Results 61 to 70 of about 9,502 (214)

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice

Nature Communications
Proliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch’s membrane on the scleral ...
Min Luo, Dena Almeida, Valentina Dallacasagrande, Nadia Hedhli, Mrinali Gupta, Donald J. D’Amico, Szilárd Kiss, Katherine A. Hajjar   +7 more
doaj   +1 more source

Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness

iScience, 2020
Summary: Rare diseases are an emerging global health priority. Although individually rare, the prevalence of rare “orphan” diseases is high, affecting approximately 300 million people worldwide.
Gabriel Velez, Vinit B. Mahajan
doaj   +1 more source

Cytokines in proliferative vitreoretinopathy [PDF]

Eye, 1991
This study determined the presence of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour necrosis factor alpha (TNF alpha), tumour necrosis factor beta (TNF beta), interferon gamma (IFN gamma), transforming growth factor beta 2 (TGF beta 2) and fibroblast proliferation activity (FPA) in vitreous aspirates from eyes undergoing vitrectomy for the ...
G A, Limb, B C, Little, A, Meager, J A, Ogilvie, R A, Wolstencroft, W A, Franks, A H, Chignell, D C, Dumonde   +7 more
openaire   +2 more sources

Anterior proliferative vitreoretinopathy in a patient with Coats disease [PDF]

International Journal of Ophthalmology, 2018
Letter to the ...
Satoru Kase, Shohei Mori, Kousuke Noda, Susumu Ishida   +3 more
doaj   +1 more source

Tolerability and Efficacy of Multiple Series of Intravitreal Methotrexate Injections for Complex Retinal Detachment Associated with Proliferative Vitreoretinopathy

Future Pharmacology, 2023
In this study, we retrospectively reviewed the outcomes of patients treated with one or more series of intravitreal methotrexate (MTX) injections as a surgical adjunct for the prevention of recurrent rhegmatogenous retinal detachment (RRD) related to ...
Tessnim R. Ahmad, Jay M. Stewart
doaj   +1 more source

The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial [PDF]

, 2010
Background: Blood-retinal barrier breakdown secondary to retinal detachment and retinal detachment repair is a factor in the pathogenesis of proliferative vitreoretinopathy (PVR). We wished to investigate whether an estimated 700 to 1000 ng/ml subretinal
Bali, E. (Ernesto), Feron, E.J. (Eric), Meurs, J.C. (Jan) van, Mulder, P.G.H. (Paul), Peperkamp, E. (Ed), Veckeneer, M.A.H. (Marc)   +5 more
core   +3 more sources

Interventions for submacular haemorrhage: A systematic review and network meta‐analysis of controversies—On behalf of the Spanish Vitreo‐Retinal Society (SERV)

Acta Ophthalmologica, Volume 104, Issue 2, Page 139-163, March 2026.
Abstract Purpose This systematic review aims to evaluate and synthesize the existing literature on the interventions used for submacular haemorrhage (SMH), highlighting the controversies and differences in clinical practice. Method A systematic review was conducted following the PRISMA guidelines.
Salvador Pastor‐Idoate, Pablo Redruello‐Guerrero, Laura de Juan Hernández, Gregorio Benites‐Narcizo, Mario Rivera‐Izquierdo, José García‐Arumí, José Carlos Pastor Jimeno   +6 more
wiley   +1 more source

The impact of octreotide in experimental proliferative vitreoretinopathy

Indian Journal of Ophthalmology, 2013
Aims: This study aims to investigate the effects of intravitreal octreotide on the growth factors, which have significant roles in the pathogenesis of proliferative vitreoretinopathy (PVR). Settings and Design: An experimental trial.
Ozge Evren, Burak Turgut, Ulku Celiker, Kadir Ates   +3 more
doaj   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Proliferative Vitreoretinopathy: A Review [PDF]

International Ophthalmology Clinics, 2019
Proliferative vitreoretinopathy (PVR) is the most common cause for failure of rhegmatogenous retinal detachment repair and is characterized by the growth and contraction of cellular membranes within the vitreous cavity and on both sides of the retinal surface as well as intraretinal fibrosis.
Sana, Idrees, Jayanth, Sridhar, Ajay E, Kuriyan   +2 more
openaire   +2 more sources