Results 71 to 80 of about 4,210 (150)

The Microvascular–Immune Interface in Cardiovascular Disease: A Stage-Based Framework of Microvascular Failure

Hearts
Cardiovascular disease is traditionally interpreted through macrocirculatory parameters such as cardiac output, vascular resistance, and epicardial coronary anatomy.
Jathniel Panneflek, Béatrice Lauzea, Mahmoud Barbarawi, Atari Greenaway   +3 more
doaj   +1 more source

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

, 2021
Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe disease show hyperactivation of the immune system, which can affect multiple organs ...
Van Tassell, Benjamin W., Dentali, Francesco, Fabrizio Montecucco, Levi, Marcel, Lorenzo Dagna, Van Tassell, Benjamin W, Antonio Abbate, Vecchie, Alessandra, Dixon, Dave L, Dagna L., Abbate A., Marcel Levi, Van Tassell B. W., Dixon, Dave L., Martinod, Kimberly, Bonaventura, Aldo, Alessandra Vecchié, Massberg, Steffen, Bonaventura A., Steffen Massberg, Abbate, Antonio, Dagna, Lorenzo, Aldo Bonaventura, Montecucco, Fabrizio, Kimberly Martinod, Francesco Dentali, Benjamin W. Van Tassell, Vecchie A., Dentali F., Montecucco F., Levi M., Dave L. Dixon, Dixon D. L., Massberg S., Martinod K.   +34 more
core   +1 more source

Platelet hyperresponsiveness and increased platelet‐neutrophil aggregates in dogs with myxomatous mitral valve disease and pulmonary hypertension

Journal of Veterinary Internal Medicine
Background Pulmonary hypertension (PH) in dogs with myxomatous mitral valve disease (MMVD) is caused by increased pulmonary venous pressure. Thrombosis, vascular remodeling, and vasoconstriction mediated by platelets could exacerbate PH.
Laetitia Duler, Lance Visser, Nghi Nguyen, Lynelle R. Johnson, Joshua A. Stern, Ronald H. L. Li   +5 more
doaj   +1 more source

Mast Cells in Acute COVID‐19 Patients

Allergy, Volume 81, Issue 8, Page 2984-2989, August 2026.
Ilan Zaffran, Hadas Pahima, Eli Ben‐Chetrit, Amir Jarjoui, Ilaria Puxeddu, Carl Zinner, Joana Vitte, Alexandar Tzankov, Francesca Levi‐Schaffer   +8 more
wiley   +1 more source

Revisiting sepsis-induced coagulopathy: limitations of current diagnostic tools and the dawn of targeted therapies

陆军军医大学学报
Coagulation disorders constitute a core pathological event in sepsis, and the progression of sepsis-induced coagulopathy (SIC) to disseminated intravascular coagulation (DIC) is a major driver of multi-organ failure and death in septic patients.
Wang Gang
doaj   +1 more source

Hyperinflammation and Derangement of Renin-Angiotensin-Aldosterone System in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis

, 2020
Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome virus coronavirus 2 (SARS-CoV-2), are frequently characterized by hyperinflammation, imbalance of renin-angiotensin-
Michael Henry, Brandon, Benoit, Stefanie, Favaloro, Emmanuel J, Vikse, Jens, Lippi, Giuseppe   +4 more
core   +1 more source

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

, 2020
COVID-19 affects millions of patients worldwide with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support.
Borczuk, A., Iovino, A, Baxter-Stoltzfus, A., Rondina, MT, Manne, BK, Con Yost, C, Mostyka, M, Petrey, AC, Egeblad, M., Denorme, F, Loda, M., Portier, I, He, X.-Y., Beswick, EJ, Middleton, EA, Ng, D., Salvatore, S., Campbell, RA, Weyrich, AS, Harris, E, Caulin, AF, Schiffman, JD, Cody, MJ, Abegglen, LM   +23 more
core   +1 more source

NLRP3 Marks an Inflammatory Neutrophil–NETosis–Pyroptosis Network in Human Ischemic Stroke Thrombi

Cells
Background: Human ischemic stroke thrombi are increasingly recognized as biologically active immunothrombotic structures. While the NLRP3 inflammasome contributes to experimental stroke pathology, its role within human cerebral thrombi remains poorly ...
Maximilian Bellut, Milena Strootmann, Fabian Essig, Guido Stoll, Marius L. Vogt, Konstanze Guggenberger, Mirko Pham, Alexander M. Kollikowski, Michael K. Schuhmann   +8 more
doaj   +1 more source

Issue Information

Rheumatology &Autoimmunity, Volume 6, Issue 3, September 2026.
wiley   +1 more source

Microrheological aspects of severe COVID-19: relationship with anticoagulant therapy and possible disorders of the Fåhræus-Lindqvist effect

Медицина неотложных состояний
Background. Severe COVID-19 is characterized by endothelial dysfunction, immunothrombosis, and microvascular coagulopathy, which play a pivotal role in the development of multiple organ failure and increased mortality.
O.M. Mazur, R.O. Tkachenko
doaj   +1 more source