Results 21 to 30 of about 16,413 (245)
Scavenging of Isolevuglandins Attenuates Neutrophil Migration and Neutrophil Extracellular Trap Formation in Systemic Lupus Erythematosus [PDF]
ACR Open RheumatologyObjective Systemic lupus erythematosus (SLE) is an autoimmune disease that affects numerous organs. Neutrophil extracellular traps (NETs) contribute to sterile inflammation and autoantibody generation in SLE.
Jaya Krishnan +7 more
doaj +2 more sources
Autoimmune Diseases, 2013 Neutrophils are the first line of defense of the immune system against infection. Among their weaponry, they have the ability to mix and extrude their DNA and bactericidal molecules creating NET-like structures in a unique type of cell death called NETosis.
Mesa, Miguel Antonio, Vasquez, Gloria
+5 more sources
PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury [PDF]
Advanced ScienceMyocardial ischemia‐reperfusion (MI/R) injury remains a critical challenge in cardiovascular therapeutics, with metabolic‐inflammatory signaling axis emerging as a critical mediator of pathological outcomes. Yet, the specific metabolic pathways interplay
Jiawei Wu +11 more
doaj +2 more sources
Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus
Современная ревматология, 2021 Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease.
K. S. Nurbaeva +2 more
doaj +1 more source
NETosis in Alzheimer’s Disease [PDF]
Frontiers in Immunology, 2017 Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses.
Pietronigro, Enrica Caterina +3 more
openaire +3 more sources
Receptor-Mediated NETosis on Neutrophils [PDF]
Frontiers in Immunology, 2021 Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection. The specific engagement of cell-surface receptors by extracellular signaling molecules activates diverse intracellular signaling cascades and regulates ...
Tao Chen +19 more
openaire +3 more sources
Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation
Frontiers in Immunology, 2019 Neutrophils are the most abundant type of white blood cells. Upon stimulation, they are able to decondense and release their chromatin as neutrophil extracellular traps (NETs). This process (NETosis) is part of immune defense mechanisms but also plays an
Luise Erpenbeck +12 more
doaj +1 more source
Oncoscience, 2015 A large proportion of cancer-related deaths are caused by thrombosis and general organ failure. Although the awareness of tumor-induced systemic effects has increased significantly in recent years, current knowledge is still mainly restricted to metastatic sites.
Jessica, Cedervall, Anna-Karin, Olsson
openaire +2 more sources
Histone Acetylation Promotes Neutrophil Extracellular Trap Formation
Biomolecules, 2019 Neutrophils undergo a unique form of cell death to generate neutrophil extracellular traps (NETs). It is well established that citrullination of histones (e.g., CitH3) facilitates chromatin decondensation during NET formation (NETosis), particularly ...
Hussein J. Hamam +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis. Hypertonic saline is administered to treat many inflammatory diseases, including cystic fibrosis.
Ajantha Nadesalingam +5 more
doaj +1 more source