Results 41 to 50 of about 4,210 (150)

Neutrophil extracellular traps as markers of thromboinflammation in the pathogenesis of female genital tract and breast malignant neoplasms

open access: yesАкушерство, гинекология и репродукция, 2022
Introduction. Thrombosis is a formidable complication of the oncological process that still profoundly contributes to overall mortality despite the anticoagulant use.
E. V. Slukhanchuk   +6 more
doaj   +1 more source

Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses

open access: yesThe FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Chronic kidney disease (CKD) is characterized by persistent inflammation that drives progressive renal injury and fibrosis. In this study, we demonstrate that disulfiram markedly attenuates kidney injury and fibrosis in adenine‐induced nephropathy by suppressing innate immune responses and reducing DNA damage and cellular senescence.
Saori Kin   +5 more
wiley   +1 more source

Platelet‐leukocyte interactions in COVID‐19: Contributions to hypercoagulability, inflammation, and disease severity

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2022
A State of the Art lecture titled “Platelet‐leukocyte interactions in COVID‐19: Contributions to hypercoagulability, inflammation and disease severity” was presented at the International Society for Thrombosis and Hemostasis (ISTH) congress in 2021 ...
Eugenio D. Hottz, Patrícia T. Bozza
doaj   +1 more source

High Proportion of PNH Type II Neutrophils Is Associated With Thrombosis in Patients Displaying a PNH Clone ≥ 1%

open access: yesAmerican Journal of Hematology, Volume 101, Issue 9, Page 2311-2328, September 2026.
ABSTRACT The clinical significance of PNH Type II white blood cells (WBCs) remains unclear. We assessed the relative percentage (rel%) of Type II neutrophils in 355 patients with a PNH clone ≥ 1% on neutrophils enrolled by 33 flow cytometry laboratories in the 5‐year French nation‐wide multicenter prospective observational study.
Orianne Wagner‐Ballon   +41 more
wiley   +1 more source

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection [PDF]

open access: yes, 2021
Herein, we consider venous immunothrombotic mechanisms in SARS-CoV-2 infection and anti-SARS-CoV-2 DNA vaccination. Primary SARS-CoV-2 infection with systemic viral RNA release (RNAaemia) contributes to innate immune coagulation cascade activation, with ...
Bridgewood, C, De Marco, G, McGonagle, D
core   +1 more source

Role and intervention of PAD4 in NETs in acute respiratory distress syndrome

open access: yesRespiratory Research
Background Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Acute respiratory distress syndrome (ARDS) is a common sepsis-associated injury that can increase postoperative mortality but the mechanism is ...
Xiaojie Liu   +4 more
doaj   +1 more source

Toward Individualized Atherosclerosis Therapy: Clinical Endotypes, Programmable Therapeutics, and Delivery Constraints

open access: yesMedicine Bulletin, Volume 2, Issue 4, Page 388-405, September 2026.
ABSTRACT Atherosclerosis remains the dominant substrate of atherosclerotic cardiovascular disease (ASCVD), yet recurrent events persist even when LDL cholesterol is driven to guideline targets, underscoring residual risk as a central limitation of contemporary prevention.
Yundong Peng   +8 more
wiley   +1 more source

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
BackgroundPatients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported.
Hao Zhang   +16 more
doaj   +1 more source

he effects of NETosis on fibrinolysis in colon cancer patients

open access: yesБюллетень сибирской медицины, 2022
Aim. To investigate formation of neutrophil extracellular traps (NETs) and their impact on fibrinolysis in patients with colon cancer.Materials and methods. The study was performed in two groups.
A. A. Parshina   +4 more
doaj   +1 more source

Immunomodulatory Nanozymes as Programmable Redox–Immune Set‐Point Regulators

open access: yesSmall, Volume 22, Issue 53, 21 September 2026.
Conceptual phase space linking reactive oxygen species level/dynamics to immune state, with pathological set‐points for chronic inflammation, tumor escape, and degeneration contrasted against a central healthy redox–immune set‐point. Buffering and amplifying nanozymes are depicted as devices that dial redox tone up or down to steer diseased ...
Sumi Choi   +3 more
wiley   +1 more source

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