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A COMPREHENSIVE REVIEW OF VITAMIN K AND VITAMIN K ANTAGONISTS
Hematology/Oncology Clinics of North America, 2000For more than 60 years, vitamin K-dependent proteins have been known to play an important role in regulating blood coagulation. During recent years it has become clear, however, that vitamin K is also involved in other physiologic processes, including bone metabolism and vascular biology.
C, Vermeer, L J, Schurgers
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Vitamin K and Vitamin K Antagonists
2020Vitamin Κ was discovered by Henrik Dam in 1929 in studies of sterol metabolism in chicks fed fat-free diets (1). The antihemorrhagic fat-soluble agent was called vitamin Κ, Κ being short for "Koagulation" (the German word for coagulation). Since then there have been two major eras of extensive research on this vitamin.
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1966
Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
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Publisher Summary Vitamin K activity is shared by a fairly large number of compounds. They consist, in the main, of two naturally occurring groups of compounds: phylloquinones (K), containing saturated isoprenoid side chains, and menaquinones (MK) with unsaturated isoprenoid side chains.
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Phenindione – uncommon vitamin K antagonist
Oral Surgery, 2020Abstract We would like to bring to your readership?s attention to the drug phenindione We came across this drug during a COVID-19 pandemic phone triage at our dental hospital A 48-year-old was referred for the management of a right sided facial swelling related to a carious unrestorable upper right molar She had a complex medical history, including ...
S. M. Nowak, B. Ahmed, M. Murphy
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Vitamin K Metabolism in a Patient Resistant to Vitamin K Antagonists
Pathophysiology of Haemostasis and Thrombosis, 1997We investigated various pharmacokinetic and pharmacody-namic parameters in a 63-year-old man, resistant to warfarin, fluindione, acenocoumarol and phenprocoumon. Daily doses of up to 30 mg of the long-acting phenprocoumon yielded a drug concentration of 85 mg/1 (usual range 1-5 mg/1) but the international normalized ratio remained around 1.
A, Keréveur +8 more
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Oral anticoagulation with vitamin K-antagonists
Therapeutische Umschau, 2003Coumarin-Derivate finden heute eine breite klinische Anwendung und sollten deswegen zur Gruppe der «vertrauten» Medikamente gehören. In der vorliegenden Übersichtsarbeit werden verschiedene Aspekte der Behandlung mit Vitamin K-Antagonisten beleuchtet: die Bedeutung von Vitamin K für die Synthese von funktionsfähigen Gerinnungsfaktoren, klinisch ...
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[Vitamin K antagonists overdose].
Przeglad lekarski, 2016Nowadays, anticoagulant therapy belongs to the most commonly used forms of pharmacotherapy in modern medicine. The most important representatives of anticoagulants are heparins (unfractionated heparin and low-molecular-weight heparin) and coumarin derivatives (vitamin K antagonists--VKA).
Barbara, Groszek, Paweł, Piszczek
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Vitamin K Antagonists – Current Concepts and Challenges
Thrombosis Research, 2011Vitamin K antagtonists (VKAs) have, for decades, been the corner-stone of anticoagulation in the outpatient setting. While the long half life makes once daily administration practical, close monitoring of VKA effect is necessary because these medicines have a narrow therapeutic index.
Hayan, Moualla, David, Garcia
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Bleeding risks associated with vitamin K antagonists
Blood Reviews, 2013Vitamin K antagonists are widely used for the prevention of stroke due to atrial fibrillation, treatment and secondary prevention of venous thromboembolism, prevention of valvular thromboembolism in patients with prosthetic heart valves, and secondary prevention of acute myocardial infarction.
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