Results 271 to 280 of about 1,433,545 (391)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Estimated Amounts of β-Carotene, Vitamin B6, Riboflavin and Niacin in the Daily Diet of Older Subjects Associate Negatively with ADP-Induced Aggregation of Blood Platelets Independently of Cardiovascular Risk Factors. [PDF]

Nutrients
Karolczak K, Guligowska A, Sołtysik BK, Kostanek J, Kostka T, Watala C.   +5 more
europepmc   +1 more source

Association of serum content of 25-hydroxy vitamin D with semen quality in normozoospermic and oligoasthenoteratozoospermic men.

, 2018
Elham Azizi, Mohammad Naji, Maryam Shabani-Nashtaei, Aligholi Aligholi, Atefeh Najafi, Fardin Amidi   +5 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and <i>in vivo</i> evidence. [PDF]

Front Immunol
Tang A, Gong Z, Shi Y, Zhang W, Jin M, Sun L, Chen W.   +6 more
europepmc   +1 more source

Role of Vitamin D and IgE in bronchial asthma in children in Eastern India

, 2017
Sk. Rafikul Rahaman
openalex   +1 more source

Homocysteine lowering with folic acid and B vitamins in vascular disease.

New England Journal of Medicine, 2006
E. Lonn, S. Yusuf, M. Arnold, P. Sheridan, J. Pogue, M. Micks, M. McQueen, J. Probstfield, G. Fodor, C. Held, J. Genest   +10 more
semanticscholar   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Wolbachia-supplemented B-vitamins are critical for blood digestion in the bed bug Cimex lectularius. [PDF]

Sci Rep
Wiles EL, Kakumanu ML, Schal C.
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source