Results 1 to 10 of about 3,580 (126)

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis [PDF]

Advanced Science
Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
doaj   +3 more sources

Sepsis-induced immunothrombosis: from cellular crosstalk to multiple organ dysfunction [PDF]

Frontiers in Immunology
Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection; moreover, multiple organ failure is a major contributor to mortality.
Zhiyuan Guo, Zhiyuan Guo, Zhiyuan Guo, Guangyan Zhu, Guangyan Zhu, Guangyan Zhu, Min Wang, Ping Liu, Ping Liu, Ping Liu, Minghe Tan, Minghe Tan, Minghe Tan, Lisha Yi, Lisha Yi, Lisha Yi, Haifa Xia, Haifa Xia, Haifa Xia   +18 more
doaj   +2 more sources

The Immuno-Cardiovascular Storm of Pre-Eclampsia: Cytokine-Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability. [PDF]

Compr Physiol
Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Obeagu EI.
europepmc   +2 more sources

Endothelial dysfunction and immunothrombosis in sepsis

Frontiers in Immunology, 2023
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction caused by a dysregulated or over-reactive host response to infection.
Kimon Stamatelopoulos, Konstantinos Stellos, Simon Tual-Chalot   +2 more
exaly   +3 more sources

ADAMTS13 as a thromboinflammatory brake at the vascular-immune interface: from viral immunothrombosis to the tumor microenvironment [PDF]

Frontiers in Immunology
ADAMTS13 is conventionally regarded as the protease whose severe deficiency causes thrombotic thrombocytopenic purpura (TTP). By cleaving shear-unfolded ultra-large and high-molecular-weight von Willebrand factor (VWF), ADAMTS13 limits a platelet- and ...
Peng Huang, Xiaoyu Sun, Jie Peng, Wei Tian   +3 more
doaj   +2 more sources

Endotheliopathy in CAR T-Cell Therapy: Mechanistic Insights into the VWF/ADAMTS13 Axis and the Angiopoietin–Tie2 Pathway [PDF]

TH Open
Chimeric antigen receptor (CAR) T cell therapy has transformed the management of hematologic malignancies, yet its clinical success is tempered by severe immune-mediated toxicities, including cytokine-release syndrome (CRS) and immune effector cell ...
Sévérine de Bruijn, Inge Vangenechten, Sébastien Anguille, Alain Gadisseur   +3 more
doaj   +2 more sources

Could persistent extravascular fibrin deposition link microvascular and interstitial pathology in long COVID? [PDF]

Frontiers in Medicine
Long COVID is associated with persistent endothelial dysfunction, microvascular impairment, coagulation abnormalities, impaired fibrinolysis, and tissue hypoxia.
Keiko Kubo
doaj   +2 more sources

Therapeutic role of low molecular weight heparin and fat-soluble vitamins in pregnancy-associated prethrombotic conditions [PDF]

Frontiers in Medicine
Pregnancy is a physiological hypercoagulable state associated with an increased risk of venous thromboembolism (VTE) and other prethrombotic conditions that contribute significantly to maternal and fetal morbidity and mortality.
He Yanhong, He Cuiyi, Yu Ruiling, Huang Guowei   +3 more
doaj   +2 more sources

Case Report: Anti-platelet factor 4 -mediated immunothrombosis in a patient with ANCA vasculitis – a shared mechanism of NETosis

Frontiers in Immunology
Anti-platelet factor 4 (PF4) immunothrombosis is characterized by thrombocytopenia, thrombosis and enhanced NETosis and has been described in the absence of prior heparin exposure.
Etty Kruzel-Davila, Luiza Akria
exaly   +3 more sources

Evaluation of Glutathione in Spike Protein of SARS-CoV-2 Induced Immunothrombosis and Cytokine Dysregulation

Antioxidants
Thrombotic microangiopathy has been identified as a dominant mechanism for increased mortality and morbidity in coronavirus disease 2019 (COVID-19). In the context of severe COVID-19, patients may develop immunothrombosis within the microvasculature of ...
Vishwanath Venketaraman, Kayvan Sasaninia, Ira Glassman   +2 more
exaly   +3 more sources