Results 81 to 90 of about 4,210 (150)

Understanding COVID-19-associated endothelial dysfunction: role of PIEZO1 as a potential therapeutic target

Frontiers in Immunology
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Due to its high infectivity, the pandemic has rapidly spread and become a global health crisis.
Xiaoting Zhang, Jinhai Liu, Xiaoming Deng, Lulong Bo   +3 more
doaj   +1 more source

Immunothrombosis in severe COVID-19

EBioMedicine, 2020
Daigo Nakazawa, Akihiro Ishizu
doaj   +1 more source

Early Diagnostic Markers and Risk Stratification in Sepsis: Prognostic Value of Neutrophil-to-Lymphocyte Ratio, Platelets, and the Carmeli Score

Biomedicines
Background/Objectives: Sepsis is characterized by a dysregulated host response to infection, where immune-inflammatory and thrombo-inflammation drive organ dysfunction. Early recognition of high-risk patients is essential.
Mircea Stoian, Leonard Azamfirei, Andrei Claudiu Stîngaciu, Lorena-Maria Negulici, Anca Meda Văsieșiu, Andrei Manea, Adina Stoian   +6 more
doaj   +1 more source

Immunothrombosis in Severe COVID-19 and Bacterial Sepsis, and Barriers to Biosampling-Based Translational Research

Infection, immunity, and blood coagulation are interconnected through a process known as immunothrombosis. In cases of serious illness, such as severe COVID-19 or bacterial sepsis (life-threatening organ dysfunction caused by dysregulated host response ...
Cani, Erblin
core   +1 more source

Immunothrombosis in Sepsis: Cellular Crosstalk, Molecular Triggers, and Therapeutic Opportunities—A Review

Sepsis remains a critical global health challenge characterized by life-threatening organ dysfunction arising from a dysregulated host response to infection.
Michael Siu-Lun Lai, Zhiwei Jiang, Addis Aklilu, Shea Ping Yip, Chien-Ling Huang   +4 more
core   +1 more source

COVID-19 and systemic thrombotic syndromes

Акушерство, гинекология и репродукция
COVID-19 is one of the most dangerous diseases of the current decade that has significantly affected the overall morbidity, mortality, quality of health and life of global population.
A. D. Makatsariya
doaj   +1 more source

Augmentation of immunothrombosis as a key mechanism underlying JAK inhibition associated hypercoagulability in rheumatoid arthritis

Objectives Venous thromboembolism (VTE), following Janus kinase inhibitors treatment (JAKi), is poorly understood in rheumatoid arthritis (RA). We investigated whether JAKi augmented immune cell-driven clotting or immunothrombosis in RA. Methods
McGonagle, D., Macleod, T., Shi, Y., Ganguly, P., David, P., Altaie, A., Giryes, S., Scarsbrook, A., Duval, C., Saleem, B., Di Matteo, A., Mankia, K., Ariëns, R., Santos, G.D.M., Emery, P., Harland, M., Wong, C., Dass, S., Abacar, K.   +18 more
core   +1 more source

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

, 2017
Acute respiratory distress syndrome (ARDS) is defined as a syndrome of acute onset, with bilateral opacities on chest imaging and respiratory failure not caused by cardiac failure, leading to mild, moderate, or severe oxygenation impairment. The syndrome
Frantzeskaki, F., Armaganidis, A., Orfanos, S.E.   +2 more
core   +1 more source

The concept of immunothrombosis in pancreas transplantation

Early failure of a pancreatic allograft due to complete thrombosis has an incidence of approximately 10% and is the main cause of comorbidity in pancreas transplantation. Although several risk factors have been identified, the exact mechanisms leading to
Ternisien, Catherine, Branchereau, Julien, Mesnard, Benoit, Cantarovich, Diego, Masset, Christophe, TREPID Group, Degauque, Nicolas, Dantal, Jacques, Blancho, Gilles, Brouard, Sophie, Drillaud, Nicolas, Bruneau, Sarah, Gerard, Nathalie, Giral, Magali   +13 more
core   +1 more source

Studies of Heparin Variants in Sepsis-Associated Immunothrombosis

Sepsis is a life-threatening disease characterized by a dysregulated host response to infection, often leading to shock, organ failure, and death. It remains a global emergency, causing 6 to 8 million deaths annually.
Khan, Zarafshan
core   +1 more source