Results 11 to 20 of about 16,143 (202)

Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis

Frontiers in Medicine, 2018
Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H+ ions reducing the intracellular pH
Meraj A. Khan, Meraj A. Khan, Lijy M. Philip, Guillaume Cheung, Shawn Vadakepeedika, Hartmut Grasemann, Hartmut Grasemann, Hartmut Grasemann, Neil Sweezey, Neil Sweezey, Neil Sweezey, Neil Sweezey, Nades Palaniyar, Nades Palaniyar, Nades Palaniyar, Nades Palaniyar   +15 more
doaj   +3 more sources

Diverse Roles of NETosis in the Pathogenesis of Lupus [PDF]

Frontiers in Immunology, 2022
NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang, Meiying Wang, Tatsuya Ishikawa, Yupeng Lai, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +8 more
doaj   +2 more sources

Heterotypic intercellular interactions as regulators of NETosis [PDF]

Frontiers in Immunology, 2016
Neutrophil extracellular traps (NETs) are chromatin-derived webs extruded from neutrophils in response to either infection or sterile stimulation with chemicals, cytokines, or microbial products.
Nayef M. Kazzaz, Gautam Sule, Jason S. Knight   +2 more
doaj   +2 more sources

NETosis of psoriasis: a critical step in amplifying the inflammatory response [PDF]

Frontiers in Immunology
NETosis, a regulated form of neutrophil death, is crucial for host defense against pathogens. However, the release of neutrophil extracellular traps (NETs) during NETosis can have detrimental effects on surrounding tissues and contribute to the pro ...
Jinke Zhang, Yahui Feng, Dongmei Shi, Dongmei Shi   +3 more
doaj   +2 more sources

Piezo1 expression in neutrophils regulates shear-induced NETosis

Nature Communications
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood ...
Sara Baratchi, Habiba Danish, Chanly Chheang, Ying Zhou, Angela Huang, Austin Lai, Manijeh Khanmohammadi, Kylie M. Quinn, Khashayar Khoshmanesh, Karlheinz Peter   +9 more
doaj   +2 more sources

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture-Induced Sepsis and the Ameliorating Effects of Adipose-Derived Stem Cell Exosomes. [PDF]

Kaohsiung J Med Sci
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Wu SC, Lu TH, Wu YC, Lin CW, Tsai CW, Hsieh CH.   +5 more
europepmc   +2 more sources

MMP8 Promotes NETosis in Gestational Diabetes Mellitus. [PDF]

Antioxidants (Basel)
Background: Neutrophil extracellular traps (NETs) have been known to be involved in the gestational diabetes mellitus (GDM), but the underlying role remains poorly understood. Methods: We conducted an integrated analysis of bulk RNA-seq data, single-cell
Li N, Zhou T, Yang K, Yang WJ, Yang G, Duan YW, Yang Y, Liu HY, Liu SM.   +8 more
europepmc   +2 more sources

GnRH impairs diabetic wound healing through enhanced NETosis [PDF]

, 2020
It has been reported that neutrophil extracellular traps (NETs) impair wound healing in diabetes and that inhibiting NET generation (NETosis) improves wound healing in diabetic mice.
Kim, HJ, Park, YU, Han, CH, Lee, YS, Kang, SU, Kim, CH, Lee, MH, Won, HR   +7 more
core   +1 more source

Machine Learning to Quantitate Neutrophil NETosis [PDF]

, 2019
We introduce machine learning (ML) to perform classifcation and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate ...
Ramadan, N., Holly, S. P., Metts, Carrington A., Ataga, K. I., Modasshir, M., Holly, Stephen P., Cowles, Martis W., Parise, Leslie V., Rekleitis, Ioannis, Rekleitis, I., Burris, Christine A., Ataga, Kenneth I., Elsherif, L., Walker, J. A., Leisner, T. L., Walker, Joshua A., Ramadan, Nadeem, Modasshir, Md., Cowles, M., Elsherif, Laila, Sciaky, Noah, Parise, L. V., Sciaky, N., Cooper, J. N., Cooper, Joshua N., Burris, C. A., Leisner, Tina M., Metts, C. A.   +27 more
core   +1 more source

RGS16 Aggravates Hepatic Ischemia-Reperfusion Injury via Hepatocyte-Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis. [PDF]

Adv Sci (Weinh)
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Li X, Meng Z, Yu H, Hua Y, Li Z, Yin B, Qian B, Li Z, Zhou Y, Feng Z, Lu S, Ke S, Bai M, Fu Y, Tang W, Belosludtseva NV, Ma Y.   +16 more
europepmc   +2 more sources