Results 51 to 60 of about 16,413 (245)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Frontiers in Immunology, 2021
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4
Patrick Münzer, Patrick Münzer, Patrick Münzer, Patrick Münzer, Roberto Negro, Roberto Negro, Shoichi Fukui, Shoichi Fukui, Lucas di Meglio, Lucas di Meglio, Lucas di Meglio, Karen Aymonnier, Karen Aymonnier, Karen Aymonnier, Long Chu, Long Chu, Deya Cherpokova, Deya Cherpokova, Sarah Gutch, Sarah Gutch, Nicoletta Sorvillo, Nicoletta Sorvillo, Lai Shi, Lai Shi, Venkat Giri Magupalli, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Rüdiger E. Scharf, Rüdiger E. Scharf, Clare M. Waterman, Clare M. Waterman, Hao Wu, Hao Wu, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner   +37 more
doaj   +1 more source

Blocking peptidyl arginine deiminase 4 confers neuroprotective effect in the post-ischemic brain through both NETosis-dependent and -independent mechanisms

Acta Neuropathologica Communications
Peptidylarginine deiminase 4 (PAD4) is an enzyme that modifies proteins by converting positively charged arginine residues to neutral citrulline residues.
Song-I. Seol, S.-A. Oh, Dashdulam Davaanyam, Ja-Kyeong Lee   +3 more
semanticscholar   +1 more source

Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications

Frontiers in Endocrinology, 2023
Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils.
Yuyan Zhu, X. Xia, Qian He, Qingling Xiao, Decheng Wang, Mei-Ying Huang, Xiaolin Zhang   +6 more
semanticscholar   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation

Frontiers in Immunology, 2018
Staphylococcus aureus are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in S. aureus-induced NETosis. We determined the Protein A production of
Tamara Hoppenbrouwers, Tamara Hoppenbrouwers, Andi R. Sultan, Tsion E. Abraham, Nicole A. Lemmens-den Toom, Silvie Hansenová Maňásková, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Willem J. B. van Wamel, Moniek P. M. de Maat, Johan W. van Neck   +10 more
doaj   +1 more source

How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation

Biomolecules
Neutrophil extracellular traps (NETs) are intricate, DNA-based, web-like structures adorned with cytotoxic proteins. They play a crucial role in antimicrobial defense but are also implicated in autoimmune diseases and tissue injury.
Dhia Azzouz, N. Palaniyar
semanticscholar   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis

Efficacy and Mechanism Evaluation
Background Thrombosis with thrombocytopenia syndrome is a rare condition known to occur spontaneously or after heparin use. With the advent of COVID-19 vaccines during the pandemic, thrombosis with thrombocytopenia syndrome cases emerged post ...
Phillip LR Nicolson, Simon T Abrams, Gayatri Amirthalingam, Kevin Brown, Richard J Buka, Mark J Caulfield, Joshua Gardner, David Goldblatt, Charlotte Lovatt, Samantha J Montague, Dean J Naisbitt, Alan Parker, Sue Pavord, Mary E Ramsay, Jonathan AC Sterne, Cathie LM Sudlow, Cheng Hock Toh, Steve P Watson, Guozheng Wang, Angela M Wood, William Whiteley, Munir Pirmohamed   +21 more
doaj   +1 more source

2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation

Journal of Lipid Research, 2018
Neutrophils form neutrophil extracellular traps (NETs), which have been implicated in microcirculatory plugging. NET formation (NETosis) involves the fusion of granule and nuclear contents, which are then released in the extracellular space ...
ElisaN.D. Palladino, Lalage A. Katunga, Grant R. Kolar, David A. Ford   +3 more
doaj   +1 more source