Results 61 to 70 of about 16,143 (202)

Peptidylarginine deiminase 4 is a differential regulator of salt-sensitive and salt-resistant hypertension

iScience
Summary: Neutrophils contribute to immune surveillance by releasing neutrophil extracellular traps (NETs) through NETosis. While essential, dysregulated NETosis is linked to pathology.
Xue Mei, Piu Saha, Blair Mell, Sareh Zeydabadinejad, Beng San Yeoh, Amira Gohara, Matam Vijay-Kumar, Bina Joe   +7 more
doaj   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Untangling "NETosis" from NETs. [PDF]

, 2019
Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu.
Charaf Benarafa, Benarafa, Charaf, Yousefi, Shida, Xiaoliang Wang, Stojkov, Darko, Germic, Nina, Hans‐Uwe Simon, Wang, Xiaoliang, Simon, Hans-Uwe, Darko Stojkov, Shida Yousefi, Dagmar Simon, Simon, Dagmar, Nina Germic   +13 more
core   +1 more source

Phytochemicals as potential inhibitors of NETosis: implications for immunothrombosis and chronic disease management

BMC Complementary Medicine and Therapies
Background NETosis, a specialized form of neutrophil cell death, plays a dual role in immune regulation. While NET formation is essential for capturing pathogens, excessive NETosis contributes to immunothrombosis, oxidative stress, and tissue damage ...
Chen Juanlu, Lihan Chen, Chun-Ju Sung, Shu-Chen Hsieh   +3 more
doaj   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

NETosis and kidney disease: what do we know?

, 2023
Neutrophils are the most abundant leukocytes in the blood. They are rapidly mobilized from the circulation to sites of inflammation and/or infection. In affected tissues, neutrophils exhibit some dramatic antimicrobial functions, including degranulation,
Sena Ulu, Alaygut, Demet, Gungor, Ozkan, Ulu, Sena, Ozkan Gungor, Ozturk, Ilyas, Demet Alaygut, Ilyas Ozturk   +7 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

A perspective on NETosis in diabetes and cardiometabolic disorders

, 2016
Aims: To review the significance of a new type of neutrophil cell death (NETosis) in diabetes and cardiometabolic diseases. Data synthesis: Diabetes and the metabolic syndrome are characterized by activation of the innate immune system.
ALBIERO, MATTIA, SCATTOLINI, VALENTINA, FADINI, GIAN PAOLO, AVOGARO, ANGELO, MENEGAZZO, LISA, GINTOLI, MICHELE   +5 more
core   +1 more source

Gout - asymptomatic hyperuricemia with/without asymptomatic monosodium urate crystal deposition: To be treated or not? [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Elevation of serum uric acid level without clinically visible arthritis (known as asymptomatic hyperuricemia) is not traditionally considered to be gout disease, but only a possible cause of it, even though it may be accompanied by tissue uric acid ...
Radak-Perović Marija, Zlatković-Švenda Mirjana   +1 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source