Results 41 to 50 of about 114,620 (205)

Transmission electron microscopy of the vitreous body tissue in chronic hemophthalmos

Veterinární Medicína, 2005
Haemolytic products arising in chronic hemophthalmos cause cellular infiltration, necrosis of the vitreous structure, and fibrous membrane formation. In this process, retinal pigment epithelium plays an important role for its antioxidant properties and ...
S. Synek, L. Pac
doaj   +1 more source

A Practical Guide to Optimal Adaptive Two‐Stage Designs for Various Endpoint Types

Pharmaceutical Statistics, Volume 25, Issue 6, November/December 2026.
ABSTRACT Adaptive designs are frequently used to adjust sample sizes based on interim data, ensuring reliable conclusions while protecting resources. To maximize trial efficiency, design parameters can be optimized to minimize an objective function (e.g., the expected sample size) while rigorously controlling overall error rates or further operating ...
Nico Bruder, Jan Meis, Maximilian Pilz, Meinhard Kieser   +3 more
wiley   +1 more source

Clinicopathologic Correlation of a Subretinal Proliferative Vitreoretinopathy Band in a Patient with Chronic Recurrent Retinal Detachment

Case Reports in Ophthalmology, 2018
Purpose: Proliferative vitreoretinopathy is a well-known cause of failure of retinal detachment surgery. The purpose of this case report is to illustrate the clinical occurrence and histopathology of a horizontal subretinal band (“clothesline ...
Karen R. Brown, Sander R. Dubovy, Nidhi Relhan, Harry W. Flynn Jr.   +3 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, Volume 13, Issue 54, 28 September 2026.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Tolerability and Efficacy of Multiple Series of Intravitreal Methotrexate Injections for Complex Retinal Detachment Associated with Proliferative Vitreoretinopathy

Future Pharmacology, 2023
In this study, we retrospectively reviewed the outcomes of patients treated with one or more series of intravitreal methotrexate (MTX) injections as a surgical adjunct for the prevention of recurrent rhegmatogenous retinal detachment (RRD) related to ...
Tessnim R. Ahmad, Jay M. Stewart
doaj   +1 more source

Syntaxin‐3 Regulates Tight Junction Assembly in Human Retinal Pigment Epithelium

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood to be absent in human RPE ...
Athira Ramesh, Suganya Sivagurunathan, Navya Valavath Baburajan, Subbulakshmi Chidambaram   +3 more
wiley   +1 more source

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice

Nature Communications
Proliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch’s membrane on the scleral ...
Min Luo, Dena Almeida, Valentina Dallacasagrande, Nadia Hedhli, Mrinali Gupta, Donald J. D’Amico, Szilárd Kiss, Katherine A. Hajjar   +7 more
doaj   +1 more source

Current Landscape and Future Perspectives of Diabetic Retinopathy Therapy: Pharmacological Targets, Precision Laser Technology, and Clinical Evidence

MedComm, Volume 7, Issue 7, July 2026.
Targeted biological agents targeting VEGF, integrin, dopamine D2 receptor, ROCK, and BCL‐XL have entered the clinical trial phase and deserve particular attention. The treatment paradigm has shifted toward personalized and precision medicine, positioning optimized SML as a promising adjunctive therapy.
Xinying Hu, Zhe Cha, Ao Lu, Wuping Xu, Xiaoqing Zhang, Sheng Miao, Haiwei Xu, Xuedong Xu   +7 more
wiley   +1 more source

p21CIP/WAF1 saRNA inhibits proliferative vitreoretinopathy in a rabbit model.

PLoS ONE, 2023
PurposeProliferative vitreoretinopathy (PVR) is a disease process resulting from proliferation of retinal pigment epithelial (RPE) cells in the vitreous and periretinal area, leading to periretinal membrane formation and traction and eventually to ...
Qi Zhang, Yangchen Guo, Moorim Kang, Wei-Hsiang Lin, Jian-Cheng Wu, Ying Yu, Long-Cheng Li, Aimin Sang   +7 more
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source