Results 31 to 40 of about 4,210 (150)

Immunothrombosis and new-onset atrial fibrillation in the general population:: the Rotterdam Study [PDF]

, 2022
Background: Atrial fibrillation (AF) is the most common age-related cardiac arrhythmia. The etiology underlying AF is still largely unknown. At the intersection of the innate immune system and hemostasis, immunothrombosis may be a possible cause of ...
de Maat, Moniek P. M.; id_orcid, Geurts, Sven, de Maat, Moniek P. M., Tilly, Martijn J., Donkel, Samantha J., Kavousi, Maryam, Ikram, M. Arfan, de Groot, Natasja M. S.   +7 more
core   +2 more sources

Alterations in platelet behavior after major trauma: adaptive or maladaptive?

Platelets, 2021
Platelets are damage sentinels of the intravascular compartment, initiating and coordinating the primary response to tissue injury. Severe trauma and hemorrhage induce profound alterations in platelet behavior.
Paul Vulliamy, Lucy Z. Kornblith, Matthew E. Kutcher, Mitchell J. Cohen, Karim Brohi, Matthew D. Neal   +5 more
doaj   +1 more source

Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions.
Jianbo Lou, Jianning Zhang, Quanjun Deng, Xin Chen   +3 more
doaj   +1 more source

Preventing the development of severe COVID-19 by modifying immunothrombosis

, 2021
BACKGROUND: COVID-19-associated acute respiratory distress syndrome (ARDS) is associated with significant morbidity and high levels of mortality. This paper describes the processes involved in the pathophysiology of COVID-19 from the initial infection ...
Berk, M, Puri, BK, Bortolasci, CC, Morris, G, Olive, L, Walder, K, Marx, W, Maes, M, O'Neil, A, Carvalho, A, Athan, E   +10 more
core   +1 more source

Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis [PDF]

, 2021
OBJECTIVE: Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive. DESIGN: We used high-resolution endoscopy and colon tissue samples of active UC (
Hartung, Anne, Schett, Georg, Neufert, Clemens, Stefanie Gößwein, Markus Hoffmann, Christoph Becker, Georg Schett, Scheibe, Kristina, Mascia, Fabrizio, Atreya, Raja, Kühl, Anja A., Bleich, Andre, Christine Schauer, Gonzalez-Acera, Miguel, Martin Herrmann, Vieth, Michael, Kühl, Anja A, Kristina Scheibe, Uderhardt, Stefan, Liebing, Eva, Paulus, Susanne, Gößwein, Stefanie, Patankar, Jay V, Leppkes, Moritz, Anne Hartung, Andre Bleich, Dominik Roth, Sebastian Zundler, Lindemann, Aylin, Zundler, Sebastian, Hoffmann, Markus, Patankar, Jay V., Anja A Kühl, Susanne Paulus, Markus F Neurath, Schauer, Christine, Stefan Uderhardt, Neurath, Markus F., Herrmann, Martin, Miguel Gonzalez-Acera, Roth, Dominik, Clemens Neufert, Neurath, Markus F, Eva Liebing, Becker, Christoph, Raja Atreya, Foersch, Sebastian, Jay V Patankar, Moritz Leppkes, Sebastian Foersch, Michael Vieth, Fabrizio Mascia, Aylin Lindemann   +52 more
core   +1 more source

Programmed neutrophil death in immunothrombosis

RUDN Journal of Medicine
Relevance. Understanding the fundamental mechanisms of immunothrombosis is essential for developing effective treatments and prevention of thrombotic disorders.
Natalya G. Plekhova, Alexander O. Mikhailov, Nikolay V. Tsvetov, Anastasia N. Voronova   +3 more
doaj   +1 more source

Circulating Microvesicles in Association with the NLRP3 Inflammasome in Coronary Thrombi from STEMI Patients

Biomedicines, 2022
Microvesicles (MVs) are actively secreted by cells. The NLRP3-inflammasome and the interleukin 6 (IL-6)-pathways are central in cardiovascular disease. Knowledge of how the inflammasome influences the MVs is limited.
Vibeke Bratseth, Jostein Nordeng, Ragnhild Helseth, Svein Solheim, Sissel Åkra, Harald Arnesen, Gemma Chiva-Blanch, Ingebjørg Seljeflot   +7 more
doaj   +1 more source

Contact Activation Is Alleviated by Testosterone Replacement Therapy in Klinefelter Syndrome: Evidence of Hormonal and Metabolic Modulation

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang, Claus H. Gravholt, Anne Skakkebæk, Anna‐Marie Bloch Münster, Yaseelan Palarasah   +4 more
wiley   +1 more source

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy [PDF]

, 2020
Background: SARS-CoV-2 infection causes severe pneumonia (COVID-19), but the mechanisms of subsequent respiratory failure and complicating renal and myocardial involvement are poorly understood.
Heiko Schulz, Höchter, Dominik J., Michael von Bergwelt-Baildon, Leunig, Alexander, Stephan Ledderose, Ledderose, Stephan, Keppler, Oliver T., Zwißler, Bernhard, Rudelius, Martina, Hellmuth, Johannes C., Martina Rudelius, Konstantin Stark, Nicolai, Leo, Brambs, Sophia, Muenchhoff, Maximilian, Oliver Keppler, Stefan Kääb, Kami Pekayvaz, Rainer Kaiser, Schulz, Heiko, Massberg, Steffen, Dominik Höchter, Steffen Massberg, Stark, Konstantin, Johannes C. Hellmuth, Scherer, Clemens, Bergwelt-Baildon, Michael, Alexander Leunig, Sophia Brambs, Bernhard Zwißler, Leo Nicolai, Daniel Teupser, Michael Weigand, Michael Zoller, Maximilian Muenchhoff, Clemens Scherer, Pekayvaz, Kami, Weigand, Michael, Weinberger, Tobias, Tobias Weinberger, Kaiser, Rainer, Zoller, Michael, Teupser, Daniel, Kääb, Stefan   +43 more
core   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

MedComm, Volume 7, Issue 10, October 2026.
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang, Fangjiaqi Wei, Mengdi Qu, Yuwen Shao, Tingye Xu, Darko Stojkov, Hans‐Uwe Simon, Ben Huang, Changhong Miao, Hao Zhang   +9 more
wiley   +1 more source