Results 61 to 70 of about 175,057 (155)

Primary Central Nervous System Lymphomas: A Diagnostic Overview of Key Histomorphologic, Immunophenotypic, and Genetic Features

Diagnostics, 2020
Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma that primarily arises in the brain, spinal cord, leptomeninges, and vitreoretinal compartment of the eye.
Marietya I. S. Lauw, Calixto-Hope G. Lucas, Robert S. Ohgami, Kwun Wah Wen   +3 more
doaj   +1 more source

Long‐term outcomes of combined intravitreal methotrexate and systemic high‐dose methotrexate therapy in vitreoretinal lymphoma

Cancer Medicine, 2023
Objective The optimal treatment for vitreoretinal lymphoma (VRL) remains a challenge, as central nervous system (CNS) relapse occurs frequently, leading to the worst impact on survival.
Chieh‐Lung Cheng, Po‐Ting Yeh, Wei‐Quan Fang, Wei‐Li Ma, Hsin‐An Hou, Cheng‐Hong Tsai, Chang‐Ping Lin, Hwei‐Fang Tien   +7 more
doaj   +1 more source

Investigating Microinvasive Intra‐Ocular Biopsy

Clinical &Experimental Ophthalmology, Volume 53, Issue 8, Page 996-1007, November 2025.
ABSTRACT Background Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G for intraocular biopsy in the posterior and anterior segments.
Jared Ching, Shohei Kitahata, Hinako Ichikawa, Kazuaki Kadonosono   +3 more
wiley   +1 more source

Multimodal imaging in a case of presumed secondary vitreoretinal lymphoma presenting with inner retina and optic nerve head infiltration

American Journal of Ophthalmology Case Reports
Purpose: To report the findings supported by multimodal imaging in a case of secondary vitreoretinal lymphoma presenting with inner retina and optic nerve head infiltration.
Emily S. Levine, Nikhil N. Batra
doaj   +1 more source

Specific Marker Gene Analysis for Primary Central Nervous System Lymphoma Based on Methylation Difference and Development of Detection Primers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Promoter hypermethylation of the RHEB gene is identified as a specific biomarker for Primary Central Nervous System Lymphoma (PCNSL). This study develops methylation‐specific primers, demonstrating their power to distinguish PCNSL from other CNS diseases via a novel plasma‐based detection method.
Feng Yan, Yaming Wang, Xiaotong Fan, Penghu Wei, Yongzhi Shan   +4 more
wiley   +1 more source

How we diagnose and treat vitreoretinal lymphoma [PDF]

, 2016
The eye is a rare site for the development of malignant lymphoma. Based on cell type and involved intraocular structures, which as a whole represent an immune-privileged site, several subtypes of primary intraocular lymphoma need to be discerned. Primary
Andrés J. M. Ferreri, Ferreri, AJM, Fend, F, Sarah E. Coupland, Coupland, SE, Falko Fend   +5 more
core   +1 more source

Uveitis Masquerade Syndrome

Ukrainian Journal of Ophthalmology
The ‘uveitis masquerade syndrome’ is a large group of neoplastic and non-neoplastic conditions that mimic and are initially misdiagnosed as uveitis.
M. K. Shields, L. B. Ferreira, A. L. Farrall, J. R. Smith   +3 more
doaj   +1 more source

Secondary central nervous system lymphoma (SCNSL) in mantle cell lymphoma (MCL): Characteristics and risk factors in a Danish nationwide population‐based study

British Journal of Haematology, Volume 207, Issue 4, Page 1366-1376, October 2025.
In a nationwide cohort study, 873 patients with mantle cell lymphoma (MCL) were followed for a median of 7 years. During follow‐up, 28 patients developed secondary central nervous system (CNS) lymphoma (SCNSL) with a 5‐year cumulative incidence of 2.8% (95% confidence interval [CI] 1.7–3.9).
Trine Trab, Torgerð Ranadóttir, Iman Chanchiri, Ahmed Ludvigsen Al‐Mashhadi, Emma Berggreen Dall, Stine Rasch, Mette Johansen, Laura Mors Haunstrup, Gabriella Cunsolo, Christian Bjørn Poulsen, Thomas Stauffer Larsen, Simon Husby, Peter Brown, Eliza A. Hawkes, Tarec C. El‐Galaly, Kirsten Grønbæk   +15 more
wiley   +1 more source

Combined treatment of primary vitreoretinal lymphomas significantly prolongs the time to first relapse

, 2018
BackgroundVitreoretinal lymphomas belong to the family of central nervous system (CNS) lymphomas. The optimal approach for the treatment of isolated primary vitreoretinal lymphoma is unclear because of the lack of large comparative clinical series ...
Robert Pytlik, Aneta Klimova, Jana Karolova, Ivan Spicka, Petra Svozilkova, Jarmila Heissigerova, Katerina Mrazova, Eva Rihova, Michaela Brichova   +8 more
core   +1 more source

Primary Vitreoretinal Lymphoma Presenting as a Posterior Capsule Plaque

, 2018
Primary vitreoretinal lymphoma (PVRL) can be a diagnostic challenge and commonly presents as a partially steroid-responsive vitritis or as subretinal cream-colored infiltrates.
Sander R. Dubovy, Garoon, Robert B, Thomas A. Albini, Jay S. Duker, Rehan M. Hussain, Hussain, Rehan M, Dubovy, Sander R, Robert B. Garoon, Duker, Jay S, Albini, Thomas A   +9 more
core   +1 more source