Results 31 to 40 of about 3,431 (127)

Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia

Frontiers in Immunology, 2023
Coronavirus disease 2019 (COVID-19) is known to commonly induce a thrombotic diathesis, particularly in severely affected individuals. So far, this COVID-19-associated coagulopathy (CAC) has been partially explained by hyperactivated platelets as well as
Johannes Hirsch, Johannes Hirsch, Günalp Uzun, Günalp Uzun, Jan Zlamal, Jan Zlamal, Anurag Singh, Tamam Bakchoul, Tamam Bakchoul   +8 more
doaj   +1 more source

Risk of venous thromboembolism after SARS-CoV-2 vaccination-Evidence from genome-wide association study and population-based observational study. [PDF]

Br J Clin Pharmacol
Aim We aimed to investigate whether genetic variation is associated with venous thromboembolism after immunization with SARS‐CoV‐2 vaccines. Methods We conducted a genome‐wide association study (GWAS) on cases of venous thromboembolism within 42 days after SARS‐CoV‐2 vaccination, recruited from reports of adverse drug reactions sent to the Swedish ...
Attelind S, Eriksson N, Cavalli M, Xu Y, Nyberg F, Sundström A, Wadelius M, Hallberg P.   +7 more
europepmc   +2 more sources

Beyond platelet activation: dysregulated lipid metabolism in defining risk and pathophysiology of VITT

Research and Practice in Thrombosis and Haemostasis
Background: VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such as ChAdOx1-S (Oxford/AstraZeneca) vaccination.
Hannah Stevens, James D. McFadyen, Natalie A. Mellett, David J. Lynn, Thy Duong, Corey Giles, Jane James, Rochelle Botten, Georgina Eden, Miriam Lynn, Paul Monagle, Peter J. Meikle, Sanjeev Chunilal, Karlheinz Peter, Huyen Tran   +14 more
doaj   +1 more source

Clinical significance of hepatosplenic thrombosis in vaccine-induced immune thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination

International Journal of Infectious Diseases, 2022
Background: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare, serious complication after adenoviral COVID-19 vaccine administration that can involve various organ systems.
Jimin Hwang, Young Joo Han, Dong Keon Yon, Seung Won Lee, Beom Kyung Kim, Se Bee Lee, Min Ho Lee, Seung Hyun Park, Ai Koyanagi, Louis Jacob, Kalthoum Tizaoui, Seung Up Kim, Jae Il Shin, Lee Smith   +13 more
doaj   +1 more source

Experience of danaparoid to treat vaccine-induced immune thrombocytopenia and thrombosis, VITT

Thrombosis Journal, 2022
Background Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is triggered by nCOV-19 adenovirus-vectored vaccines against SARS-CoV2. Pathogenesis has been mainly related to platelet activation via PF4-reactive antibodies that activate ...
Lasse Myllylahti, Hanna Pitkänen, Harry Magnani, Riitta Lassila   +3 more
doaj   +1 more source

Detection of Platelet-Activating Antibodies Associated with Vaccine-Induced Thrombotic Thrombocytopenia by Flow Cytometry: An Italian Experience

Viruses, 2022
Rare cases of thrombocytopenia and thrombosis after anti-COVID-19 adenovirus-associated mRNA vaccines (VITT) due to platelet-activating anti-platelet-factor 4 (PF4)/polyanion antibodies have been reported.
Francesca Cesari, Silvia Sorrentino, Anna Maria Gori, Angela Rogolino, Raimondo De Cristofaro, Betti Giusti, Elena Sticchi, Erica De Candia, Rossella Marcucci   +8 more
doaj   +1 more source

Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19

Life, 2022
Vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous sinus thrombosis (CVST) has been recently reported after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Wojciech Szypowski, Aleksander Dębiec, Jarosław Świstak, Maciej Nowocień, Piotr Rzepecki, Marcin Możański, Jacek Staszewski, Adam Stępień   +7 more
doaj   +1 more source

Drivers of tail evolution in squamates and their implications for the fossorial origin of snakes

The Anatomical Record, EarlyView.
Abstract The axial skeleton serves as the primary structural support in all vertebrates and is subdivided into five distinct regions: cervical, thoracic, lumbar, sacral, and caudal. Relaxation of constraints acting on the terminal end of the axial skeleton has led to remarkable variation in caudal vertebrae number across Squamata.
Olivia Binfield, Marco Camaiti, Lucy Roberts   +2 more
wiley   +1 more source

Antibodies against Platelet Glycoproteins in Clinically Suspected VITT Patients

Antibodies
Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but severe complication following COVID-19 vaccination, marked by thrombocytopenia and thrombosis. Analogous to heparin-induced thrombocytopenia (HIT), VITT shares similarities in anti-platelet
Romy T. Meier, Leendert Porcelijn, Suzanne Hofstede-van Egmond, Camila Caram-Deelder, Jonathan M. Coutinho, Yvonne M. C. Henskens, Marieke J. H. A. Kruip, An K. Stroobants, Jaap J. Zwaginga, C. Ellen van der Schoot, Masja de Haas, Rick Kapur   +11 more
doaj   +1 more source

Morphophysiological dynamics of the proximal post‐testicular ducts in Crotalus durissus Linnaeus, 1758 (Squamata: Viperidae)

The Anatomical Record, EarlyView.
Abstract The organization and function of reptilian excurrent ducts remain poorly characterized, particularly in Neotropical snakes. We provide the first integrative morphological, histochemical, immunohistochemical, and ultrastructural analysis of the proximal post‐testicular ducts of Crotalus durissus across reproductive stages.
Flávia Cappuccio de Resende, Gustavo Caldeira Cotta, Clara d' Ávila Fonseca Paiva de Paula Freitas, Leonardo Carvalho, Heloísa Helena Marques Oliveira, Victória Gomes Carvalho Silva, Lívia de Fátima Moreira Silva, Luciana Maria Silva, Samyra Maria dos Santos Nassif Lacerda, Guilherme Mattos Jardim Costa   +9 more
wiley   +1 more source