Results 161 to 170 of about 206,382 (334)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

PCV14 AN APPRAISAL OF REAL-WORLD EVIDENCE (RWE) IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION (NVAF) TREATED WITH NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS (NOACS) [PDF]

, 2019
Steven Deitelzweig, Allie Cichewicz, M. DiFusco, A Kang, Cristina Russ, K. R. Snook, Evelien Bergrath, Amy Earley, J.C. Cappelleri   +8 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Direct oral anticoagulants (DOAC) versus vitamin K antagonist in left ventricular thrombus: An updated meta-analysis. [PDF]

Health Sci Rep, 2023
Shrestha DB, Dawadi S, Dhakal B, Shtembari J, Patel T, Shaikh R, Bodziock GM, Shantha G, Trankle CR, Patel NK.   +9 more
europepmc   +1 more source

Fondaparinux as an alternative to vitamin K antagonists in haemodialysis patients [PDF]

, 2013
Marijn M. Speeckaert, Katrien Devreese, Raymond Vanholder, Annemieke Dhondt   +3 more
openalex   +1 more source

Enhanced Recognition via Defect Engineered Amorphous Metal–Organic Framework for Sensitive and Stable Pesticide Biosensor

Advanced Science, EarlyView.
A defect‐engineered assembly strategy is reported for the in situ encapsulation of acetylcholinesterase (AChE) into amorphous MOF‐74, endowing the composite with superior catalytic activity and target recognition capability. Leveraging these structural advantages, a sensitive and stable biosensor is constructed for the detection of paraoxon pesticide ...
Changshun Su, Xiangyu Zhai, Meng Zhang, Mengxue Li, Xinru Zhang, Chunyan Sun, Xu Yan, Hongxia Li   +7 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. [PDF]

Korean J Intern Med, 2023
Lee KH, Park HW.
europepmc   +1 more source

Data on incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonist oral anticoagulants

, 2018
Daniele Pastori, Gregory Y.H. Lip, Alessio Farcomeni, Francesco Del Sole, Angela Sciacqua, Francesco Perticone, Rossella Marcucci, Elisa Grifoni, Pasquale Pignatelli, Francesco Violi, Mirella Saliola, Marco Casciaro, Danilo Menichelli, Francesco Cribari, Alberto Paladino, Rony Gingis, Marta Novo, Vittoria Cammisotto, Cristina Nocella, Simona Bartimoccia, Roberto Carnevale, Tiziana Di Stefano, Patrizia Iannucci, Elio Sabbatini, Luigi Anastasio, Joseph Tassone Eliezer   +25 more
openalex   +1 more source