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Current Situation and Challenges in Vitreous Substitutes [PDF]

open access: yesMacromolecular Bioscience, 2021
AbstractVitreo‐retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo‐retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous substitutes that are used in clinical practice are mainly divided into gases (air, SF6, C2F6, C3F8) and liquids ...
Ana Castro-Balado   +2 more
exaly   +7 more sources

IV.G. Physiology of Vitreous Substitutes

open access: yes, 2014
Human vitreous is a natural intraocular polymeric hydrogel with distinct biochemical and physiological functions. Surgical removal of the vitreous, or vitrectomy, is now commonly performed for the treatment of many vitreoretinal diseases. This has led to
Ning Cheung, David Wong, Cheung Ning
exaly   +3 more sources
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Vitreous Substitutes: A Comprehensive Review

Survey of Ophthalmology, 2011
Vitreoretinal disorders constitute a significant portion of treatable ocular disease. Advances in vitreoretinal surgery have included the development and characterization of suitable substitutes for the vitreous. Air, balanced salt solutions, perfluorocarbons, expansile gases, and silicone oil serve integral roles in modern vitreoretinal surgery ...
Radouil Tzekov   +2 more
exaly   +4 more sources

Vitreous Substitution With Gases

Archives of Ophthalmology, 1975
The effects of vitreous substitution with air, a sulfur hexafluoride-air mixture, an octafluorocyclobutane-air mixture, and physiological saline were compared in owl monkeys. Each gas caused an increase in ocular vascular permeability greater than that caused by saline, as measured by vitreous inflow of serum protein labeled with iodine I 131 and ...
I J, Constable, D A, Swann
openaire   +2 more sources

VITREOUS SUBSTITUTE

Retina, 1984
We studied a synthetic hydrogel, PHEA [poly(2-hydroxyethyl acrylate)], experimentally. The material is transparent, autoclavable , highly viscous, nonabsorbable, easily injectable, cohesive, and does not fragment on passage through small-gauge needles.
I M, Chan   +4 more
openaire   +2 more sources

Vitreous Substitutes

Vitreous substitutes are required in numerous vitreoretinal surgical procedures, including retinal detachment repair. Current vitreous substitutes – namely gases and oils – are suboptimal, inconvenient and inefficient for patient recovery. Herein we examine polymeric hydrogels derived from synthetic or natural sources as alternative vitreous ...
André B. Castelo Branco   +2 more
  +4 more sources

In Vitro Biocompatibility of New PVA-Based Hydrogels as Vitreous Body Substitutes

open access: yesJournal of Biomaterials Science, Polymer Edition, 2012
In order to synthesize injectable hydrogels suitable as vitreous body substitutes, a new method based on the use of trisodium trimetaphosphate (STMP) to cross-link PVA was recently proposed. Hydrogels with different molar ratios between STMP and PVA were
Stefania Lamponi   +2 more
exaly   +2 more sources

Polygeline as a Vitreous Substitute

Archives of Ophthalmology, 1966
In a previous article the experimental replacement of vitreous by polygeline (Haemaccel, Great Britain and Germany) in rabbits was discussed. 1 Since the results of these experiments were favorable, the author applied the solution clinically in cases of retinal detachment. Material and Method The commercially available 3.5% solution of polygeline was
J A, Oosterhuis   +3 more
openaire   +4 more sources

Experiments with haemaccel as a vitreous substitute

Experimental Eye Research, 1966
Haemaccel, a polypeptide prepared from gelatin, generally used as a plasma volume expander, has been tried as a substitute for vitreous in rabbits. The rate of elimination of Haemaccel from the vitreous body was determined, 22·5% being left after 10 days.
N J, van Haeringen   +3 more
openaire   +2 more sources

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