Results 11 to 20 of about 16,413 (245)
Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis [PDF]
Frontiers in Medicine, 2018 Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H+ ions reducing the intracellular pH
Nades Palaniyar +2 more
exaly +7 more sources
Cellular Mechanisms of NETosis [PDF]
Annual Review of Cell and Developmental Biology, 2020 Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil ...
H. Thiam +3 more
semanticscholar +3 more sources
NETosis: Molecular Mechanisms, Role in Physiology and Pathology
Biochemistry (Moscow), 2020 NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm.
Boris Chernyak, Chernyak B V
exaly +2 more sources
A semi-automated imaging and analysis pipeline for NET quantification and temporal-profiling of NETosis [PDF]
Frontiers in ImmunologyNETosis is a distinct form of neutrophil cell death involved in innate immunity and characterized by the release of DNA, that when dysregulated contributes to tissue damage and target-organ injury.
Chloé Landry +8 more
doaj +2 more sources
International Journal of NanomedicineLingping Tan,1,2,* Chi Zhang,1,2,* Xiaoxing Kou,1– 3 Lu Zhao,4 Di Wu,1– 3 Jinyu Li,1,2 Chuanying Yu,1,2 Tansi Xu,1,2 Li Gao,1,2 Xueli Mao,1– 3 Chuanjiang Zhao1,2 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University ...
Tan L +10 more
doaj +2 more sources
Diverse Roles of NETosis in the Pathogenesis of Lupus
Frontiers in Immunology, 2022 NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang +8 more
doaj +5 more sources
Simplified flow cytometric quantification of human neutrophil extracellular traps (NETs) [PDF]
Journal of InflammationSeveral cellular pathways lead to the formation of neutrophil extracellular traps (NETs), a form of cell death (NETosis), distinct from apoptotic and necrotic cell death.
G. Rinaldi +10 more
doaj +2 more sources
Phytochemicals as potential inhibitors of NETosis: implications for immunothrombosis and chronic disease management [PDF]
BMC Complementary Medicine and TherapiesBackground NETosis, a specialized form of neutrophil cell death, plays a dual role in immune regulation. While NET formation is essential for capturing pathogens, excessive NETosis contributes to immunothrombosis, oxidative stress, and tissue damage ...
Chen Juanlu +3 more
doaj +2 more sources
Heterotypic intercellular interactions as regulators of NETosis [PDF]
Frontiers in Immunology, 2016 Neutrophil extracellular traps (NETs) are chromatin-derived webs extruded from neutrophils in response to either infection or sterile stimulation with chemicals, cytokines, or microbial products.
Nayef M. Kazzaz +2 more
doaj +3 more sources
Annals of SurgeryObjective: To provide surgeons with an understanding of the latest research on NETosis, including the pathophysiology and treatment of conditions involving neutrophil extracellular traps (NETs) in the care of surgical patients.
P. James +2 more
semanticscholar +3 more sources