Results 21 to 30 of about 12,736 (166)

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy. [PDF]

MedComm (2020)
Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Ma Z, Wang Q, Zhang Y, Li Y, Wu H, Yang H, Li X.   +6 more
europepmc   +2 more sources

Diverse Roles of NETosis in the Pathogenesis of Lupus

Frontiers in Immunology, 2022
NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang, Meiying Wang, Tatsuya Ishikawa, Yupeng Lai, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +8 more
doaj   +1 more source

ROS induces NETosis by oxidizing DNA and initiating DNA repair

Cell Death Discovery, 2021
Reactive oxygen species (ROS) are essential for neutrophil extracellular trap (NET) formation or NETosis. Nevertheless, how ROS induces NETosis is unknown. Neutrophil activation induces excess ROS production and a meaningless genome-wide transcription to
Dhia Azzouz, Meraj A. Khan, Nades Palaniyar   +2 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Investigation the reasons for varying the severity of COVID-19 from person to person: A review study

Fiyz̤, 2022
Background: COVID-19 is caused by the SARS-COV-2 virus and mainly affects the lung tissue. In addition, other tissues are attacked by the virus. Reports have shown that clinical manifestations in Covid-19 patients vary from asymptomatic to acute ...
Mohsen Rahmani, Bahare Nikoozar , Mahboobeh Golchin, Marziyeh Tavalaee , Mehdi Hajian , Mohammad Hossein Nasr-Esfahani   +5 more
doaj  

Influences of chloride and hypochlorite on neutrophil extracellular trap formation. [PDF]

PLoS ONE, 2012
The release by neutrophils of DNA-based extracellular traps (NETs) is a recently recognized innate immune phenomenon that contributes significantly to control of bacterial pathogens at tissue foci of infection.
Kathryn Akong-Moore, Ohn A Chow, Maren von Köckritz-Blickwede, Victor Nizet   +3 more
doaj   +1 more source

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review.

PLoS ONE, 2017
BackgroundMultiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and results, our aim was to create a systematic review of NETosis inducers and perform a ...
Tamara Hoppenbrouwers, Tamara Hoppenbrouwers, Anouchska S A Autar, Andi R Sultan, Tsion E Abraham, Wiggert A van Cappellen, Adriaan B Houtsmuller, Willem J B van Wamel, Heleen M M van Beusekom, Johan W van Neck, Moniek P M de Maat   +10 more
doaj   +1 more source

New Insight into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

Frontiers in Immunology, 2016
Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell death characterized by the release of large web-like structures referred ...
Hang Yang, Mona Helena Biermann, Jan Markus Brauner, Yi Liu, Yi Zhao, Martin Herrmann   +5 more
doaj   +1 more source

Functional Verification and Prognostic Value of Neutrophil Extracellular Trap-Related Genes in Pancreatic Cancer Progression

Frontiers in Bioscience-Landmark
Background: Pancreatic carcinoma (PC), a severely malignant neoplasm of the digestive system, is characterized by an unfavorable prognosis.
Jiaxin Xu, Liying Tu, Lijing Ma, Qisheng Tang, Yu Cao, Lihong Jiang   +5 more
doaj   +1 more source

Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils

Biomolecules, 2018
Various biomolecules induce neutrophil extracellular trap (NET) formation or NETosis. However, the effect of fatty acids on NETosis has not been clearly established. In this study, we focused on the NETosis-inducing ability of several lipid molecules. We
Meraj A. Khan, Cecil Pace-Asciak, Jassim M. Al-Hassan, Mohammad Afzal, Yuan Fang Liu, Sosamma Oommen, Bincy M. Paul, Divya Nair, Nades Palaniyar   +8 more
doaj   +1 more source