Results 51 to 60 of about 16,143 (202)

2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation

Journal of Lipid Research, 2018
Neutrophils form neutrophil extracellular traps (NETs), which have been implicated in microcirculatory plugging. NET formation (NETosis) involves the fusion of granule and nuclear contents, which are then released in the extracellular space ...
ElisaN.D. Palladino, Lalage A. Katunga, Grant R. Kolar, David A. Ford   +3 more
doaj   +1 more source

Deciphering the role of NETosis-related signatures in the prognosis and immunotherapy of soft-tissue sarcoma using machine learning

Frontiers in Pharmacology, 2023
Background: Soft-tissue sarcomas (STSs) are a rare type of cancer, accounting for about 1% of all adult cancers. Treatments for STSs can be difficult to implement because of their diverse histological and molecular features, which lead to variations in ...
Lin Qi, Lin Qi, Fangyue Chen, Lu Wang, Lu Wang, Zhimin Yang, Zhimin Yang, Zhimin Yang, Wenchao Zhang, Wenchao Zhang, Zhihong Li, Zhihong Li   +11 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases

Научно-практическая ревматология, 2023
Uncontrolled activation of neutrophils is considered an important mechanism of thromboinflammation and fibrosis in immunemediated rheumatic diseases (IMRD), malignant neoplasms, atherosclerosis, COVID-19 and many other acute and chronic inflammatory ...
E. L. Nasonov, A. S. Avdeeva, T. M. Reshetnyak, A. P. Aleksankin, Yu. P. Rubtsov   +4 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

, 2018
Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage.
Scattolini, Valentina, Angelo Avogaro, Albiero, Mattia, Roberta Cappellari, Mario Bortolozzi, Valentina Scattolini, Benedetta Maria Bonora, Filippo Romanato, Cappellari, Roberta, Giulio Ceolotto, Gian Paolo Fadini, Vigili de Kreutzeberg, Saula, Bortolozzi, Mario, Menegazzo, Lisa, Avogaro, Angelo, Lisa Menegazzo, Mattia Albiero, Ceolotto, Giulio, Bonora, Benedetta Maria, Romanato, Filippo, Fadini, Gian Paolo, Saula Vigili de Kreutzeberg   +21 more
core   +1 more source

Netosis as a bridge between inflammation and liver cell injury

Journal of Education, Health and Sport, 2019
One of programmed cell death types, netosis, discovered in ’96, was first described by Zychlinsky et al. and has gained elevating popularity among many researchers. It is a process occurring in order to catch pathogens into a trap and kill them.
Anna Rycyk, Beata Kasztelan-Szczerbinska, Halina Cichoz-Lach   +2 more
doaj  

Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis

Kidney Diseases
Introduction: Neutrophil extracellular traps (NETs) contribute to inflammation and are implicated in autoimmune diseases; however, their role in IgA nephropathy (IgAN) remains unclear. This study aimed to investigate the involvement of NETosis
Gangan Wang, Yixin Dong, Xiangyu Qiao, Chunyu Jia, Jiahui Wang, Gang Chen, Ke Zheng, Chengyu Jiang, Xuemei Li   +8 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source