Results 21 to 30 of about 4,210 (150)

Extracorporeal Membrane Oxygenation (ECMO)-Associated Coagulopathy in Adults

Diagnostics, 2023
Extracorporeal membrane oxygenation (ECMO) is used for the management of severe respiratory and cardiac failure and as a bridge to achieve definite treatment or transplantation.
Frantzeska Frantzeskaki, Dimitrios Konstantonis, Michail Rizos, Vasileios Kitsinelis, Georgios Skyllas, Ioannis Renieris, Maria Doumani, Vasileios Kolias, Eirini Kefalidi, Dimitrios Angouras, Argyrios Tsantes, Iraklis Tsangaris   +11 more
doaj   +1 more source

Platelet mTOR Is a Regulator of Sterile Immunothrombosis. [PDF]

Arterioscler Thromb Vasc Biol
: BACKGROUND Immunothrombosis entails a tight interplay between thrombotic and inflammatory pathways and plays a pathological role in ischemic stroke and venous thrombosis. The mTOR (mechanistic target of rapamycin) is a canonical serine/threonine kinase
Denorme F, Portier I, Castro H, Ajanel A, Kosaka Y, Benzon H, De Araujo CV, Souvenir R, Abel ED, Weyrich AS, Rondina MT, Campbell RA.   +11 more
europepmc   +2 more sources

The emerging role of immunothrombosis in paediatric conditions [PDF]

, 2019
Background: Immunothrombosis is a physiological process based on the release of neutrophil extracellular traps (NETs) to immobilise, contain and kill bacteria.
Franchi, T, Eaton, S, Giuliani, S, De Coppi, P   +3 more
core   +3 more sources

JAK2 Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms

Biomolecules, 2022
The JAK2V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1 negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G ˃ T at position 1849 and results in the substitution of valine with ...
Dania G. Torres, Jhemerson Paes, Allyson G. da Costa, Adriana Malheiro, George V. Silva, Lucivana P. de Souza Mourão, Andréa M. Tarragô   +6 more
doaj   +1 more source

Performance of D-dimer to lymphocyte ratio in predicting the mortality of COVID-19 patients

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundNowadays, there is still no effective treatment developed for COVID-19, and early identification and supportive therapies are essential in reducing the morbidity and mortality of COVID-19.
Fei Peng, Qiong Yi, Quan Zhang, Jiayi Deng, Cheng Li, Min Xu, Chenfang Wu, Yanjun Zhong, Shangjie Wu   +8 more
doaj   +1 more source

Mechanisms of COVID-19 Associated Pulmonary Thrombosis: A Narrative Review

Biomedicines, 2023
COVID-19, the infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is frequently associated with pulmonary thrombotic events, especially in hospitalized patients.
Cristian-Mihail Niculae, Adriana Hristea, Ruxandra Moroti   +2 more
doaj   +1 more source

Vitronectin promotes immunothrombotic dysregulation in the venular microvasculature

Frontiers in Immunology, 2023
Microvascular immunothrombotic dysregulation is a critical process in the pathogenesis of severe systemic inflammatory diseases. The mechanisms controlling immunothrombosis in inflamed microvessels, however, remain poorly understood. Here, we report that
Bernd Uhl, Bernd Uhl, Florian Haring, Florian Haring, Julia Slotta-Huspenina, Joshua Luft, Joshua Luft, Vera Schneewind, Vera Schneewind, Jonas Hildinger, Jonas Hildinger, Zhengquan Wu, Zhengquan Wu, Katja Steiger, Bojan Smiljanov, Bojan Smiljanov, Aarif M. N. Batcha, Aarif M. N. Batcha, Oliver T. Keppler, Oliver T. Keppler, Johannes C. Hellmuth, Johannes C. Hellmuth, Tobias Lahmer, Konrad Stock, Bernhard G. Weiss, Martin Canis, Konstantin Stark, Thomas Bromberger, Markus Moser, Christian Schulz, Wilko Weichert, Gabriele Zuchtriegel, Gabriele Zuchtriegel, Christoph A. Reichel, Christoph A. Reichel   +34 more
doaj   +1 more source

Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients

Frontiers in Immunology, 2022
IntroductionCoronavirus disease 2019 (COVID-19) can cause life-threatening acute respiratory distress syndrome (ARDS). Recent data suggest a role for neutrophil extracellular traps (NETs) in COVID-19-related lung damage partly due to microthrombus ...
Renaud Prével, Renaud Prével, Annabelle Dupont, Sylvie Labrouche-Colomer, Sylvie Labrouche-Colomer, Geoffrey Garcia, Antoine Dewitte, Antoine Dewitte, Antoine Rauch, Julien Goutay, Morgan Caplan, Elsa Jozefowicz, Jean-Philippe Lanoix, Jean-Philippe Lanoix, Julien Poissy, Etienne Rivière, Etienne Rivière, Arthur Orieux, Denis Malvy, Didier Gruson, Didier Gruson, Loic Garçon, Sophie Susen, Chloé James, Chloé James   +24 more
doaj   +1 more source

COVID‐19 and immunothrombosis: emerging understanding and clinical management [PDF]

, 2021
The COVID-19 pandemic has been the most significant health crisis in recent global history. Early studies from Wuhan highlighted COVID-19-associated coagulopathy and a significant association with mortality was soon recognised.
Toh, Cheng Hock, Guozheng Wang, Toh, CH, Shaw, Rebecca J, Shaw, RJ, Simon T. Abrams, Abrams, ST, Wang, Guozheng, Wang, G, Abrams, Simon T, Cheng‐Hock Toh, Bradbury, C, Bradbury, Charlotte, Rebecca J. Shaw, Charlotte Bradbury   +14 more
core   +1 more source

The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia

Cells, 2020
Pregnancy-induced hypertension and preeclampsia are associated with significant maternal and fetal mortality. A better understanding of these diseases, delineation of molecular pathomechanism, and efficient treatment development are some of the most ...
Maciej W. Socha, Bartosz Malinowski, Oskar Puk, Mariusz Dubiel, Michał Wiciński   +4 more
doaj   +1 more source