports, Volume 14, Issue 10, October 2026.ABSTRACT
This case reports a primigravida with Type 1 von Willebrand disease experiencing hematuria and gingival bleeding despite prophylaxis. Although pregnancy raises factor levels, her response was insufficient. Desmopressin successfully controlled mucosal hemorrhage, avoiding antifibrinolytics due to obstructive risk.Jose Luis Rojas‐Oviedo, María Fernanda Leal Walteros, Dauris Lineth Mejía Pérez, Jorge Eliecer Castellanos Corredor, Danna Geraldinne Amaya Sánchez, Ana Sofía Lancheros Ramírez +5 morewiley +1 more sourceLung‐Cardiovascular Interactions and Derangements in ARDS
Comprehensive Physiology, Volume 16, Issue 5, October 2026.This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.Pablo A. Sanchez, Connor O'Brien, Matthieu Legrand, Carolyn S. Calfee, Michael A. Matthay +4 morewiley +1 more sourceMonitoring and feedback using data in transfusion medicine: A study of practices from the BEST Collaborative
Transfusion, Volume 66, Issue 10, Page 1939-1951, October 2026.Abstract Background
It is imperative that health systems monitor transfusion practice quality and implement improvements when evidence‐based practice gaps are identified. Despite the importance of data‐driven quality activities, little is known about approaches employed by hospitals. This study aimed to describe strategies used by hospitals to acquire, Ryan A. Metcalf, Allison Mo, Sandra K. White, Gustavo C. Duarte, Nancy M. Dunbar, Katie Hands, Anil K. Panigrahi, Jessica L. Poisson, Nabiha H. Saifee, Hua Shan, Erica M. Wood, Michael F. Murphy, Simon J. Stanworth +12 morewiley +1 more sourceThe usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients
Thrombosis Journal, 2023 Background Tranexamic acid (TXA) is an antifibrinolytic drug that blocks lysine-binding sites on the profibrinolytic enzyme plasminogen. Aortic diseases with chronic consumption coagulopathy may lead to disseminated intravascular coagulation (DIC) and ...Naruko Suzuki, Nobuaki Suzuki, Yuka Kawaguchi, Shuichi Okamoto, Takeshi Kanematsu, Akira Katsumi, Atsuo Suzuki, Shogo Tamura, Tetsuhito Kojima, Hitoshi Kiyoi, Tadashi Matsushita +10 moredoaj +1 more sourceTransfusion intensity in the ICU: Reasons and triggers
Transfusion, Volume 66, Issue 10, Page 1963-1973, October 2026.Abstract Background
The reasons and physiological triggers for blood transfusion in critically ill patients are not well characterized. Beyond hemoglobin levels, hemodynamic instability is frequently cited, but its role across clinical contexts remains unclear.Merijn C. Reuland, Senta J. Raasveld, Jimmy Schenk, Claudia van den Oord, Sanne de Bruin, Caroline M. Schaap, Andrew W. J. Flint, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Thomas W. L. Scheeren, Tarikul Hamid, Michaël Piagnerelli, Tina Tomić Mahečić, Jan Benes, Lene Russell, Hernan Aguirre‐Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V. Llau, Manuel Quintana‐Diaz, Maria Cronhjort, Carmen A. Pfortmueller, Nihan Yapici, Nathan D. Nielsen, Akshay Shah, Harm‐Jan de Grooth, Zoe McQuilten, Cécile Aubron, Alexander P. J. Vlaar, Marcella C. A. Müller, InPUT Study Group, Alisa Higgins, Ary Serpa Neto, Karina Brady, Erica Wood, Alexis Poole, Tony Trapani, Meredith Young, Jamie Cooper, Paul Secombe, Graham Reece, Prashanti Marella, David Brewster, Alan Rashid, Ruwan Suwandarathne, Raman Azad, Jonathan Barrett, Elisha Turner, Amber‐Louise Poulter, Lixian Chen, Vishwanath Biradar, Christina Whitehead, Sandra Peake, Alexis Tabah, Stephanie O'Connor, Michael Reade, Guido Janssen, Richard McAllister, Katherine Triplett, David Bowen, Hergen Buscher, John Santamaria, Dinesh Parmar, Paul Power, Craig French, David Bowen, Matthew Mac Partlin, David Bowen, Injamam Ull Haque, Alain Roman, Višnja Ikic, Slavica Kvolik, Robert Bojčić, Kazimir Juričić, Martin Duksa, Lukáš Bílek, Igor Satinsky, Jan Zatloukal, Lene Russell, Morten H. Bestle, Christian S. Meyhoff, Ana Maria Diaz‐Medina, Verónica Llumiquinga, Hernán