Results 51 to 60 of about 10,571 (202)

Outcomes With Finerenone by Baseline Treatment Goals in Type 2 Diabetes and Chronic Kidney Disease: A FIDELITY Analysis

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The American Diabetes Association recommends achieving treatment goals (glycated haemoglobin ≤ 53 mmol/mol [7.0%], blood pressure < 130/80 mmHg, low‐density lipoprotein cholesterol < 1.81 mmol/L and use of sodium–glucose cotransporter‐2 inhibitors or glucagon‐like peptide‐1 receptor agonists), to reduce cardiovascular and kidney ...
João Sérgio Neves   +12 more
wiley   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner   +10 more
wiley   +1 more source

Coming out of the cold: Vanadium is an important player in N‐fixation in warm tropical environments

open access: yesEcology, Volume 107, Issue 4, April 2026.
Abstract Nitrogen (N)‐fixation is a crucial source of reactive N in terrestrial environments. The nitrogenase enzyme (Nase), responsible for this conversion, has three isoforms: molybdenum (Mo)‐, vanadium (V)‐, and iron (Fe)‐Nases. The Mo‐Nase is found in all N‐fixers, but the distribution pattern and drivers of V‐ and Fe‐Nases remain poorly understood.
Ana Fávaro   +4 more
wiley   +1 more source

GLP‐1 Receptor Agonists for the Prevention of New‐Onset Heart Failure: A Systematic Review and Meta‐Analysis of Placebo‐Controlled Randomized Clinical Trials

open access: yesObesity Reviews, Volume 27, Issue 4, April 2026.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) improve outcomes in heart failure (HF) with preserved ejection fraction. Whether GLP‐1 RA prevent new‐onset HF in Type 2 diabetes or obesity requires further investigation. Methods We performed an updated meta‐analysis of randomized placebo‐controlled trials (RCT) of treatment ...
João Sérgio Neves   +8 more
wiley   +1 more source

Strategic Key Performance Indicators for AI in Lead Optimization

open access: yesChemMedChem, Volume 21, Issue 6, 27 March 2026.
As AI becomes an integral assistant in lead optimization, measuring its true value requires a shift from technical metrics to strategic key performance indicators (KPIs). This perspective from the EFMC2 initiative recommends specific, impact‐oriented KPIs to objectively assess how digital tools enhance decision‐making and impact top‐line results.
Theodor Theis   +7 more
wiley   +1 more source

Leveraging Change: Perceived Relevance and Organisational Support for Agents of Change for Sustainable Land Management in Agriculture in Aotearoa New Zealand

open access: yesKōtuitui: New Zealand Journal of Social Sciences Online, Volume 21, Issue 1, March 2026.
This study examines the role of agents of change (AoCs) in promoting environmentally sustainable land management in Aotearoa New Zealand's (AoNZ's) agricultural system. Survey responses from 196 individuals across five organisational types highlighted significant sustainability challenges in nine agricultural sectors.
Bruce Small   +9 more
wiley   +1 more source

Service Function Chain Update and Buffer Scheduling Model With State Consistency

open access: yesIEEE Open Journal of the Communications Society
A service function chain (SFC) is a set of virtualized network functions (VNFs) concatenated in a virtualized network. Paths of SFCs need to be updated to achieve load balancing and security.
Reo Uneyama, Takehiro Sato, Eiji Oki
doaj   +1 more source

VNF Chain Placement for Large Scale IoT of Intelligent Transportation

open access: yesSensors, 2020
With the advent of the Internet of things (IoT), intelligent transportation has evolved over time to improve traffic safety and efficiency as well as to reduce congestion and environmental pollution.
Xing Wu   +4 more
doaj   +1 more source

VNF modeling towards the cloud-RAN implementation

open access: yes2017 International Conference on Networked Systems (NetSys), 2017
—We address in this paper the problem of modeling Virtual Network Functions (VNFs) in order to devise execution principles. We specifically represent a VNF as a chain of sub-functions or micro-services and investigate its processing on a multi-core platform. Instead of reserving dedicated resources to a VNF, we specifically examine the gain that can be
Quintuna Rodriguez, Veronica Karina   +1 more
openaire   +2 more sources

Dynamic Hardware-Acceleration of VNFs in NFV Environments [PDF]

open access: yes2019 Sixth International Conference on Software Defined Systems (SDS), 2019
In this paper, we describe a scheme for dynamically provisioning hardware-accelerator resources to virtual network functions (VNF) in an NFV environment. The scheme involves collaboration between various NFV components like service-specific manager (SSM) and element-management-systems (EMSs) for the management of accelerator resources.
Sharma, Gourav Prateek   +3 more
openaire   +2 more sources

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