Results 51 to 60 of about 4,210 (150)
Interaction between beta2 integrin and thrombomodulin effect to immunothrombosis [PDF]
, 2018 application/pdf敗血症では炎症と凝固のクロストーク、いわゆる免疫反応による凝固障害（Immunothrombosis）が注目されている。これらは細菌の体内での広がりを抑制するための生体反応と考えられているが、その生成過程で血管内皮と白血球がどのように相互作用しているか不明な点が多い。我々はImmunothrombosisの病態解明のためにTMの炎症時と非炎症時の発現量をフローサイトメトリーと免疫染色により確認し、さらに白血球と血管内皮細胞との結合実験系を確立した ...
川本, 英嗣 +2 more
core +1 more source
Frontiers in Immunology, 2022 During the COVID-19 pandemic, vaccination is the most important countermeasure. Pharmacovigilance concerns however emerged with very rare, but potentially disastrous thrombotic complications following vaccination with ChAdOx1.
Nicole de Buhr +28 more
doaj +1 more source
, 2023 Immunothrombosis-immune-mediated activation of coagulation-is protective against pathogens, but excessive immunothrombosis can result in pathological thrombosis and multiorgan damage, as in severe coronavirus disease 2019 (COVID-19).
Di Nisio M. +8 more
core +1 more source
Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation
Frontiers in Surgery, 2022 Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies prioritized transmissibility-based precautions and hospital capacity as the foundation for delay of elective procedures.
Connor M. Bunch +39 more
doaj +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, Volume 13, Issue 47, 24 August 2026.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley +1 more source
An Italian cartography of VEXAS‐related thrombosis
HemaSphere, Volume 10, Issue 8, August 2026.Abstract Thrombotic events (TEs) occur in up to 40% of patients with vacuoles, E1 enzyme, X‐linked, autoinflammatory, and somatic (VEXAS) syndrome, but data on its clinical‐genomics features and anticoagulation strategies are limited. To gain more insight into this, we conducted a two‐step study evaluating the prevalence and outcome of TE in VEXAS ...
Giorgia Ranucci +42 more
wiley +1 more source
Evolutionary Insight into Immunothrombosis as a Healing Mechanism
, 2022 Both invertebrates and vertebrates possess a cluster of immediate and local wound-sealing, pathogen-killing, and tissue healing responses known as immunoclotting and immunothrombosis, respectively, to cope with two life-threatening emergencies, namely ...
Eduardo Anitua +5 more
core +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background Long‐term cardiovascular complications after COVID‐19 are increasingly recognized, yet the protective effect of pre‐infection vaccination in individuals without prior cardiovascular disease (CVD) remains unclear. This study examined the association between COVID‐19 vaccination and major cardiovascular and related outcomes up to 3 ...
Abdul Qadeer +11 more
wiley +1 more source
Thrombomodulin as a Physiological Modulator of Intravascular Injury
Frontiers in Immunology, 2020 Thrombomodulin (TM), which is predominantly expressed on the endothelium, plays an important role in maintaining vascular homeostasis by regulating the coagulation system. Intravascular injury and inflammation are complicated physiological processes that
Kanako Watanabe-Kusunoki +3 more
doaj +1 more source