Results 81 to 90 of about 69,762 (263)

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu   +4 more
wiley   +1 more source

Light-induced disassembly of dusty bodies in inner protoplanetary discs: implications for the formation of planets [PDF]

open access: yes, 2007
Laboratory experiments show that a solid-state greenhouse effect in combination with thermophoresis can efficiently erode a dust bed in a low-pressure gaseous environment.
Alexander   +44 more
core   +1 more source

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

open access: yesMacromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani   +6 more
wiley   +1 more source

Kafirin structure and functionality [PDF]

open access: yes, 2006
The structural and functional properties of kafirins are reviewed. Three classes of kafirin: the a, ß and ? forms have been identified at the protein level and one, the d, has been identified only at the gene and transcript levels.
Argos   +60 more
core   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo   +4 more
wiley   +1 more source

The scale matters: A review on stimuli‐responsive microrobots categorized by scale for biomedical applications

open access: yesResponsive Materials, EarlyView.
We systematically summarize how each scale dictates fundamental choices in design feature, manufacturing technology, driving mechanism, and control strategy, which are inherently governed by scale‐dominated physical principles. Furthermore, the application of scale‐determined operation modes of microrobots across different stages of medical ...
Hang Yin   +3 more
wiley   +1 more source

25G Ultrasonic Vitrectomy in Surgical Treatment of Idiopathic Macular Hole

open access: yesКреативная хирургия и онкология, 2019
Introduction. Idiopathic macular hole (IMH) is a frequent disorder of the posterior segment of the eye that impacts on visual functions leading to the reduction of visual acuity and the manifestation of metamorphopsia.
B. M. Aznabaev   +2 more
doaj   +1 more source

Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates. [PDF]

open access: yes, 2020
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and ...
Chung, Sook Hyun   +7 more
core  

DNA methylation and epigenomic profiling post‐mortem of human remain analogs (Sus scrofa) in southern Ontario, Canada

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract Understanding the dynamics of DNA methylation (DNAm) post‐mortem could support forensic applications, particularly the estimation of the post‐mortem interval (PMI), age, and sex of remains. In this study, we investigated DNAm changes in pig carcasses (Sus scrofa) as analogs for human decomposition, while measuring the progression of decay ...
Irina Badell   +4 more
wiley   +1 more source

Optical coherent tomography in diagnoses of peripheral retinal degenarations

open access: yesOftalʹmologiâ, 2014
Purpose: Studying the capabilities of optical coherence tomography (RTVue-100, OPTOVUE, USA) in evaluation of peripheral retinal degenerations, vitreoretinal adhesions, adjacent vitreous body as well as measurement of morphometric data.Methods: The study
O. G. Pozdeyeva   +6 more
doaj   +1 more source

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