Results 151 to 160 of about 206,382 (334)

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Vitamin K Antagonist Use and Fracture [PDF]

Journal of General Internal Medicine, 2019
Wallis C Y, Lau, Kenneth K C, Man, Ian C K, Wong   +2 more
openaire   +2 more sources

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Tecarfarin: A Novel Vitamin K Antagonist [PDF]

Thrombosis and Haemostasis, 2017
Eva-Luise, Hobl, Bernd, Jilma
openaire   +2 more sources

Indications of combined vitamin K antagonists and aspirin therapy [PDF]

, 2008
A. Loualidi, S. H. J. Bredie, Mirian C. H. Janssen   +2 more
openalex   +1 more source

Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality

Journal of the American Medical Association (JAMA), 2018
T. Inohara, Y. Xian, L. Liang, Roland A. Matsouaka, J. Saver, Eric E. Smith, L. Schwamm, M. Reeves, Adrian F. Hernandez, Deepak L. Bhatt, E. Peterson, G. Fonarow   +11 more
semanticscholar   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: executive summary.

Europace, 2018
J. Steffel, P. Verhamme, T. Potpara, P. Albaladéjo, M. Antz, L. Desteghe, Karl Georg Haeusler, J. Oldgren, H. Reinecke, V. Roldán-Schilling, N. Rowell, P. Sinnaeve, R. Collins, A. Camm, H. Heidbüchel, G. Lip, J. Weitz, L. Fauchier, D. Lane, G. Boriani, A. Goette, R. Keegan, R. Macfadyen, C. Chiang, B. Joung, W. Shimizu   +25 more
semanticscholar   +1 more source