Results 81 to 90 of about 9,502 (214)

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Leveraging AAV1-Rac1T17N to prevent experimental proliferative vitreoretinopathy

Journal of Translational Medicine
Background Platelet-derived growth factor receptor β (PDGFRβ) is the principal PDGFR isoform in retinal pigment epithelial (RPE) cells from the epiretinal membranes of patients with proliferative vitreoretinopathy (PVR).
Duo Li, Minli Linghu, Jisen Tang, Gukun Yang, Chuanwu Li, Hang Yao, Hetian Lei, Yikeng Huang, Xionggao Huang   +8 more
doaj   +1 more source

Human cytokines activate JAK–STAT signaling pathway in porcine ocular tissue [PDF]

, 2015
Background: The JAK/STAT (Janus Tyrosine Kinase, Signal Transducers and Activators of Transcription) pathway is associated with cytokine or growth factor receptors and it is critical for growth control, developmental regulation and homeostasis.
Barteneva, Natasha S, Fasler-Kan, Elizaveta, Flammer, Josef, Huwyler, Jörg, Ketterer, Sylvia, Meyer, Peter, Nurzhanova, Asil, Reschner, Anca, Wunderlich, Kerstin   +8 more
core   +1 more source

A sustained dual drug delivery system for proliferative vitreoretinopathy

Drug Delivery, 2020
Proliferative vitreoretinopathy (PVR) is a significant threat for vision recovery from retinal detachment or ocular trauma. Currently, no approved pharmacological intervention to prevent PVR.
Ying Xiao, Kyung Seek Choi, David Warther, Kristyn Huffman, Stephanie Landeros, William R. Freeman, Michael J. Sailor, Lingyun Cheng   +7 more
doaj   +1 more source

Dual‐Crosslinked Betaine‐Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti‐Adhesion, Anti‐Fouling, and Anti‐Cell Proliferation

Advanced Science, Volume 12, Issue 36, September 25, 2025.
A novel multiple cross‐linked betaine‐type amphiphilic polymer hydrogels are developed via in situ free radical copolymerization. The resultant formation, named P(SBMA‐co‐AANa) hydrogel, functions as a vitreous substitute and demonstrates superior performance in optical properties, support capacity, and biocompatibility on a vitrectomized rabbit model.
Yuting Cai, Yun Tan, Jian Cao, Xiaoyuan Zhou, Xingyuan Li, Jianghua Li, Chuntai Liu, Yi Zhang, Yun Li   +8 more
wiley   +1 more source

Intravitreal methotrexate infusion for proliferative vitreoretinopathy

Clinical Ophthalmology, 2016
Ama Sadaka,1 Robert A Sisk,1–3 James M Osher,1,3 Okan Toygar,4 Melinda K Duncan,5 Christopher D Riemann1,3 1Department of Ophthalmology, University of Cincinnati College of Medicine, 2Department of Opthalmology, Cincinnati Children’s ...
Sadaka A, Sisk RA, Osher JM, Toygar O, Duncan MK, Riemann CD   +5 more
doaj  

Revolving Forcep Technique for Subretinal Band Removal

Delhi Journal of Ophthalmology
Subretinal bands (SRBs) are a form of proliferative vitreoretinopathy which is usually seen associated with chronic retinal detachment. SRBs prevent retinal reattachment after the surgery and thus it needs to be removed. Here, we report a novel technique
Kaustubh Rewatkar, Amit S. Nene, Smitesh Shah, Pushpanjali Badole, Prateek Shenoy, Onkar H. Pirdankar   +5 more
doaj   +1 more source

Inflammatory and angiogenic protein detection in the human vitreous : cytometric bead assay [PDF]

, 2011
Introduction. To evaluate clinical feasibility and reproducibility of cytometric bead assay (CBA) in nondiluted vitreous samples of patients with age-related macular degeneration (ARMD), diabetic macular edema (DME), and central retinal vein occlusion ...
Koch, Frank H., Koss, Michael Janusz, Pfister, Marcel   +2 more
core  

Suprachoroidal collection of internal tamponading agents through a choroidal hole

Indian Journal of Ophthalmology, 2008
We report two cases of significantly large choroidal holes following penetrating trauma that led to suprachoroidal migration of internal tamponading agents during repair of retinal detachments with proliferative vitreoretinopathy secondary to penetrating
Gopal Lingam, Mittal Nishank, Verma Aditya   +2 more
doaj  

Proliferative vitreoretinopathy and its relationship with inflammatory serum biomarkers [PDF]

International Journal of Ophthalmology
AIM: To analyze if a relationship between levels of inflammatory serum biomarkers and severity of primary proliferative vitreoretinopathy (PVR) exists. METHODS: A retrospective case-control study.
Victor Alejandro Martinez Pacheco, Sergio Rojas Juarez, Braulio Hernan Velasco Sepulveda, Abel Ramirez Estudillo   +3 more
doaj   +1 more source