Results 71 to 80 of about 16,143 (202)

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection

Frontiers in Immunology
BackgroundGlucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop de novo after SARS-CoV-2 infection.
Sergio Sanhueza, Camilo Cabrera, Romina Quiroga, Bárbara Antilef, Camila Muñoz, Camila Muñoz, Agustín Vera, Ricardo Cartes, Ricardo Cartes, Liliana Lamperti, Enrique Guzmán-Gutiérrez, Claudio Aguayo, Valeska Ormazábal, Mauricio Alejandro Hernández, Jaime Lastra, Benilde Riffo, Gustavo Cerda, Luciano Ferrada, David De Gonzalo-Calvo, David De Gonzalo-Calvo, María C. García-Hidalgo, María C. García-Hidalgo, Mario Henríquez, Mario Henríquez, Mario Henríquez, María Inés Barría, Ricardo A. Verdugo, Alicia Colombo, Gonzalo Labarca, Gonzalo Labarca, Gonzalo Labarca, Gonzalo Labarca, Estefanía Nova-Lamperti   +32 more
doaj   +1 more source

A critical reappraisal of neutrophil extracellular traps (NETs) and NETosis mimics based on differential requirements for protein citrullination

Frontiers in Immunology, 2016
NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic lupus erythematosus (SLE).
Maximilian Ferdinand Konig, Felipe Andrade   +1 more
doaj   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Bilirubin reduces mortality in sepsis models by inhibiting NOX2-mediated formation of neutrophil extracellular traps

Redox Report
Objectives Sepsis is a life-threatening condition driven by a dysregulated immune response to infection, yet therapeutic options beyond antibiotics and vasopressors remain limited.
Sang-Jin Kim, Chang Woo Ko, Wan-Seo Kim, Yeon Jun Kang, Chul-Hwan Lee, Won-Woo Lee, Jong-Wan Park   +6 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

NETosis: Molecular Mechanisms, Role in Physiology and Pathology

, 2021
: NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm.
Vorobjeva N.V.
core  

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits [PDF]

, 2019
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil extracellular traps (NETs), are recognized as a physiological microbicidal mechanism of innate immunity.
Maciej Lech (350641), Sarna, Michal, Anna Makarska (6714815), Danuta Bryzek, Danuta Bryzek (6714803), Izabela Ciaston, Anna Gasiorek (6714812), Puklo, Magdalena, Jan Potempa, Joanna Koziel (83263), Anna Gasiorek, Ciastoń, Izabela, Makarska, Anna, Anna Makarska, Magdalena Puklo, Barbara Potempa, Jan Potempa (19854), Michal Sarna, Sigrun Eick (326398), Eick, Sigrun, Lech, Maciej, Bryzek, Danuta, Michal Sarna (697705), Potempa, Jan, Ewelina Dobosz, Pukło, Magdalena, Kozieł, Joanna, Maciej Lech, Potempa, Barbara, Barbara Potempa (6714821), Sigrun Eick, Izabela Ciaston (6714806), Dobosz, Ewelina, Koziel, Joanna, Magdalena Puklo (6714818), Sarna, Michał, Ewelina Dobosz (6714809), Joanna Koziel, Gąsiorek, Anna   +38 more
core   +2 more sources

Netosis contributes to the pathogenesis of diabetes and its complications [PDF]

, 2020
NETosis, a novel form of neutrophil-related cell death, acts as a major regulator of diabetes and diabetes-associated complications. In this review, we show that the extrusion of neutrophil extracellular traps, termed NETs, plays an important role in the
Azar, William S., K̈foury, Hala Kassouf, Eid, Assaad A., Njeim, Rachel, Fares, Angie H., Azar, Sami T.   +5 more
core   +1 more source

Simplified flow cytometric quantification of human neutrophil extracellular traps (NETs)

Journal of Inflammation
Several cellular pathways lead to the formation of neutrophil extracellular traps (NETs), a form of cell death (NETosis), distinct from apoptotic and necrotic cell death.
G. Rinaldi, K. K. W. Cheng, C. McCann, F. Rossi, M. Rodriguez-Rios, K. Dhaliwal, A. Bebes, L. Duncan, R. Yuecel, Adriano G. Rossi, Calum T. Robb   +10 more
doaj   +1 more source