Results 1 to 10 of about 12,677 (108)

Molecular mechanisms and therapeutic target of NETosis in diseases

MedComm, 2022
Evidence shows that neutrophils can protect the host against pathogens in multiple ways, including the formation and release of neutrophil extracellular traps (NETs).
Weiqi Hong, Meihua Wan, Limin Zheng
exaly   +2 more sources

Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia

Frontiers in Cell and Developmental Biology, 2023
Background: NETosis occurs in the context of infection or inflammation and results in the expulsion of decondensed DNA filaments called NETs (Neutrophil Extracellular Traps) into the extracellular environment.
Demattei Christophe, Jean-Christophe Gris, Sylvie Bouvier   +2 more
exaly   +3 more sources

<i>De novo</i> COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection. [PDF]

Front Immunol
BackgroundGlucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop de novo after SARS-CoV-2 infection.
Sanhueza S, Cabrera C, Quiroga R, Antilef B, Muñoz C, Vera A, Cartes R, Lamperti L, Guzmán-Gutiérrez E, Aguayo C, Ormazábal V, Hernández MA, Lastra J, Riffo B, Cerda G, Ferrada L, De Gonzalo-Calvo D, García-Hidalgo MC, Henríquez M, Barría MI, Verdugo RA, Colombo A, Labarca G, Nova-Lamperti E.   +23 more
europepmc   +2 more sources

Bilirubin reduces mortality in sepsis models by inhibiting NOX2-mediated formation of neutrophil extracellular traps. [PDF]

Redox Rep
Objectives Sepsis is a life-threatening condition driven by a dysregulated immune response to infection, yet therapeutic options beyond antibiotics and vasopressors remain limited.
Kim SJ, Ko CW, Kim WS, Kang YJ, Lee CH, Lee WW, Park JW.   +6 more
europepmc   +2 more sources

Study on key markers of NETosis: predictive indicator for postoperative frailty following complete cytoreductive surgery in advanced ovarian cancer. [PDF]

Front Immunol
ObjectiveThis study analyzed factors associated with complete cytoreductive surgery and postoperative frailty in advanced ovarian cancer using key neutrophil extracellular trap (NETosis) markers—neutrophil elastase (NE), myeloperoxidase (MPO), and ...
Lu X, Xu F.
europepmc   +2 more sources

Peptidylarginine deiminase 4 is a differential regulator of salt-sensitive and salt-resistant hypertension. [PDF]

iScience
Summary: Neutrophils contribute to immune surveillance by releasing neutrophil extracellular traps (NETs) through NETosis. While essential, dysregulated NETosis is linked to pathology.
Mei X, Saha P, Mell B, Zeydabadinejad S, Yeoh BS, Gohara A, Vijay-Kumar M, Joe B.   +7 more
europepmc   +2 more sources

A semi-automated imaging and analysis pipeline for NET quantification and temporal-profiling of NETosis. [PDF]

Front Immunol
NETosis is a distinct form of neutrophil cell death involved in innate immunity and characterized by the release of DNA, that when dysregulated contributes to tissue damage and target-organ injury.
Landry C, Wang L, Gerber E, Holterman CE, Burger D.   +4 more
europepmc   +2 more sources

Simplified flow cytometric quantification of human neutrophil extracellular traps (NETs). [PDF]

J Inflamm (Lond)
Several cellular pathways lead to the formation of neutrophil extracellular traps (NETs), a form of cell death (NETosis), distinct from apoptotic and necrotic cell death.
Rinaldi G, Cheng KKW, McCann C, Rossi F, Rodriguez-Rios M, Dhaliwal K, Bebes A, Duncan L, Yuecel R, Rossi AG, Robb CT.   +10 more
europepmc   +2 more sources

NETosis of psoriasis: a critical step in amplifying the inflammatory response

Frontiers in Immunology
NETosis, a regulated form of neutrophil death, is crucial for host defense against pathogens. However, the release of neutrophil extracellular traps (NETs) during NETosis can have detrimental effects on surrounding tissues and contribute to the pro ...
Dongmei Shi, Yahui Feng
exaly   +3 more sources

Phytochemicals as potential inhibitors of NETosis: implications for immunothrombosis and chronic disease management. [PDF]

BMC Complement Med Ther
Background NETosis, a specialized form of neutrophil cell death, plays a dual role in immune regulation. While NET formation is essential for capturing pathogens, excessive NETosis contributes to immunothrombosis, oxidative stress, and tissue damage ...
Juanlu C, Chen L, Sung CJ, Hsieh SC.
europepmc   +2 more sources