Results 31 to 40 of about 16,143 (202)

Functional Verification and Prognostic Value of Neutrophil Extracellular Trap-Related Genes in Pancreatic Cancer Progression

Frontiers in Bioscience-Landmark
Background: Pancreatic carcinoma (PC), a severely malignant neoplasm of the digestive system, is characterized by an unfavorable prognosis.
Jiaxin Xu, Liying Tu, Lijing Ma, Qisheng Tang, Yu Cao, Lihong Jiang   +5 more
doaj   +1 more source

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review.

PLoS ONE, 2017
BackgroundMultiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and results, our aim was to create a systematic review of NETosis inducers and perform a ...
Tamara Hoppenbrouwers, Tamara Hoppenbrouwers, Anouchska S A Autar, Andi R Sultan, Tsion E Abraham, Wiggert A van Cappellen, Adriaan B Houtsmuller, Willem J B van Wamel, Heleen M M van Beusekom, Johan W van Neck, Moniek P M de Maat   +10 more
doaj   +1 more source

DataSheet_1_Diverse Roles of NETosis in the Pathogenesis of Lupus.docx

, 2022
NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang (1309134), Ram Raj Singh (12610636), Yupeng Lai (12610630), Tatsuya Ishikawa (285673), Dhiraj Nallapothula (12610633)   +4 more
core   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

NETosis markers: Quest for specific, objective, and quantitative markers [PDF]

, 2016
More than 10 years have passed since the discovery of neutrophil extracellular traps (NETs) in 2004. NETs are extracellular web-like DNA decorated with antimicrobial proteins, which are released from activated neutrophils.
Tomaru, Utano, Nakazawa, Daigo, Kusunoki, Yoshihiro, Masuda, Sakiko, Miyoshi, Arina, Ishizu, Akihiro, Shida, Haruki   +6 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional firing helps to drive NETosis

, 2017
Neutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains an enigma for several decades. Here we show that the transcriptional
Meraj A. Khan, Nades Palaniyar
core   +1 more source

Study on key markers of NETosis: predictive indicator for postoperative frailty following complete cytoreductive surgery in advanced ovarian cancer

Frontiers in Immunology
ObjectiveThis study analyzed factors associated with complete cytoreductive surgery and postoperative frailty in advanced ovarian cancer using key neutrophil extracellular trap (NETosis) markers—neutrophil elastase (NE), myeloperoxidase (MPO), and ...
Xianmei Lu, Feng Xu
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Shear Stress and NETosis [PDF]

Neutrophil granulocytes, the most abundant type of circulating immune cells, engage in a process called NETosis when encountering certain pathogens and danger signals or experimentally induced by phorbol-12-myristate-13-acetate (PMA).
Mrowietz, Lukas Frederik
core   +1 more source