Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia
Frontiers in Cell and Developmental Biology, 2023 Background: NETosis occurs in the context of infection or inflammation and results in the expulsion of decondensed DNA filaments called NETs (Neutrophil Extracellular Traps) into the extracellular environment.
Sylvie Bouvier +2 more
exaly +5 more sources
Molecular mechanisms and therapeutic target of NETosis in diseases
MedComm, 2022 Evidence shows that neutrophils can protect the host against pathogens in multiple ways, including the formation and release of neutrophil extracellular traps (NETs).
Weiqi Hong
exaly +3 more sources
NETosis of psoriasis: a critical step in amplifying the inflammatory response
Frontiers in ImmunologyNETosis, a regulated form of neutrophil death, is crucial for host defense against pathogens. However, the release of neutrophil extracellular traps (NETs) during NETosis can have detrimental effects on surrounding tissues and contribute to the pro ...
exaly +4 more sources
De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection [PDF]
Frontiers in ImmunologyBackgroundGlucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop de novo after SARS-CoV-2 infection.
Sergio Sanhueza +32 more
doaj +2 more sources
Bilirubin reduces mortality in sepsis models by inhibiting NOX2-mediated formation of neutrophil extracellular traps [PDF]
Redox ReportObjectives Sepsis is a life-threatening condition driven by a dysregulated immune response to infection, yet therapeutic options beyond antibiotics and vasopressors remain limited.
Sang-Jin Kim +6 more
doaj +2 more sources
Molecular MedicineFollowing cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. They are detected both in brain tissue and within blood vessels.
Sang-A. Oh +4 more
doaj +2 more sources
Study on key markers of NETosis: predictive indicator for postoperative frailty following complete cytoreductive surgery in advanced ovarian cancer [PDF]
Frontiers in ImmunologyObjectiveThis study analyzed factors associated with complete cytoreductive surgery and postoperative frailty in advanced ovarian cancer using key neutrophil extracellular trap (NETosis) markers—neutrophil elastase (NE), myeloperoxidase (MPO), and ...
Xianmei Lu, Feng Xu
doaj +2 more sources
Peptidylarginine deiminase 4 is a differential regulator of salt-sensitive and salt-resistant hypertension [PDF]
iScienceSummary: Neutrophils contribute to immune surveillance by releasing neutrophil extracellular traps (NETs) through NETosis. While essential, dysregulated NETosis is linked to pathology.
Xue Mei +7 more
doaj +2 more sources
Piezo1 expression in neutrophils regulates shear-induced NETosis
Nature CommunicationsNeutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood ...
Sara Baratchi +9 more
doaj +2 more sources
Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis
Kidney DiseasesIntroduction: Neutrophil extracellular traps (NETs) contribute to inflammation and are implicated in autoimmune diseases; however, their role in IgA nephropathy (IgAN) remains unclear. This study aimed to investigate the involvement of NETosis
Gangan Wang +8 more
doaj +2 more sources