Results 51 to 60 of about 250,312 (292)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Vitamin K deficiency bleeding leading to a diagnosis of Crohn’s Disease [PDF]

, 2014
We report the case of a 45 year old man who came to Emergency Room of Polyclinic for sudden onset of localized ecchymosis and widespread hematomas. He was subjected to blood count and first level investigations to assess coagulation. Based on the results,
AGNELLO, Luisa, BELLIA, Chiara, BIVONA, Giulia, Bonura, F, CARUSO, Antonietta, CIACCIO, Marcello, Coraci, F, Gnoffo, R, Lo Coco, L, LO SASSO, Bruna, NAPOLITANO, Mariasanta, Vitale, S   +11 more
core  

Global Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis. [PDF]

, 2019
The risk of adverse effects of nitrous oxide (N2O) exposure is insufficiently recognized despite its widespread use. These effects are mainly reported through case reports. We conducted an individual patient data meta-analysis to assess the prevalence of
Filhine-Tresarrieu, Pierre, Franczak, Claire, Green, Ralph, Guéant, Jean-Louis, Hajjar, Olivia, Julien, Mélissa, Laugel, Elodie, Levy, Julien, Oussalah, Abderrahim, Stephan, Charlotte, Wandzel, Marion   +10 more
core   +3 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

Journal of Medical Science, 2016
Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification.
Jan Krzysztof Nowak, Andrzej Wykrętowicz, Patrycja Krzyżanowska, Agnieszka Górna, Jarosław Tobolski, Edyta Mądry, Jarosław Walkowiak   +6 more
doaj   +1 more source

Congenital Vitamin K-Dependent Clotting Factors Deficiency Type 1: A Rare Bleeding Disorder

Dubai Medical Journal, 2020
Combined deficiency of vitamin K-dependent clotting factors is usually an acquired clinical problem, often resulting from liver disease, malabsorption or warfarin overdose. However, an inherited form of the disease is very rare.
Sura Ahmed Al-Doory, Mahmoud Ahmed Radaideh, Shafeeka Mohamed Saleh, Mohammed Ali Al Sabbah   +3 more
doaj   +1 more source

Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency. [PDF]

, 2019
Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED)
Bordbari, Matthew H, Durbin-Johnson, Blythe, Finno, Carrie J, Kang, Mincheol, Lee, Jeong H, Park, Seojin, Perez-Flores, Maria C, Peterson, Janel, Settles, Matthew, Yamoah, Ebenezer N   +9 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Assessment of Potential Biomarkers of Subclinical Vitamin K Deficiency in Patients with End-Stage Kidney Disease

Canadian Journal of Kidney Health and Disease, 2014
Background: A significant proportion of hemodialysis patients have functional, but modifiable, vitamin K deficiency. Objective: To determine the correlates of poor vitamin K status in hemodialysis patients. Design: Cross-sectional study.
Meghan J Elliott, Sarah L Booth, Wilma M Hopman, Rachel M Holden   +3 more
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source