Results 31 to 40 of about 16,413 (245)
Experimental Gerontology, 2023 Neutrophil extracellular trap formation (NETosis) is a mechanism used by neutrophils to capture pathogens with their own DNA. However, the exacerbation of this immune response is related to serious inflammatory diseases.
Nicolás Vidal-Seguel +12 more
doaj +1 more source
Untangling “NETosis” from NETs [PDF]
European Journal of Immunology, 2019 Abstract Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form NETs, neutrophils release a DNA scaffold consisting of mitochondrial DNA binding granule proteins.
Shida Yousefi +6 more
openaire +3 more sources
Journal of Biomedical Science, 2020 Background Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immunity and of Th1 immune responses ...
Patricia Ruiz-Limon +14 more
doaj +1 more source
ROS and DNA repair in spontaneous versus agonist-induced NETosis: Context matters
Frontiers in Immunology, 2022 Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis). Nevertheless, how ROS induces NETosis at baseline and during neutrophil activation is unknown. Although neutrophils carry DNA transcription, replication and
Dhia Azzouz +4 more
doaj +1 more source
Frontiers in Immunology, 2023 Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis), and generated either by NADPH oxidases (e.g., during infections) or mitochondria (e.g., sterile injury) in neutrophils. We recently showed that ultraviolet (
Dhia Azzouz +4 more
doaj +1 more source
ROS induces NETosis by oxidizing DNA and initiating DNA repair
Cell Death Discovery, 2021 Reactive oxygen species (ROS) are essential for neutrophil extracellular trap (NET) formation or NETosis. Nevertheless, how ROS induces NETosis is unknown. Neutrophil activation induces excess ROS production and a meaningless genome-wide transcription to
Dhia Azzouz +2 more
doaj +1 more source
New Insight into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation
Frontiers in Immunology, 2016 Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell death characterized by the release of large web-like structures referred ...
Hang Yang +5 more
doaj +1 more source
Investigation the reasons for varying the severity of COVID-19 from person to person: A review study
Fiyz̤, 2022 Background: COVID-19 is caused by the SARS-COV-2 virus and mainly affects the lung tissue. In addition, other tissues are attacked by the virus. Reports have shown that clinical manifestations in Covid-19 patients vary from asymptomatic to acute ...
Mohsen Rahmani +5 more
doaj
S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis
Nature CommunicationsNeutrophil extracellular traps (NETs) play a critical role in acute myocardial infarction (AMI) and the externalization of S100 family members. Here, we show the effects of S100A12 on NETs formation and myocardial injury following AMI. S100A12 expression
Xi Zhang +10 more
semanticscholar +1 more source
In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review.
PLoS ONE, 2017 BackgroundMultiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and results, our aim was to create a systematic review of NETosis inducers and perform a ...
Tamara Hoppenbrouwers +10 more
doaj +1 more source