Results 61 to 70 of about 16,413 (245)

Deciphering the role of NETosis-related signatures in the prognosis and immunotherapy of soft-tissue sarcoma using machine learning

Frontiers in Pharmacology, 2023
Background: Soft-tissue sarcomas (STSs) are a rare type of cancer, accounting for about 1% of all adult cancers. Treatments for STSs can be difficult to implement because of their diverse histological and molecular features, which lead to variations in ...
Lin Qi, Lin Qi, Fangyue Chen, Lu Wang, Lu Wang, Zhimin Yang, Zhimin Yang, Zhimin Yang, Wenchao Zhang, Wenchao Zhang, Zhihong Li, Zhihong Li   +11 more
doaj   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

NETosis in lupus nephritis

Terapevticheskii arkhiv
Aim. To evaluate the levels of MPO-DNA complex in patients with systemic lupus erythematosus (SLE) and its association with the presence of lupus nephritis (LN). Materials and methods. The study included 77 patients with SLE, of whom 30 had SLE without anti phospholipid syndrome (APS), 47 had SLE with APS, and 20 were healthy individuals serving as ...
Tatiana M. Reshetnyak, Kamila S. Nurbaeva, Ivan V. Ptashnik, Anna A. Kudrieva, Alexey A. Belogurov, Aleksander M. Lila, Evgeny L. Nasonov   +6 more
openaire   +3 more sources

Investigating neutrophil cell death in TB pathogenesis [version 1; peer review: 2 approved]

Gates Open Research, 2021
Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs).
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Thumbi Ndung'u, Duran Ramsuran, Mohlopheni J Marakalala, Denelle Moodley, Kimone L Fisher   +6 more
doaj   +1 more source

Neutrophils and NETosis in Alzheimer's disease: Unraveling pathogenic mechanisms and novel therapeutic targets.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central nervous system that causes cognitive decline, memory loss, and neuropsychiatric symptoms.
Sara Chavoshinezhad, Elmira Beirami, E. Izadpanah   +2 more
semanticscholar   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Different Aspects of Netosis

Turkish Bulletin of Hygiene and Experimental Biology, 2017
Autoimmune and autoinflammatory diseases have dramatically increased in both developed and developing countries. The etiology of these diseases is complex and developed due to multifactorial causes. It is tought that autoantigens are the basis of systemic autoimmune diseases in organism.
Neslihan Sürsal, Kader Yıldız
openaire   +3 more sources

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

Nature Communications
Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic
Weiwei Dai, Ruotong Tian, Liubing Yu, Shasha Bian, Yuling Chen, Bowen Yin, Yuxuan Luan, Siqi Chen, Zhuoyang Fan, Rucheng Yan, Xin Pan, Yingyong Hou, Rong Li, Juxiang Chen, Minfeng Shu   +14 more
semanticscholar   +1 more source

Neutrophil Intrinsic And Extrinsic Regulation Of NETosis In Health And Disease

Trends in Microbiology, 2022
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections, and are formed by a web-like structure of DNA that is decorated with anti-microbial effectors.
Valentina Poli, I. Zanoni
semanticscholar   +1 more source