Aguirre‐Bermeo, Heinert Enmanuel Gonzabay‐Campos, Mohamed Elbahnasawy, Xavier Chapalain, Charlène Le Moal, Pierre‐Yves Egreteau, Yoann Launey, Florian Reizine, Florence Boissier, Reignier Jean, Stephan Ehrmann, Eddy Lebas, Gaelle Corno, Pauline Cailliez, Pierre Garçon, Guillaume Carteaux, Antoine Kimmoun, Johann Auchabie, Danai Theodoulou, Stavros Aloizos, Eleftherios Papadakis, Konstantinos Tsakalis, Giorgos Marinakis, Ioannis Georgakas, Paraskevi Tripolitsioti, Sofia Nikolakopoulou, Georgios Papathanakos, Evangelia Tsika, Ourania Mousafiri, Athanasios Prekates, Georgia Micha, Athina Lavrentieva, Theodoros Aslanidis, Athina Palaiologou, Clementine Bostantzoglou, Evangelia Dikoudi, Silia Karaouli, Sophia Pouriki, Swapna Vijayakumaran, Darshana Rathod, Venkat Raman Kola, Deepak Jeswani, Suparna Bharadwaj, Amol Hartalkar, Ata Mahmoodpoor, Marwah Abdulkhaleq, Mariachiara Ippolito, Antonella Cotoia, Marco Covotta, Sanfilippo Filippo, Ehab Ishteiwy, Hebtallah Benzarti, Ahmed Elmabri Mohammed Bouhuwaish, Alya Abdalhadi, Ahmad Buimsaedah, Eman Ali Abdulwahed, Khalil Tamoos, Eman Younes, Asma Abubakr Saleh Alkamkhe, Marwa Biala, Hajer Abdalla Mohammed Hwili, Najat Shaban Ben Hasan, Bushray Alhadi Almiqlash, Mawadda Altair, Rema Otman, Mohamed Fathi Al Gharyani, Omlez Mohammed Alkeelani, Hibah Bakeer, Azah Mukhtar Omar Affat, Husayn Aween, Aihab Benamwor, Mohamed Alsori, Najwa Abdelrahim, GHANNAM Abdelilah, Rachael Parke, Yan Chen, Jan Mehrtens, Pawel Twardowski, Ross Freebairn, Rima Song, Charles Gibson, Jonathan Chen, Richard Moore, Mary Rose Sol Cruz, Anna Wludarczyk, Łukasz Krzych, Marta Szczukocka, Marcin Kubiak, Maciej Molsa, Magdalena Wujtewicz, Agnieszka Wieczorek, Agnieszka Misiewska‐Kaczur, Dariusz Onichimowski, Jakub Mazur, Pawel Zatorski, Ana Marta Mota, Joana Fernandes, Diana Castro, Elisabete Coelho, Alexandra Paula, Teresa Guimarães, Diana Adrião, Igor Mark, Elizabeta Mušič, Tomislav Mirković, Andrej Markota, Natalija Krope, Marko Kmet, Petra Forjan, Tomaž Savli, Gerardo Aguilar, Rebeca González‐Celdrán, Estefanía Martínez‐González, Agustín Díaz, María José Colomina, Francisco Hidalgo, Carlos Ferrando, Raquel Ferrandis, Carolina Ferrer, Virginia Cegarra, Aurelio Gómez‐Luque, Stina Henman, Disa Blomstrand, Emelie Risberg, Natalie Johansen, Henrik Rajala, Natalie Layous, Eline A. Vlot, Michiel Erkamp, Nicole Juffermans, Claudia van den Oord, Jimmy Schenk, Merijn Reuland, Stefan van Wonderen, Caroline Schaap, Tessa. A. van der Meer, Lidija Kuznecova‐Keppel Hesselink, Victor van Bochove, Murat Acarel, Evren Senturk, Mahmut Alp Karahan, Aynur Camkiran Firat, Yahya Yildiz, Osman Ekinci, Asu Ozgultekin, Huseyin Arikan, Gamze Kucukosman, Bengu Gulhan Aydin, Mehmet Yavuz, Alev Oztas, Nilgun Kavrut Ozturk, Umut Sabri Kasapoglu, Hakan Miniksar, Eylem Tuncay, Cenk Indelen, Halide Ogus, Basar Erdivanli, Ayca Sultan Sahin, Mehmet Yilmaz, Erken Sayan, Canan Yilmaz, Senay Goksu, Betul Basaran, Emine Kutahya, Ayfer Kaya Gok, Ayse Ozcan, Iskender Kara, Seyfi Kartal, Kemal Tolga Saracoglu, Yeliz Bilir, Selin Eyupoglu, Nigar Ertugrul Oruc, Kubilay Issever, Jamie Patel, Jayson Clarke, Louise Ma, Tom Lawton, Brendan Sloan, Santhana Kannan, Richard Innes, Mark Carpenter, Luke Newey, Hazem Alwagih, Chris Acott, Anil Hormis, James Herdman, Osama Akrama, Rachel Baumber, Olena Khomenko, Akram Khan, Zubair Hasan, Jay S. Raval, Lauren Sutherland +286 morewiley +1 more sourcePersistent Gingival Bleeding After Scaling: A Diagnostic Clue to von Willebrand Disease
Clinical Case Reports, Volume 14, Issue 9, September 2026.ABSTRACT
Von Willebrand disease (VWD) is not a rare inherited bleeding disorder. However, it is frequently underdiagnosed because early mucocutaneous bleeding manifestations are often attributed to local factors such as inflammation or anatomical abnormalities, leading to delayed recognition of the underlying systemic disease. A 31‐year‐old Han Chinese Huihui Zhang, Nan Qiu, Zhengguo Cao, Shuhuan Shang +3 morewiley +1 more source
